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4-Amino-3-fluoropyridine

4-Amino-3-fluoropyridine structure

CAS No:
2247-88-3
Formula:
C5H5FN2
Chemical Name:
4-Amino-3-fluoropyridine
Synonyms:
4-氨基-3-氟吡啶;fluoropyridin-4-amine;4-AMINO-3-FLUOROPYRINE;3-Fluoro-4-pyridinamine;3-FLUOROPYRIDIN-4-AMINE;3-FLUORO-4-AMINOPYRIDINE;4-AMINO-3-FLUOROPYRIDINE;4-Amino-3-fluoropyridine97%;4-Amino-3-fluoropyridine,98%;4-Amino-3-fluoropyridine
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

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Description

Yellow to light yellow crystals

4-Amino-3-fluoropyridine Basic Attributes

Molecular Weight：

112.11

Exact Mass：

112.043678

UNII：

Y744OES4EP

DSSTox ID：

DTXSID70355751

HScode：

29333990

Characteristics

PSA：

38.9

XLogP3：

0.3

Appearance：

Yellow to light yellow crystals

Density：

1.3±0.1 g/cm3

Melting Point：

74-77

Boiling Point：

217.1°C at 760 mmHg

Flash Point：

85.1±21.8 °C

Refractive Index：

1.554

Vapor Pressure：

0.135mmHg at 25°C

Safety Information

Hazard category：

6.1

Transport codes：

NONH for all modes of transport

wgk germany：

nwg

hazard class code：

22-36

safety instructions：

Marks：

Xi,Xn

Hazard note：

Irritant

Precautionary statement(s)：

P305 + P351 + P338

Hazard Statements：

H302-H319

GHS Classification：

|Warning|H302 (88.89%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 45 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

4-Amino-3-fluoropyridine Use and Manufacturing

General procedure: A microwave tube was charged with 6'-bromo-8'-chloro-2'H-spiro[cyclohexane-1, 3'-imidazo[1, 5-a]pyridine]-1', 5'-dione 3 (1.00 eq.), amine (1.00 eq.), Cs2CO3 (2.00 eq.), Pd2(dba)3 (0.10 eq.), xantphos (0.10 eq.) and 1, 4-dioxane (4 mL). The reaction mixture was heated under microwave irradiation at 130 C for 30 min, concentrated under reduced pressure, and purified by flash column chromatography (silica gel, DCM ramping to DCM/CH3OH = 9:1) to yield the desired product.

Computed Properties

Molecular Weight:112.10
XLogP3:0.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Exact Mass:112.04367633
Monoisotopic Mass:112.04367633
Topological Polar Surface Area:38.9
Heavy Atom Count:8
Complexity:76.8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Acetic acid

Ammonia

Sulfuric acid

Nitric acid

Hydrogen peroxide

Ferrous sulfate heptahydrate

Recommended Suppliers of 4-Amino-3-fluoropyridine

Hangzhou KieRay Chem Co.,LTD Contact Supplier

CN
5 YRS

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Manufactory Supplier of fine chemicals,pharmaceutical materials

4-Amino-3-fluoropyridine

CAS No.: 2247-88-3

Grade: industrial Grade

Content: 98%

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Hangzhou zhongqi chem co.,Ltd Contact Supplier

CN
2 YRS

Business licensed

Trader Supplier of Fine chemicals,Pharmaceutical Intermediates

4-Amino-3-fluoropyridine (high qualified)

Unit Price: $1-1.2 /KG FOB

CAS No.: 2247-88-3

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