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Gambogic acid

Gambogic acid structure

CAS No:
2752-65-0
Formula:
C38H44O8
Chemical Name:
Gambogic acid
Synonyms:
2-Butenoic acid,2-methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-buten-1-yl)-11-(4-methyl-3-penten-1-yl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-,(2Z)-;1,5-Methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthene-1-crotonic acid,3a,4,5,7-tetrahydro-8-hydroxy-α,3,3,11-tetramethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-,(Z)-;Gambogic acid;2-Butenoic acid,2-methyl-4-[3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-,[1R-[1α,1(Z),3aβ,5α,11β,14aS*]]-;2-Butenoic acid,2-methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-,(2Z)-;(2Z)-2-Methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-buten-1-yl)-11-(4-methyl-3-penten-1-yl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-2-butenoic acid;β-Guttiferin;R-Gambogic acid;(-)-Gambogic acid;UI1907;18833-83-5
Categories:
Biochemical Engineering > Plant Extracts

Description

Gambogic acid is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic acid inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM.

Gambogic acid Basic Attributes

Molecular Weight：

628.75

Exact Mass：

628.75

HScode：

2942000000

Characteristics

PSA：

119

XLogP3：

7.23930

Appearance：

yellow to orange

Density：

1.3±0.1 g/cm3

Melting Point：

78-90 °C

Boiling Point：

808.9°C at 760 mmHg

Flash Point：

251.4±27.8 °C

Refractive Index：

1.627

Water Solubility：

DMSO: ≥10mg/mL

Storage Conditions：

Store at -20°C

Vapor Pressure：

1.21E-27mmHg at 25°C

Toxicity：

Abdominal-rat LD50: 88 mg/kg; intravenous-mouse LD50: 107 mg/kg

Flammability characteristics：

Open flame is flammable; thermal decomposition emits spicy and irritating smoke

Specific rotation：

D20 -685° (methanol)

Safety Information

Packing level：

Ⅲ

Transport codes：

UN 2811 6.1 / PGIII

wgk germany：

hazard class code：

25-36/37/38

safety instructions：

26-45

RTECS Number：

PB9268200

Marks：

Storage features：

The warehouse is ventilated, low temperature and dry; stored and transported separately from food materials

Precautionary statement(s)：

P261-P301 + P310-P305 + P351 + P338

Hazard Statements：

H301-H315-H319-H335

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

highly toxic

Drug Information

MeSH Entry Terms：

gamboge acid

Gambogic acid Use and Manufacturing

antiinflammatory, cytotoxic, inhibits HeLa cells in vitro;

Computed Properties

Molecular Weight:628.7
XLogP3:7.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:8
Exact Mass:628.30361836
Monoisotopic Mass:628.30361836
Topological Polar Surface Area:119
Heavy Atom Count:46
Complexity:1490
Undefined Atom Stereocenter Count:5
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Gambogic acid

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

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Gambogic acid

CAS No.: 2752-65-0

Content: 99.00%

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Guide of Gambogic acid

Description
Basic Attributes
Characteristics
Safety Information
Toxicity
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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Gambogic acid

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