Propoxur

Propoxur is a carbamate insecticide with a fast knockdown and long residual effect used against turf, forestry, and household pests and fleas.

Preparation of o-isopropoxyphenol by methyl isocyanate method 1mol 2-bromopropane is slowly dropped into the refluxing mixture of 1mol catechol, 2mol potassium carbonate, methyl ethyl ketone and phase transfer catalyst. Continue to reflux for a certain period of time, then distill out most of the methyl ethyl ketone, add enough water to dissolve the solid salt, and then extract with benzene. The extract is extracted with dilute sodium hydroxide solution, and the extract is neutralized with dilute hydrochloric acid before reuse. Benzene extraction, calcium chloride drying, most of the benzene was distilled off, and the fractions of 84-86°C/333.3Pa were collected under reduced pressure. Obtain colorless transparent o-isopropoxyphenol, n25D1.5131, yield >60%. For the preparation of methyl isocyanate, see the preparation method of manacarb. The synthesis of carbendazole dissolves 1 mol o-isopropoxyphenol in dioxane. Add 1 mol of acid-binding agent, add 1 mol of solid carbamoyl chloride in portions under stirring, stir at room temperature for 1 h, then pour the mixture into ice water, stir thoroughly, suction after crystallization is complete, wash with cold water, petroleum ether, and dry Afterwards, it can be killed, the yield is 75%, the melting point is 90.5 ~ 91 ℃. It is reported in foreign literature that the killing of Vital is produced by the isocyanate method, which is obtained by reacting o-isopropoxyphenol and isocyanate in dioxane solvent, and adding a few drops of triethylamine as a catalyst. After washing, drying, and recrystallizing, it can be prepared to kill, with a yield of 84%. The chloroformate method first synthesizes isopropoxy chloroformic acid phenol ester, and then amine decomposes to synthesize carbamazone. Both reactions are carried out at low temperature.

Propoxur is a non-systematic carbamate insecticide. Propoxur is used against a wide range of insects such as fleas, mosquitoes, ants, gypsy moths, and other agricultural pests. Propoxur functions by reversibly inactivating the enzyme acetylcholinesterase in insects.

Molecular Weight:209.24
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:209.10519334
Monoisotopic Mass:209.10519334
Topological Polar Surface Area:47.6
Heavy Atom Count:15
Complexity:206
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes