enniatinA
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enniatinA
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CAS No:
2503-13-1
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Formula:
C36H63N3O9
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Chemical Name:
enniatinA
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Synonyms:
enniatinA;LateritinI;N-Methylcyclo(L-Ile-D-Hmb-N-methyl-L-Ile-D-Hmb-N-methyl-L-Ile-D-Hmb-);Cyclo[(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-isoleucyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-isoleucyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-isoleucyl]
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CAS No:
Description
ChEBI: An enniatin obtained from formal cyclocondensation of three N-[(2R)-2-hydroxy-3-methylbutanoyl]-N-methyl-L-isoleucine units.
Safety Information
6.1(a)
2811
3
23/24/25
45
T
|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P311, P312, P321, P322, P330, P361, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 39 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
enniatinA Use and Manufacturing
Enniatins are cyclohexadepsipeptides commonly isolated from fungi that are known to have antibiotic properties and to induce apoptosis in several cancer lines. Many function as ionophores, forming pores in cellular membranes to allow selective ion transport. Enniatin A is one of four major analogs in the enniatin complex . It has been shown to moderately inhibit acyl-CoA:cholesterol acyltranferase activity in rat liver microsomes with an IC50 value of 22 μM. Enniatin A also demonstrates anthelmintic properties against N. brasiliensis, T. spiralis, and H. spumosa.[Cayman Chemical]
Computed Properties
Molecular Weight:681.9
XLogP3:7.6
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:9
Exact Mass:681.45643060
Monoisotopic Mass:681.45643060
Topological Polar Surface Area:140
Heavy Atom Count:48
Complexity:1000
Undefined Atom Stereocenter Count:9
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes