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Argipressine

Argipressine structure

CAS No:
113-79-1
Formula:
C46H65N15O12S2
Chemical Name:
Argipressine
Synonyms:
AVP;argipressin;argipressine;β-Hypophamine;Arg-Vasopressin;BETA-HYPOPHAMINE;[ARG8]-VASOPRESSIN;VASOPRESSIN(ARG8);vasopressintannate;(ARG-8)Vasapressin
Categories:
Active Pharmaceutical Ingredients > Urinary System Drugs

Description

ChEBI: The predominant form of mammalian vasopressin (antidiuretic hormone). It is a nonapeptide containing an arginine at residue 8 and two disulfide-linked cysteines at residues of 1 and 6.Vasopressin tannate (PitressinTannate) is a water-insoluble tannate of vasopressin administeredintramuscularly (1.5–5.0 pressor units daily)for its prolonged duration of action by the slow release ofvasopressin. It is particularly useful for patients who havediabetes insipidus, but it should never be used i

Argipressin is the predominant form of mammalian vasopressin (antidiuretic hormone). It is a nonapeptide containing an arginine at residue 8 and two disulfide-linked cysteines at residues of 1 and 6. It has a role as a cardiovascular drug, a hematologic agent and a mitogen.|The physiologic effect of vasopressin is by means of Vasoconstriction, and Decreased Diuresis.|Argipressin is a synthetic peptide identical to the endogenous nonapeptide hormone with antidiuretic property. Synthesized in the hypothalamus and stored/released from the posterior lobe of the pituitary, argipressin's primary function is regulating extracellular fluid volume. This agent can also act as a vasoconstrictor, increasing blood pressure and systemic vascular resistance.|The predominant form of mammalian antidiuretic hormone. It is a nonapeptide containing an ARGININE at residue 8 and two disulfide-linked cysteines at residues of 1 and 6. Arg-vasopressin is used to treat DIABETES INSIPIDUS or to improve vasomotor tone and BLOOD PRESSURE.

Argipressine Basic Attributes

Molecular Weight：

1084.23

Exact Mass：

1083.437866

EC Number：

204-035-4

UNII：

Y4907O6MFD

DSSTox ID：

DTXSID0048349

NCI Thesaurus Code：

C926

HScode：

2937190000

Characteristics

PSA：

515

XLogP3：

-5.99

Appearance：

White powder

Density：

1.59±0.1 g/cm3(Predicted)

Flash Point：

113℃

Refractive Index：

1.724

Water Solubility：

WATER soluble

Storage Conditions：

2-8°C

Toxicity：

TDLo ivn-pig: 40 ng/kg JPETAB 293,852,2000

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

safety instructions：

Marks：

Stability/Shelf Life：

STABLE @ ROOM TEMP /TANNATE/

Precautionary statement(s)：

P261

Hazard Statements：

H332

GHS Classification：

|Warning|H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]|P261, P271, P304+P312, P304+P340, and P312|Aggregated GHS information provided by 39 companies from 1 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Drugs used to cause constriction of the blood vessels. (See all compounds classified as Vasoconstrictor Agents.)|Agents that reduce the excretion of URINE, most notably the octapeptide VASOPRESSINS. (See all compounds classified as Antidiuretic Agents.)|Agents acting to arrest the flow of blood. Absorbable hemostatics arrest bleeding either by the formation of an artificial clot or by providing a mechanical matrix that facilitates clotting when applied directly to the bleeding surface. These agents function more at the capillary level and are not effective at stemming arterial or venous bleeding under any significant intravascular pressure. (See all compounds classified as Hemostatics.)

MeSH Entry Terms：

Arg Vasopressin

Argipressine Use and Manufacturing

Hormone (antidiuretic).ADH itself is available for injections (Pitressin) but has a half-life of about 15 minutes. Desmopressin (DDAVP) is an analogue without an amino group at the first amino acid and with D-arginine instead of Larginine. This analogue is more stable and has very little pressor activity. Desmopressin can be given subcutaneously or nasally, and the effects last for 12 hours.Because it is stable, desmopressin is preferred for treatments especially if pressor effects are n

Computed Properties

Molecular Weight:1084.2
XLogP3:-4.8
Hydrogen Bond Donor Count:14
Hydrogen Bond Acceptor Count:16
Rotatable Bond Count:19
Exact Mass:1083.43785492
Monoisotopic Mass:1083.43785492
Topological Polar Surface Area:515
Heavy Atom Count:75
Complexity:2070
Defined Atom Stereocenter Count:8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Antidiuretic hormone drug. This product can promote the reabsorption of water by the distal renal tubules and collecting ducts and has an antidiuretic effect.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Vasopressin Tannate Injection
Ingredients	Tannic acid vasopressin.
Specifications	5 ml: 300 units

Registered Holders

Aspen Oss B.V.

Netherlands
Inactive

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