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Naloxone

Naloxone structure

CAS No:
465-65-6
Formula:
C19H21NO4
Chemical Name:
Naloxone
Synonyms:
Morphinan-6-one,4,5-epoxy-3,14-dihydroxy-17-(2-propen-1-yl)-,(5α)-;Morphinan-6-one,17-allyl-4,5α-epoxy-3,14-dihydroxy-;Morphinan-6-one,4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-,(5α)-;Normorphinone,N-allyl-7,8-dihydro-14-hydroxy-;(5α)-4,5-Epoxy-3,14-dihydroxy-17-(2-propen-1-yl)morphinan-6-one;12-Allyl-7,7a,8,9-tetrahydro-3,7a-dihydroxy-4aH-8,9c-iminoethanophenanthro[4,5-bcd]furan-5(6H)-one;Naloxone;l-Naloxone;(-)-Naloxone;NSC 70413;5592-87-0
Categories:
Active Pharmaceutical Ingredients > Specialty Drugs

Description

ChEBI: A synthetic morphinane alkaloid that is morphinone in which the enone double bond has been reduced to a single bond, the hydrogen at position 14 has been replaced by a hydroxy group, and the methyl group attached to the nitrogen has been replaced by an all l group. A specific opioid antagonist, it is used (commonly as its hydrochloride salt) to reverse the effects of opioids, both following their use of opioids during surgery and in cases of known or suspected opioid overdose.

4a,9-dihydroxy-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one is a member of phenanthrenes.

Naloxone Basic Attributes

Molecular Weight：

327.37

Exact Mass：

327.37

EC Number：

207-365-7

HScode：

2939190000

Characteristics

PSA：

XLogP3：

0.6

Appearance：

Solid

Density：

1.43 g/cm3

Melting Point：

184 °C

Boiling Point：

532.8ºC at 760 mmHg

Flash Point：

9℃

Water Solubility：

H2O: soluble

Storage Conditions：

2-8°C

Vapor Pressure：

4.25X10-11 mm Hg at 25 deg C (est)

Specific rotation：

D20 -194.5° (c = 0.93 in CHCl3)

Safety Information

Transport codes：

UN1230 - class 3 - PG 2 - Methanol, solution

wgk germany：

hazard class code：

11-23/24/25-39/23/24/25

safety instructions：

7-16-36/37-45

Marks：

F,T

Stability/Shelf Life：

Not particularly hygroscopic; can oxidize; relatively stable in heat hydrochloride.

Precautionary statement(s)：

P210-P260-P280-P301 + P310-P311

Hazard Statements：

H225-H301 + H311 + H331-H370

Naloxone Use and Manufacturing

antineoplastic

Computed Properties

Molecular Weight:327.4
XLogP3:2.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:327.14705815
Monoisotopic Mass:327.14705815
Topological Polar Surface Area:70
Heavy Atom Count:24
Complexity:594
Undefined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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CAS No.: 465-65-6

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