Chloral hydrate
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Chloral hydrate
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CAS No:
302-17-0
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Formula:
C2H3Cl3O2
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Chemical Name:
Chloral hydrate
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Synonyms:
1,1-Ethanediol,2,2,2-trichloro-;Chloral hydrate;2,2,2-Trichloro-1,1-ethanediol;Chloral,monohydrate;Trichloroacetaldehyde hydrate;Trawotox;Bi 3411;Trichloroacetaldehyde monohydrate;Noctec;Nycton;Somnos;Lorinal;Chloraldurat;1,1,1-Trichloro-2,2-dihydroxyethane;Dormal;Phaldrone;Rectules;Hydral;Nycoton;SK Chloral hydrate;Escre;NSC 3210;Fagron;109128-19-0
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CAS No:
Description
colourless crystals with a pentrating odour Chloral is a combustible, oily liquid with a pungent irritating odor.
Characteristics
40.5
0.99
Transparent colorless crystals or white crystalline solid. Aromatic penetrating slightly acrid odor and a slightly bitter caustic taste. Alcoholic solution (1 in 20) does not at once redden moistened blue litmus paper. (NTP, 1992)
2 x 10-6 g/cm3 @ Temp: 20 °C
57 °C
98 °C
16 °C
1.546
H2O: 660 g/100 mL;Solubility in water: very good
0-6°C
15 mm Hg at 25 deg C
5.1 (Air= 1)
Oral-rat LD50: 479 mg/kg; Oral-Mouse LD50: 1100 mg/kg
In case of heat, open flame burning; thermal decomposition to emit toxic chloride fumes
Aromatic, penetrating and slightly acrid odor
Slightly bitter, caustic taste
3.5-4.4 (10% soln in water)
Safety Information
III
6.1(b)
UN 3286 3/PG 2
2
25-36/38-39/23/24/25-23/24/25-11-36/37/38-36-20/21/22
26-45-25-23-36/37-16-27
FM8750000
T,F,Xn
The warehouse is low-temperature, ventilated and dry; prevent fire, high temperature, and store it separately from food materials and oxidants
Stable, but may be air or light sensitive. Incompatible with alcohols, cyanides, iodine, strong bases, carbonates.
P280-P305 + P351 + P338
H302-H312-H319-H332
Chloral hydrate Use and Manufacturing
Trichloroacetaldehyde Hydrate is a useful chemical reagent used as a sedative/hypnotic agent for the short-term treatment of insomnia. First developed in 1832, chloral hydrate is the oldest sleep medication still in use today. This medication is also used to calm you just before surgery or other procedures. It works by affecting certain parts of the brain to cause calmness.Studies have shown that when used in pediatric sedation side effects such as hallucination, excessive sleep and seizures were observed. Drowsiness and trouble waking up in the morning, nausea, vomiting, stomach pain, diarrhea, and headache may occur. Stomach problems can be reduced by taking chloral hydrate with a full glass of water. It is sometimes administered to patients being treated with cyclophosphamide and it is known to inhibit some aldehyde dehydrogenases.Besides, Chloral hydrate is a starting point for the synthesis of other organic compounds. It is the starting material for the production of chloral, which is produced by the distillation of a mixture of chloral hydrate and sulfuric acid, which serves as the desiccant.
Computed Properties
Molecular Weight:165.40
XLogP3:1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Exact Mass:163.919862
Monoisotopic Mass:163.919862
Topological Polar Surface Area:40.5
Heavy Atom Count:7
Complexity:56.4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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