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Ferron

Ferron structure

CAS No:
547-91-1
Formula:
C9H6INO4S
Chemical Name:
Ferron
Synonyms:
5-Quinolinesulfonic acid,8-hydroxy-7-iodo-;8-Hydroxy-7-iodo-5-quinolinesulfonic acid;Ferron;Loretin;Meditrene;Quiniophen;Yellon;7-Iodo-8-hydroxylquinoline-5-sulfonic acid;Ferron (analytical reagent);7-Iodo-5-sulfonic acid-8-hydroxyquinoline;7-Iodo-8-hydroxyquinoline-5-sulfonic acid;8-Hydroxy-7-iodoquinoline-5-sulfonic acid;7-Iodo-8-quinolinol-5-sulfonic acid;5-Sulfo-7-iodo-8-hydroxyquinoline;7-Iodooxine-5-sulfonic acid;5-Sulfo-7-iodo-8-quinolinol;NSC 3784
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

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Description

yellow-green powder

Loretin is a hydroxyquinoline.

Ferron Basic Attributes

Molecular Weight：

351.12

Exact Mass：

351.12

EC Number：

208-938-4

UNII：

6E8Y02XFEI

NSC Number：

3784

DSSTox ID：

DTXSID1046136

ATC Code：

P - Antiparasitic products, insecticides and repellents

HScode：

2933499090

Characteristics

PSA：

95.9

XLogP3：

1.2

Density：

2.2±0.1 g/cm3

Melting Point：

260 °C (decomp)

Refractive Index：

1.776

Collision Cross Section：

165.5 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Packing level：

III

Hazard category：

Transport codes：

UN 2585 8/PG 3

wgk germany：

hazard class code：

safety instructions：

26-36/37/39-45

RTECS Number：

VC2800000

Marks：

Stability/Shelf Life：

Stable.

Precautionary statement(s)：

P280-P305 + P351 + P338-P310

Hazard Statements：

H314

GHS Classification：

|Danger|H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]|P260, P264, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P363, P405, and P501|Aggregated GHS information provided by 40 companies from 2 notifications to the ECHA C&L Inventory.

Drug Information

MeSH Entry Terms：

7-iodo-8-hydroxyquinoline-5-sulfonic acid

Ferron Use and Manufacturing

Uses

Used as an anti-amebic drug. It is a halogenated 8-hydroxyquinoline. Such anti-amebic drugs exert anti-amebic effects by inhibiting intestinal commensal bacteria, have an effect on amoebic dysentery, and have no effect on extra-intestinal amoebic protozoa. In recent years, it has been reported abroad that this class of drugs can cause subacute spinal cord neuropathy, so this drug has been banned in Japan and the United States.

Manufacturing Info：

5-Quinolinesulfonic acid, 8-hydroxy-7-iodo-: ACTIVE

Computed Properties

Molecular Weight:351.12
XLogP3:1.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:350.90623
Monoisotopic Mass:350.90623
Topological Polar Surface Area:95.9
Heavy Atom Count:16
Complexity:355
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

8-Hydroxyquinoline

Sulfuric acid

Sodium hypochlorite