4-Methyl-2-pentanol

102.17

102.17

1098268

210-790-0

0665

9384

2053

DTXSID2026781

COLORLESS LIQ|Colorless liquid.

29051900

20.23000

1.57

Clear colorless Liquid

0.8075 g/cm³ @ Temp: 20 °C

-90 °C

133 °C @ Press: 760 Torr

107 °F

1.412

H2O: 2 g/100 mL

Flammables area

3.7 mm Hg ( 20 °C)

3.5 (vs air)

Oral-rat LD50: 2590 mg/kg; Abdominal cavity-mouse LD50: 812 mg/kg

Flammable; spicy and irritating smoke is released from the fire

1-5.5%(V)

Mild odor.

4.45e-05 atm-m3/mole

WT/GAL 6.72 LB @ 20 °C; SETS TO A GLASS BELOW -90 °C|CONVERSION FACTORS: 1 PPM= 4.17 MG/CU M; 1 MG/L= 239.3 PPM

Flammable. Soluble in water.

Alcohols and Polyols

METHYL ISOBUTYL CARBINOL is an alcohol. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides. This compound is incompatible with strong oxidizers (NIOSH, 2016).

4-Methyl-2-pentanol|B: Compounds that form peroxides on concentration (distillation/evaporation)|1 samples had 20-30 ppm peroxide; age >1 yrs|Kelly

Class II Combustible Liquid: Fl.P. at or above 100°F and below 140°F.

The vapour is heavier than air and may travel along the ground; distant ignition possible.

III

3

UN 2282 3/PG 3

1

10-37-36/37/38

24/25-26

SA7350000

Xi

Treasury is ventilated, low temperature and dry; stored and transported separately from oxidant

Steam and air can be explosive when mixed

Stable. Flammable. Incompatible with oxidizing agents, acids, acid chlorides.

P210-P305 + P351 + P338-P370 + P378

H226-H319-H335

Strong oxidizers.

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. (ERG, 2016)|Flammable. Above 41 °C explosive vapour/air mixtures may be formed.|Flammable - 2nd degree

|Warning|H226: Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P261, P271, P280, P303+P361+P353, P304+P340, P312, P370+P378, P403+P233, P403+P235, P405, and P501|H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P303+P361+P353, P304+P340, P305+P351+P338, P312, P337+P313, P370+P378, P403+P233, P403+P235, P405, and P501|Aggregated GHS information provided by 1341 companies from 30 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P302+P352, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P370+P378, P403+P233, P403+P235, P405, and P501|P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P303+P361+P353, P304+P340, P305+P351+P338, P312, P332+P313, P337+P313, P370+P378, P403+P233, P403+P235, P405, and P501

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]: As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet). FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material. LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2016)

Skin: Wear appropriate personal protective clothing to prevent skin contact. Eyes: Wear appropriate eye protection to prevent eye contact. Wash skin: The worker should immediately wash the skin when it becomes contaminated. Remove: Work clothing that becomes wet or significantly contaminated should be removed and replaced. Change: No recommendation is made specifying the need for the worker to change clothing after the work shift. (NIOSH, 2016)|Wear appropriate personal protective clothing to prevent skin contact.|Wear appropriate eye protection to prevent eye contact.|Recommendations for respirator selection. Max concn for use: 250 ppm. Respirator Class(es): Any supplied-air respirator. May require eye protection.|Recommendations for respirator selection. Max concn for use: 400 ppm. Respirator Class(es): Any supplied-air respirator operated in a continuous flow mode. May require eye protection. Any self-contained breathing apparatus with a full facepiece. Any supplied-air respirator with a full facepiece.|For more Personal Protective Equipment (PPE) (Complete) data for 4-METHYL-2-PENTANOL (6 total), please visit the HSDB record page.|(See protection codes)

MODERATE FIRE RISK.

IN AIR, 1-5.5%.|Explosive limits , vol% in air: 1.0-5.5

ALCOHOL FOAM.

The worker should immediately wash the skin when it becomes contaminated.|Work clothing that becomes wet or significantly contaminated should be removed and replaced.|SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.|/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Health: May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.|/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.|/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection.|For more DOT Emergency Guidelines (Complete) data for 4-METHYL-2-PENTANOL (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Contact may irritate or burn skin and eyes.|... EYE IRRITATION WAS PRODUCED @ 50 PPM.

Permissible Exposure Limit: Table Z-1 8-hr Time-Weighted Avg: 25 ppm (100 mg/cu m). Skin Designation.|Vacated 1989 OSHA PEL TWA 25 ppm (100 mg/cu m); STEL 40 ppm (165 mg/cu m), skin designation, is still enforced in some states.

Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 25 ppm (100 mg/cu m).|Recommended Exposure Limit: 15 Min Short-Term Exposure Limit: 40 ppm (165 mg/cu m), skin.

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT wash away into sewer.

Fireproof if in building. Separated from strong oxidants. Cool.

A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20 °C.

The substance is irritating to the eyes, skin and respiratory tract. Exposure could cause lowering of consciousness.

The substance defats the skin, which may cause dryness or cracking.

NO open flames, NO sparks and NO smoking. Above 41 °C use a closed system, ventilation and explosion-proof electrical equipment.

PREVENT GENERATION OF MISTS!

Use ventilation, local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear safety goggles.

This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Methyl isobutyl carbinol is produced, as an intermediate or final product, by process units covered under this subpart.

| 2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury.| 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air.| 0 - Materials that in themselves are normally stable, even under fire conditions.

4-Methyl-2-pentanol was detected at a concn of 136 ppb in a sample of influent water from an unspecified municipal wastewater treatment plant(1). It was not indicated whether the compound was detected in final effluent from the plant(1). It was detected at a concn of 45 ppb in effluent samples taken from the Los Angeles County wastewater treatment plant discharge, Palos Verdes, CA between Nov 1980 and Aug 1981(2). A concn of 140 ppm was found in samples of leachate or samples of groundwater plume taken at an unspecified industrial landfill at an unspecified time(3). 4-Methyl-2-pentanol was qualitatively detected in 4 of 16 samples of concentrate derived from large volume (>400 gallons) samples of advanced treatment concentrate from 4 of 6 cities (Lake Tahoe, CA, Oct 1974; Pomona, CA, 1975; Orange County, CA, Feb 1976; Blue Plains, Washington, DC, May 1975)(4).

4-Methyl-2-pentanol was not detected (detection limit 0.5 ug/kg, dry weight basis) in two samples of marine sediment taken 6 km from the Los Angeles County wastewater treatment plant discharge, Palos Verdes, CA between Nov 1980 and Aug 1981(1).

4-Methyl-2-pentanol was qualitatively detected in ambient air samples taken Nov 20, 1979 at the BFI Landfill in New Jersey(1). It was detected in ambient air during an air pollution peak at concn ranging from 0.9 to 7.0 ppb; date and location not specified(2).

moderately toxic

LD50 Rat oral 2.6 g/kg|LD50 Rabbit /dermal/ 3.56 ml/kg/24 hr

4-Methyl-2-pentanol was qualitatively detected in the mixture of volatiles from mountain Beaufort cheese(1) which indicates that the compound may be formed naturally(SRC).

4-Methyl-2-pentanol may be released to the environment as a result of its manufacture and use as a solvent for dyestuffs, oils, gums, resins, waxes, nitrocellulose and ethylcellulose; its use in organic synthesis, froth flotation; and its use in brake fluids(1).

TERRESTRIAL FATE: If 4-methyl-2-pentanol is released to soil, it will be expected to exhibit high to very high mobility in soil(1,SRC) based upon estimated Koc of 143 and 21 estimated from log Kow(2) and water solubility(3), respectively, using a recommended regression equations(4,SRC). It may, therefore, leach through soil(SRC). It will not hydrolyze in moist soil(4), but it may be subject to volatilization from near surface soil based upon estimated rates for its volatilization from water(4-6). It may be subject to biodegradation in soil based upon the rapid biodegradation observed in laboratory aqueous screening tests using sewage and activated sludge inoculum(7,8).|AQUATIC FATE: If 4-methyl-2-pentanol is released to water, it will not be expected to adsorb to sediment and suspended particulate matter or to bioconcentrate in aquatic organisms based upon estimated Koc and BCF, respectively, estimated(2,SRC) from the measured log Kow (1) and water solubility(3). It will not be expected to hydrolyze(2) or directly photolyze(4,SRC). It may be subject to biodegradation in natural waters based upon the rapid biodegradation observed in laboratory aqueous screening tests using sewage and activated sludge inoculum(5,6). It will be subject to volatilization from surface waters based upon half-lives of 23 hr for volatilization from a model river one meter deep flowing 1 m/sec with a wind velocity of 3 m/sec(2,SRC) and 10.6 days for volatilization from a model pond(7,SRC), respectively, estimated using a measured Henry's Law constant(8).|ATMOSPHERIC FATE: If 4-methyl-2-pentanol is released to the atmosphere, it can be expected to exist mainly in the vapor-phase in the ambient atmosphere(1,SRC) based upon an experimental vapor pressure of 5.3 mm Hg at 25 °C(2,SRC). The measured rate constant for vapor-phase reaction with photochemically produced hydroxyl radicals of 7.1X10-12 cu cm/molecule-sec at 25 °C(3) corresponds to an atmospheric half-life of 2.3 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(SRC). 4-Methyl-2-pentanol has been rated a moderately reactive (Class III) compound(4) with respect to ozone formation as observed in smog chamber tests(5). 4-Methyl-2-pentanol will not be expected to directly photolyze in the atmosphere(6,SRC).

The rate constant for the vapor-phase reaction of 4-methyl-2-pentanol with photochemically produced hydroxyl radicals has been measured to be 7.1X10-12 cu cm/molecule-sec at 25 °C(1) which corresponds to an atmospheric half-life of 2.3 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(SRC). 4-Methyl-2-pentanol was rated as a moderately reactive (Class III) compound(2) with respect to ozone formation as observed in smog chamber tests where the initial 4-methyl-2-pentanol concn was 1.5 ppm (by volume) and the initial NOx concn was 0.6 ppm(3). Because alcohols do not absorb light at wavelengths above 290 nm(4), 4-methyl-2-pentanol will not be expected to directly photolyze in the environment(SRC). Hydrolysis is not expected to be a major pathway under normal environmental conditions because of the lack of hydrolysis functional groups (pH 5-9)(5).

Based upon an experimental log Kow of 1.43(1), a BCF of 7.2 has been estimated using a recommended regression equation(2). Based upon an experimental water solubility of 1.64X10+4 mg/kg(3), a BCF of 2.6 has been estimated using a recommended regression equation(2). Based upon these estimated BCF, 4-methyl-2-pentanol will not be expected to bioconcentrate in aquatic organisms(SRC).

Based upon an experimental log Kow of 1.43(1), a Koc of 143 has been estimated using a recommended regression equation(2). Based upon an experimental water solubility of 1.64X10+4 mg/kg(3), a Koc of 21 has been estimated using a recommended regression equation(2). Based upon these estimated Koc, 4-methyl-2-pentanol will be expected to exhibit high to very high mobility in soil(4). 4-Methyl-2-pentanol, therefore, may leach through soil to groundwater if it does not volatilize or biodegrade first(SRC).

The half-life for volatilization of 4-methyl-2-pentanol from a river one meter deep flowing 1 m/sec with a wind velocity of 3 m/sec is estimated to be 23 hr at 25 °C(1,SRC) based upon an experimental Henry's Law constant of 4.45X10-5 atm-cu m/mole(2). The volatilization half-life from a model pond, which considers the effect of adsorption, has been estimated to be 10.6 days(3,SRC).

DRINKING WATER: 4-Methyl-2-pentanol was qualitatively detected in 4 of 15 samples drinking water concentrate derived from large volume (>400 gallons) samples from 4 of 7 cities (Poplarville, MS, March 1979; Cincinnati, OH, Oct 1978; Philadelphia, PA, Feb 1976; Ottumwa, IA, Sept 1976)(1).

4-Methyl-2-pentanol was qualitatively detected in the mixture of volatiles from mountain Beaufort cheese(1).

General population exposure to 4-methyl-2-pentanol occurs mainly through the oral ingestion of contaminated drinking water(1) and foods, such as certain cheeses(2), and through the inhalation of contaminated ambient air(3). Minor exposure may occur through dermal contact with contaminated water(SRC). Occupational exposure may occur through inhalation of contaminated air and dermal contact with solutions containing the compound(SRC).|NIOSH (NOES Survey 1981-1983) has statistically estmated that 25,135 workers are potentially exposed to 4-methyl-2-pentanol in the USA(1).

... UNDERGOES IN RABBIT SOME GLUCURONIC ACID CONJUGATION. AVG AMT GLUCURONIDE EXCRETED FOLLOWING DOSE ADMIN BY STOMACH TUBE WAS 33.7% OF DOSE. URINE CONTAINED ALSO A SMALL AMT METHYL KETONE (PRESUMABLY ISOBUTYL METHYL KETONE) & AFTER EXTRACTION WITH 1:4 ETHANOL ETHER A GLUCURONIDE (TRIACETYL METHYL ESTER) GUM.

Vapor irritates eyes and nose; may cause anesthesia. Prolonged contact with liquid causes irritation and cracking of skin; also irritates eyes. (USCG, 1999)

Eye: If this chemical contacts the eyes, immediately wash the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately. Contact lenses should not be worn when working with this chemical. Skin: If this chemical contacts the skin, flush the contaminated skin with water promptly. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water promptly. If irritation persists after washing, get medical attention. Breathing: If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform mouth-to-mouth resuscitation. Keep the affected person warm and at rest. Get medical attention as soon as possible. Swallow: If this chemical has been swallowed, get medical attention immediately. (NIOSH, 2016)|(See procedures)

Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

THE LIQ MAY BE VERY SLIGHTLY IRRITATING TO SKIN & IS SLIGHTLY TOXIC WHEN INGESTED.|... EYE IRRITATION WAS PRODUCED @ 50 PPM, ALTHOUGH ODOR WAS NOT OBJECTIONABLE @ THIS LEVEL.

4-methyl-2-pentanol

The substance can be absorbed into the body by inhalation of its vapour and through the skin.|inhalation, skin absorption, ingestion, skin and/or eye contact

irritation eyes, skin; headache, drowsiness; dermatitis; In Animals: narcosis

Cough. Sore throat. Unconsciousness.

Dry skin. Redness. Pain.

Redness. Pain.

Eyes, skin, central nervous system

GRADE: TECHNICAL

All other basic organic chemical manufacturing|2-Pentanol, 4-methyl-: ACTIVE

NIOSH Method 1402. Analyte: 4-methyl-2-pentanol. Matrix: Air. Procedure: Gas Chromatography, Flame Ionization Detection. For Methyl isobutyl carbinol this method has an estimated detection limit of 0.01 mg for a 10 liter sample. The precision/RSD is 0.080 and the recovery is 101.8%. Applicability: The working range is 15 to 150 mg/cu m for a 10 liter air sample. This method may be used to determine two or more analytes simultaneously by varying GC conditions. Interferences: High humidity reduces sampling capacity. Less volatile compounds may displace more volatile compounds on the charcoal.

Food additives -> Flavoring Agents|Fire Hazards -> Flammable - 2nd degree

Flavoring Agents