Methylthiouracil

142.18

142.18

115648

200-252-3

QW24888U5F

757116|193526|9378

3077

TSCA listed

DTXSID2020890

Clear colorless to yellow

H - Systemic hormonal preparations, excl. sex hormones and insulins

29335995

73.2

-0.2

Clear colorless to yellow Liquid

1.291 (estimate)

~330 °C (dec.)(lit.)

342.3ºC at 760 mmHg

160.8ºC

1.6430 (estimate)

INSOLUBLE

Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ) that bears appropriate label. An inventory should be kept, showing quantity of carcinogen & date it was acquired Facilities for dispensing should be contiguous to storage area.

MLD in rabbits (mg/kg): 2486 orally (Simon)

ODORLESS

BITTER

SATURATED AQ SOLN IS NEUTRAL OR SLIGHTLY ACID TO LITMUS.

pKa 8.2 (Uncertain)

123.7 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

SUBLIMES READILY.|DECOMP @ 326-331 °C.

Insoluble in water.

Amides and Imides

Methylthiouracil reacts with strong oxidizing agents. Forms complexes with metals and is oxidized by iodine and other sulfhydryl oxidizing agents .

Keep in dark place,Sealed in dry,Room Temperature

9

UN 3077 9 / PGIII

3

Xn,Xi

36/37-45

YR0875000

Xn,Xi

Irritant/Possible Carcinogen

Stability Incompatible with strong oxidizing agents, iodine, metals.

P281

22-40

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U164, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.|A potential candidate for rotary kiln incineration at a temperature range of 820 to 1,600 °C and residence times of seconds for liquids and gases, and hours for solids. A potential candidate for fluidized bed incineration at a temperature range of 450 to 980 °C and residence times of seconds for liquids and gases, and longer for solids.|PRECAUTIONS FOR "CARCINOGENS": There is no universal method of disposal that has been proved satisfactory for all carcinogenic compounds & specific methods of chem destruction ... published have not been tested on all kinds of carcinogen-containing waste. ... summary of avail methods & recommendations ... /given/ must be treated as guide only. /Chemical Carcinogens/|PRECAUTIONS FOR "CARCINOGENS": ... Incineration may be only feasible method for disposal of contaminated laboratory waste from biological expt. However, not all incinerators are suitable for this purpose. The most efficient type ... is probably the gas-fired type, in which a first-stage combustion with a less than stoichiometric air:fuel ratio is followed by a second stage with excess air. Some ... are designed to accept ... aqueous & organic-solvent solutions, otherwise it is necessary ... to absorb soln onto suitable combustible material, such as sawdust. Alternatively, chem destruction may be used, esp when small quantities ... are to be destroyed in laboratory. /Chemical Carcinogens/|For more Disposal Methods (Complete) data for METHYLTHIOURACIL (7 total), please visit the HSDB record page.

UN 3077 9 / PGIII

Flash point data for Methylthiouracil are not available. Methylthiouracil is probably combustible.

|Warning|H302 (94.74%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P264, P270, P281, P301+P312, P308+P313, P330, P405, and P501|Aggregated GHS information provided by 58 companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|Danger|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P260, P264, P270, P281, P301+P312, P308+P313, P314, P330, P405, and P501

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, dampen the solid spill material with 5% ammonium hydroxide, then transfer the dampened material to a suitable container. Use absorbent paper dampened with 5% ammonium hydroxide to pick up any remaining material. Your contaminated clothing and the absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with 5% ammonium hydroxide followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should protect this material from exposure to light, and store it in a refrigerator. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). (NTP, 1992)|PRECAUTIONS FOR "CARCINOGENS": ... Dispensers of liq detergent /should be available./ ... Safety pipettes should be used for all pipetting. ... In animal laboratory, personnel should ... wear protective suits (preferably disposable, one-piece & close-fitting at ankles & wrists), gloves, hair covering & overshoes. ... In chemical laboratory, gloves & gowns should always be worn ... however, gloves should not be assumed to provide full protection. Carefully fitted masks or respirators may be necessary when working with particulates or gases, & disposable plastic aprons might provide addnl protection. ... gowns ... /should be/ of distinctive color, this is a reminder that they are not to be worn outside the laboratory. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": Smoking, drinking, eating, storage of food or of food & beverage containers or utensils, & the application of cosmetics should be prohibited in any laboratory. All personnel should remove gloves, if worn, after completion of procedures in which carcinogens have been used. They should ... wash ... hands, preferably using dispensers of liq detergent, & rinse ... thoroughly. Consideration should be given to appropriate methods for cleaning the skin, depending on nature of the contaminant. No standard procedure can be recommended, but the use of organic solvents should be avoided. Safety pipettes should be used for all pipetting. /Chemical Carcinogens/|PRECAUTIONS FOR "CARCINOGENS": In animal laboratory, personnel should remove their outdoor clothes & wear protective suits (preferably disposable, one-piece & close-fitting at ankles & wrists), gloves, hair covering & overshoes. ... clothing should be changed daily but ... discarded immediately if obvious contamination occurs ... /also,/ workers should shower immediately. In chemical laboratory, gloves & gowns should always be worn ... however, gloves should not be assumed to provide full protection. Carefully fitted masks or respirators may be necessary when working with particulates or gases, & disposable plastic aprons might provide addnl protection. If gowns are of distinctive color, this is a reminder that they should not be worn outside of lab. /Chemical Carcinogens/|PRECAUTIONS FOR "CARCINOGENS": ... Operations connected with synth & purification ... should be carried out under well-ventilated hood. Analytical procedures ... should be carried out with care & vapors evolved during ... procedures should be removed. ... Expert advice should be obtained before existing fume cupboards are used ... & when new fume cupboards are installed. It is desirable that there be means for decreasing the rate of air extraction, so that carcinogenic powders can be handled without ... powder being blown around the hood. Glove boxes should be kept under negative air pressure. Air changes should be adequate, so that concn of vapors of volatile carcinogens will not occur. /Chemical Carcinogens/|PRECAUTIONS FOR "CARCINOGENS": Vertical laminar-flow biological safety cabinets may be used for containment of in vitro procedures ... provided that the exhaust air flow is sufficient to provide an inward air flow at the face opening of the cabinet, & contaminated air plenums that are under positive pressure are leak-tight. Horizontal laminar-flow hoods or safety cabinets, where filtered air is blown across the working area towards the operator, should never be used ... Each cabinet or fume cupboard to be used ... should be tested before work is begun (eg, with fume bomb) & label fixed to it, giving date of test & avg air-flow measured. This test should be repeated periodically & after any structural changes. /Chemical Carcinogens/|For more Preventive Measures (Complete) data for METHYLTHIOURACIL (9 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|PRECAUTIONS FOR "CARCINOGENS": Procurement ... of unduly large amt ... should be avoided. To avoid spilling, carcinogens should be transported in securely sealed glass bottles or ampoules, which should themselves be placed inside strong screw-cap or snap-top container that will not open when dropped & will resist attack from the carcinogen. Both bottle & the outside container should be appropriately labelled. ... National post offices, railway companies, road haulage companies & airlines have regulations governing transport of hazardous materials. These authorities should be consulted before ... material is shipped. /Chemical Carcinogens/|PRECAUTIONS FOR "CARCINOGENS": When no regulations exist, the following procedure must be adopted. The carcinogen should be enclosed in a securely sealed, watertight container (primary container), which should be enclosed in a second, unbreakable, leakproof container that will withstand chem attack from the carcinogen (secondary container). The space between primary & secondary container should be filled with absorbent material, which would withstand chem attack from the carcinogen & is sufficient to absorb the entire contents of the primary container in the event of breakage or leakage. Each secondary container should then be enclosed in a strong outer box. The space between the secondary container & the outer box should be filled with an appropriate quantity of shock-absorbent material. Sender should use fastest & most secure form of transport & notify recipient of its departure. If parcel is not received when expected, carrier should be informed so that immediate effort can be made to find it. Traffic schedules should be consulted to avoid ... arrival on weekend or holiday ... /Chemical Carcinogens/

U164; A toxic waste when a discarded commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or manufacturing chemical intermediate.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 10 lb or 4.54 kg. The toll free number of the NRC is (800) 424-8802; In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

As stipulated in 40 CFR 261.33, when methylthiouracil, as a commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate, becomes a waste, it must be managed according to Federal and/or State hazardous waste regulations. Also defined as a hazardous waste is any residue, contaminated soil, water, or other debris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of this waste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5).

THERE EXISTS AN INVERSE RELATIONSHIP BETWEEN IODINE CONTENT OF DIET & MTU THYROID TUMORIGENICITY.|METHYLTHIOURACIL ADMIN PROMOTED INDUCTION OF CERVICO-VAGINAL SARCOMAS & EPITHELIAL TUMORS BY LOCAL APPLICATION OF 9,10-DIMETHYL-1,2-BENZANTHRACENE.|METHYLTHIOURACIL ADMIN SIMULTANEOUSLY WITH CARBON TETRACHLORIDE PREVENTED CARBON TETRACHLORIDE-INDUCED CHRONIC HEPATOTOXICITY IN RATS.|THEOPHYLLINE POTENTIATES EFFECT OF THYROID STIMULATING HORMONE AT LEVEL OF THYROID ADENYL CYCLASE SYSTEM. GOITROGENIC EFFECT OF 0.05% METHYLTHIOURACIL WAS INCR BY SIMULTANEOUS ADMINISTRATION OF THEOPHYLLINE.

There are no known natural sources of methylthiouracil(1).

Release of methylthiouracil to the environment may occur as a result of its production and use as a drug that has been used in the past to treat human hyperthyroidism(1,2). As of 1970, the compound was more broadly used outside the U.S(2). No evidence was found that indicates that methylthiouracil has ever been produced commercially in the U.S.(2,SRC).

TERRESTRIAL FATE: If methylthiouracil is released to soil, it will be expected to be highly mobile in soil(1,SRC) based upon an estimated Koc of 138 which was calculated(2,SRC) from a water solubility of 533.2 mg/l at 25 °C(3) using a recommended regression equation(2,SRC). It may, therefore, leach to groundwater(1,SRC). It is not known whether the compound will photooxidize or biodegrade in soil or volatilize from moist near-surface soil(SRC). But it may slowly biodegrade in natural waters and soil based upon the slow biodegradation of the structurally similar 2-thiouracil by activated sludge from municipal treatment plants(4). Methylthiouracil should not be susceptible to hydrolysis in water based upon a measured neutral hydrolysis rate constant of 9.7X10-6 hr-1 at 25 °C which corresponds to a half-life of 8.8 years(5).|AQUATIC FATE: If it is released to water, methylthiouracil may be susceptible to direct photolysis in surface water based upon its absorption of light at wavelengths greater than 290 nm in methanol solution(1). It should not bioconcentrate in aquatic organisms based upon a BCF of 18 which can be calculated(3,SRC) for methylthiouracil from a water solubility of 533.2 mg/l at 25 °C(2) using a recommended regression equation(3). It should not adsorb to sediment or suspended particulate matter based upon a Koc of 138 which can be calculated(3,SRC) for methylthiouracil from a water solubility of 533.2 mg/l at 25 °C(2) using a recommended regression equation(3). It is not known whether the compound will photooxidize or biodegrade in water(SRC). But it may slowly biodegrade in natural waters and soil based upon the slow biodegradation of the structurally similar 2-thiouracil by activated sludge from municipal treatment plants(4,SRC). Methylthiouracil should not be susceptible to hydrolysis in water based upon a measured neutral hydrolysis rate constant of 9.7X10-6 hr-1 at 25 °C which corresponds to a half-life of 8.8 years(5).|ATMOSPHERIC FATE: Methylthiouracil may be susceptible to direct photolysis in the atmosphere based upon its absorption of light at wavelengths greater than 290 nm in methanol solution(1). Methylthiouracil will be expected to be susceptible to photooxidation in the atmosphere based upon an estimated rate constants for the vapor phase reactions of two of its possible tautomeric forms with photochemically produced hydroxyl radicals and ozone(2,3,SRC). The overall half-lives for the vapor phase reaction of these possible forms of the compound with photochemically produced hydroxyl radicals and ozone have been estimated to range between 2.1 and 3.8 hr at atmospheric concentrations of 5X10+5 hydroxyl radicals per cu cm and 7X10+11 ozone molecules per cu cm(2,3,SRC).

Methylthiouracil may exist in one or more of several tautomeric forms depending on the pH based upon the behavior of uracil(1,2,SRC). These forms include the oxo-thiourea form (2,3-dihydro-6-methyl-2-thioxo-4(1H)-pyrimidinone) and the hydroxy-sulfhydryl- pyrimidine form (2-mercapto-4-hydroxy-6-methylpyrimidine)(1,2,SRC). The presence or absence of any of these forms may affect the reactivity of the compound in the environment(SRC). Methylthiouracil may be susceptible to direct photolysis in water and in the atmosphere based upon the absorption of light at wavelengths greater than 290 nm by methylthiouracil in methanol solution(3).|Methylthiouracil will be expected to be susceptible to photooxidation in the atmosphere based upon estimated rate constants for the vapor phase reactions of two of its possible tautomeric forms with photochemically produced hydroxyl radicals and ozone(1,2,SRC). The rate constant for the vapor phase reaction of the oxo-thiourea form of the compound with photochemically produced hydroxyl radicals has been estimated to be 100X10-12 cu cm/molecule-sec at 25 °C which corresponds to an atmospheric half-life of 3.8 hr at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1,SRC). The rate constants for the vapor phase reactions of the hydroxy-sulfhydryl-pyrimidine form of the compound with photochemically produced hydroxyl radicals and ozone have been estimated to be 168X10-12 cu cm/molecule-sec and 1.14X10-17 cu cm/molecule-sec at 25 °C, respectively, which correspond to an overall atmospheric half-life of 2.1 hr at atmospheric concentrations of 5X10+5 hydroxyl radicals per cu cm and 7X10+11 ozone molecules per cu cm(1,2,SRC).|Methylthiouracil should not be susceptible to hydrolysis in water or moist soil based upon a measured neutral hydrolysis rate constant of 9.7X10-6 hr-1 at 25 °C which corresponds to a half-life of 8.8 years(1).

Based upon a water solubility of 533.2 mg/l at 25 °C(1), a BCF of 18 can be calculated for methylthiouracil using a recommended regression equation(2,SRC). Based upon this estimated BCF, methylthiouracil will not be expected to bioconcentrate in aquatic organisms(SRC).

138.04 L/kg|Based upon a water solubility of 533.2 mg/l at 25 °C(1), a Koc of 138 can be calculated for methylthiouracil using a recommended regression equation(2,SRC). Based upon this estimated Koc, methylthiouracil will be expected to be highly mobile in soil(3,SRC) and will not be expected to significantly adsorb to soil, sediment or suspended particulate matter(3,SRC).

Due to a lack of data, the tendency for methylthiouracil to volatilize from water and moist near-surface soil cannot be estimated(SRC). Based upon a report that the compound readily sublimes(1), however, loss of methylthiouracil from surfaces and dry near-surface soil may occur via sublimation(SRC).

Exposure to methylthiouracil may occur via oral ingestion as a drug for the treatment of hyperthyroidism(1,2,SRC). Since no evidence was found that indicates that methylthiouracil has ever been produced commercially or that it is still used as a drug in the U.S.(2,SRC), exposure to methylthiouracil may be primarily via inhalation and dermal routes in occupational settings (if the chemical is currently being made and used)(SRC).

Antithyroid Agents|ANTITHYROID DRUGS ... ARE USED TO ... TREAT THYROTOXIC CRISIS, OR ARE GIVEN BEFORE OR AFTER RADIOACTIVE IODINE. /ANTITHYROID DRUGS/|UPON STOPPING TREATMENT, HYPERTHYROIDISM RETURNS PROMPTLY WITHIN 2 MONTHS IN ABOUT 20% OF PATIENTS.|... INCIDENCE OF PROGRESSIVE OPHTHALMOPATHY APPEARS TO BE SOMEWHAT LESS WITH DRUG THERAPY. /ANTITHYROID DRUGS/|For more Therapeutic Uses (Complete) data for METHYLTHIOURACIL (6 total), please visit the HSDB record page.

... INCIDENCE OF SIDE EFFECTS FROM METHYLTHIOURACIL IS APPROX SIX TIMES HIGHER THAN THAT FOR PROPYLTHIOURACIL.|SIDE EFFECTS OF DRUG ARE ... SIMILAR TO THOSE OF PROPYLTHIOURACIL ... MOST SERIOUS ... ARE GRANULAR LEUKOPENIA, DRUG FEVER, & DERMATITIS. JOINT PAINS & URTICARIA MAY OCCUR. CROSS-SENSITIVITY TO OTHER THIOURACILS MAY OCCUR.|... LESS FREQUENT COMPLICATIONS ARE ... PARESTHESIAS, HEADACHE, NAUSEA, & LOSS OR DEPIGMENTATION OF HAIR. ... HEPATITIS, & NEPHRITIS ARE VERY RARE. /THIOURACILS/|... ADMIN OF METHYL THIOURACIL IN TREATMENT OF HYPERTHYROIDISM WAS ASSOC WITH NYSTAGMUS & VISUAL ILLUSION OF MOVEMENT OF ENVIRONMENT, ACCOMPANYING SEVERE VERTIGO ... .|Methylthiouracil was reported to affect taste and smell. /From table/

Agents that are used to treat hyperthyroidism by reducing the excessive production of thyroid hormones. (See all compounds classified as Antithyroid Agents.)

FOLLOWING IV INJECTION OF 5 MG/RAT MTU, 84-90% OF DOSE ... RECOVERED FROM CARCASSES ... AFTER 1 MIN & 55-60% FROM CARCASSES OF ANIMALS KILLED AFTER 3 HR. AFTER 3 HR, CONCN OF MTU IN THYROID WAS APPROX 1 MG/G OF TISSUE.|ANTITHYROID DRUGS CROSS THE PLACENTA & CAN ALSO BE FOUND IN MILK. /ANTITHYROID DRUGS/

FORTY-EIGHT HR AFTER ORAL ADMIN OF RADIOACTIVE METHYLTHIOURACIL, METABOLITES EXCRETED IN RAT URINE WERE 6-METHYLURACIL, 6-METHYL-2-METHYLTHIOURACIL, 6-METHYL-4-OXOPYRIMIDINE, 2-AMINO-6-METHYL-4-OXOPYRIMIDINE & UREA.

THIOAMIDE DERIVATES /WHICH INCL METHYLTHIOURACIL/ ... INHIBIT HORMONE SYNTHESIS & SECRETION UNTIL SPONTANEOUS REMISSION OCCURS DURING COURSE OF DISEASE.

SYMPTOMS: Symptoms of ingestion of this type of compound may include skin rash, urticaria, fever, anorexia and malaise. It may also cause joint pains, sore throat and agranulocytosis. Other symptoms may include paresthesias, headache, nausea and loss or depigmentation of the hair. It may cause dermatitis and thirst. ACUTE/CHRONIC HAZARDS: This compound may cause skin irritation. When heated to decomposition this compound emits toxic fumes of carbon monoxide, carbon dioxide, NOx and SOx. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring. Recommendations from the physician will depend upon the specific compound, its chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure. (NTP, 1992)

A 36-YR OLD FEMALE WAS TREATED FOR HYPERTHYROIDISM THROUGH FIRST PERIOD OF PREGNANCY. FETUS REMOVED IN 5TH MONTH. THYROID GLAND OF FETUS WAS HYPERPLASTIC, WEIGHING 335 MG (NORMS UP TO 260 MG).|A 25 YR-OLD PREGNANT WOMAN SUFFERING FROM HYPERTHYROIDISM WAS TREATED WITH 600-100 MG/DAY UNTIL PARTURITION. SHE DEVELOPED A MARKED GOITER DURING THE TREATMENT; THERE WAS NO THYROID ENLARGEMENT IN HER CHILD.

4-Methyl-2-thiouracil

METHYLTHIOURACIL, NF, CAN BE OBTAINED IN 25- OR 50-MG TABLETS. ... THERE ARE NO COMMERCIAL PREPN AVAILABLE FOR PARENTERAL USE IN RARE EVENT THAT TREATMENT CANNOT BE GIVEN BY MOUTH.

4(1H)-Pyrimidinone, 2,3-dihydro-6-methyl-2-thioxo-: ACTIVE|S - indicates a substance that is identified in a final Significant New Use Rule.|/IT IS/ THE METHYL ANALOG OF PROPYLTHIOURACIL ... .

METHYLTHIOURACIL WAS ONE OF THE PHARMACEUTICALS EXAMINED BY HPLC.|GAS CHROMATOGRAPHIC PROCEDURE WAS DEVELOPED FOR THE DETERMINATION OF METHYLTHIOURACIL RESIDUES IN MEAT & ORGANS OF SLAUGHTERED ANIMALS.|Potentiometric titration is used for determination of methylthiouracil in pharmaceutical preparations. Thin layer chromatographic method can be used for determination in feed. This method is sensitive to 1 ug.

Pharmaceuticals -> Animal Drugs -> Approved in Taiwan