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Benzamil

Benzamil structure

Benzamil 

structure
  • CAS No:

    2898-76-2

  • Formula:

    C13H14ClN7O

  • Chemical Name:

    Benzamil

  • Synonyms:

    2-Pyrazinecarboxamide,3,5-diamino-6-chloro-N-[imino[(phenylmethyl)amino]methyl]-;Pyrazinecarboxamide,3,5-diamino-N-(benzylamidino)-6-chloro-;Pyrazinecarboxamide,3,5-diamino-6-chloro-N-[imino[(phenylmethyl)amino]methyl]-;3,5-Diamino-6-chloro-N-[imino[(phenylmethyl)amino]methyl]-2-pyrazinecarboxamide;Benzamil;Benzylamiloride

Description

Benzamil (Benzylamiloride), an Amiloride analogue, is a Na+/Ca2+ exchanger (NCX) inhibitor (IC50~100 nM). Benzamil also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil inhibits TRPP3-mediated Ca2+-activated currents, with an IC50 of 1.1 μM[1][2][3].


Benzamil is a member of pyrazines and a member of guanidines.

Benzamil Basic Attributes

356.21

319.75

04659UUJ94

DTXSID90183179

2934999090

Characteristics

145.30000

3.59470

solid

1.59±0.1 g/cm3(Predicted)

215-216 °C (decomp)

methanol: 10 mg/mL

2-8°C

Safety Information

6.1(b)

2811

3

36/37/38

26-36

Xi

Drug Information

benzamil

Computed Properties

Molecular Weight:319.75
XLogP3:1.7
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:319.0948358
Monoisotopic Mass:319.0948358
Topological Polar Surface Area:145
Heavy Atom Count:22
Complexity:413
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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