 Home > Encyclopedia > Tridihexethyl

Tridihexethyl

Tridihexethyl structure

CAS No:
60-49-1
Formula:
C21H36NO
Chemical Name:
Tridihexethyl
Synonyms:
Benzenepropanaminium,γ-cyclohexyl-N,N,N-triethyl-γ-hydroxy-;Ammonium,(3-cyclohexyl-3-hydroxy-3-phenylpropyl)triethyl-;γ-Cyclohexyl-N,N,N-triethyl-γ-hydroxybenzenepropanaminium;Tridihexethyl
Categories:
Organic Chemistry > Amides

Description

Solid

Tridihexethyl is a tertiary alcohol and a quaternary ammonium ion. It has a role as an anti-ulcer drug, a muscarinic antagonist and an antispasmodic drug.|Tridihexethyl is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. Tridihexethyl is an antimuscarinic, anticholinergic drug. Tridihexethyl is no longer available in the US market.

Tridihexethyl Basic Attributes

Molecular Weight：

318.525

Exact Mass：

318.28

DSSTox ID：

DTXSID0048553

ATC Code：

A - Alimentary tract and metabolism

Characteristics

PSA：

20.2

XLogP3：

1.17

Appearance：

Solid

Melting Point：

181.5 °C

Water Solubility：

1.68e-05 g/L

Drug Information

Drug Indication：

Used as an adjunct in the treatment of peptic ulcer disease and in Acquired nystagmus

Pharmacology：

Tridihexethyl is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. Tridihexethyl is an antimuscarinic, anticholinergic drug.

Mechanism of Action：

Tridihexethyl binds the muscarinic acetylcholine receptor. It may block all three types of muscarinic receptors including M-1 receptors in the CNS and ganglia, M-2 receptors in the heart (vagus) and M-3 receptors at the parasympathetic NEJ system. The muscarinic acetylcholine receptors mediate various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Tridihexethyl inhibits vagally mediated reflexes by antagonizing the action of acetylcholine. This in turn reduces the secretion of gastric acids in the stomach.

MeSH Entry Terms：

(3-cyclohexyl-3-hydroxy-3-phenylpropyl)triethylammonium iodide

Computed Properties

Molecular Weight:318.5
XLogP3:4.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:8
Exact Mass:318.279689772
Monoisotopic Mass:318.279689772
Topological Polar Surface Area:20.2
Heavy Atom Count:23
Formal Charge:1
Complexity:319
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes