3-Methyl-4-(methylthio)phenol

OtherSolid

OtherSolid

4-(methylsulfanyl)-m-cresol is an aryl sulfide and a member of phenols. It derives from a m-cresol.

The preparation of p-methylthiomet-cresol mainly includes dimethyl disulfide method and dimethyl sulfoxide method. (1) The dimethyl disulfide method is derived from the reaction of m-cresol and dimethyl disulfide. Add m-cresol and dimethyl disulfide to the reaction kettle, stir, cool to 0°C, add sulfuric acid dropwise, add it in about 1h, keep the temperature below 5°C and react for 3h, then stand for stratification. The organic layer is neutralized with 10% sodium carbonate solution, then washed with water to pH=7-8, and then distilled under reduced pressure to recover unreacted m-cresol and dimethyl disulfide. The remaining material is p-methylthio Cresol. (2) The dimethyl sulfoxide method uses m-cresol and dimethyl sulfoxide as raw materials. This method is divided into hydrogen chloride method, phosgene method and benzoyl chloride method. The hydrogen chloride method is mainly used in China. Mix and stir dimethyl sulfoxide and m-cresol, and pass hydrogen chloride gas to saturation at a certain temperature until a large amount of white smoke escapes. Add a certain amount of m-cresol to the white paste-like sulfonium salt produced by the reaction as a decomposition solvent (usually xylene), stir at room temperature for a few minutes to drive out the hydrogen chloride dissolved in the sulfonium salt, and then add a certain amount of m-cresol to 120～130 Decompose under reflux at ℃ for 1.5～2h, and distill out m-cresol under reduced pressure to obtain the product.

Used as an intermediate in organic synthesis

Intermediates

Agricultural products

25,000 - 100,000 lb

Molecular Weight:154.23
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:154.04523611
Monoisotopic Mass:154.04523611
Topological Polar Surface Area:45.5
Heavy Atom Count:10
Complexity:105
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes