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Trimipramine maleate

Trimipramine maleate structure

CAS No:
521-78-8
Formula:
C20H26N2.C4H4O4
Chemical Name:
Trimipramine maleate
Synonyms:
5H-Dibenz[b,f]azepine-5-propanamine,10,11-dihydro-N,N,β-trimethyl-,(2Z)-2-butenedioate (1:1);5H-Dibenz[b,f]azepine,5-[3-(dimethylamino)-2-methylpropyl]-10,11-dihydro-,maleate (1:1);5H-Dibenz[b,f]azepine-5-propanamine,10,11-dihydro-N,N,β-trimethyl-,(Z)-2-butenedioate (1:1);Surmontil maleate;Trimeprimine maleate;Trimipramine acid maleate;Trimipramine maleate;Trimeprimine monomaleate;3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N,2-trimethylpropan-1-aminium acid maleate;117848-51-8;138145-72-9;1202867-12-6
Categories:
Chemical Reagents > Organic Reagents

Description

Trimipramine maleate is a 5-HT receptor antagonist, with pKis of 6.39, 8.10, 4.66 for 5-HT1C, 5-HT2 and 5-HT1A, respectively.

Tricyclic antidepressant similar to IMIPRAMINE, but with more antihistaminic and sedative properties.

Trimipramine maleate Basic Attributes

Molecular Weight：

410.51

Exact Mass：

410.220551

EC Number：

208-318-3

UNII：

D28E1043W5|I412286V22

NSC Number：

758386

DSSTox ID：

DTXSID2045315

HScode：

2933996100

Characteristics

PSA：

81.1

Density：

1.029g/cm3

Melting Point：

142 °C

Flash Point：

183.3ºC

Water Solubility：

>61.6 [ug/mL]

Collision Cross Section：

169.9 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Packing level：

Ⅲ

Hazard category：

6.1(b)

Transport codes：

2811

wgk germany：

hazard class code：

6.1

safety instructions：

26-36-45-33-24-16-7-36/37

RTECS Number：

HN9260000

Marks：

Xn,T,F

Precautionary statement(s)：

P280-P301 + P312 + P330-P305 + P351 + P338

Hazard Statements：

H302-H315-H319-H335-H361

Drug Information

MeSH：

Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. (See all compounds classified as Adrenergic Uptake Inhibitors.)|Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system. (See all compounds classified as Antidepressive Agents, Tricyclic.)

MeSH Entry Terms：

10,11 Dihydro-N,N,beta-trimethyl-5H-dibenz(b,f)azepine-5-propanamine

Trimipramine maleate Use and Manufacturing

Uses

Antidepressant;Noradrenaline uptake inhibitor Antidepressant; serotonin transport blocker that also blocks norepinephrine uptake

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:410.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:410.22055744
Monoisotopic Mass:410.22055744
Topological Polar Surface Area:81.1
Heavy Atom Count:30
Complexity:436
Undefined Atom Stereocenter Count:1
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Recommended Suppliers of Trimipramine maleate

Compound Net Biotechnology Inc. Contact Supplier

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Manufactory Supplier of 4-(Pentafluorothio)aniline,Pentafluoro,Pentafluorothio,Pentafluorosulfur,[4-(bromomethyl)phenyl]-pentafluoro-lambda6-sulfane,[4-(pentafluoro-sulfanyl)phenyl]acetic acid

521-78-8 (Z)-but-2-enedioic acid;3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N,2-trimethylpropan-1-amine

CAS No.: 521-78-8

Grade: Industrial Grade

Content: 95%

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