Zinc stearate

349.85700

348.20100

209-151-9

H92E6QA4FV

0987

3077

DTXSID7027209

White powder free from gritiness|Fine, soft, bulky powder

29157090

37.30000

1.2

Zinc stearate is a white, hydrophobic powder with a slight, characteristic odor. Mp: 130°C. Density: 1.1 g cm-3. Insoluble in water, ethyl alcohol and diethyl ether. Soluble in acids. Non-toxic. In technical grades, the percentage of zinc may vary according to the intended use. Products with less than the theoretical amount of zinc are more acidic.

1.095 g/cm³

130 °C

359.4ºC at 760 mmHg

276ºC

Insoluble

Keep away from heat and flame. Store in a cool, dry place. Keep containers tightly closed.

0 mmHg (approx)

LD50 oral in rat: > 10gm/kg

Combustible Solid

vol% in air: 20

Faint odor

Neutral to moistened litmus paper

Decomp by dilute acids|Hydrophobic

No rapid reaction with air No rapid reaction with water

Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters

ZINC STEARATE is non-flammable but combustible. Incompatible with oxidizing agents, dilute acids. Emits acrid smoke and fumes of ZnO when heated to decomposition (Hazardous Chemicals Desk Reference, p. 865 (1987)).

788 °F (420 °C)|420 °C

Combustible Solid

Dust explosion possible if in powder or granular form, mixed with air. If dry, it can be charged electrostatically by swirling, pneumatic transport, pouring, etc.

NONH for all modes of transport

R37

S22-S26-S36/37/39-S38

ZH5200000

Xi

Stable. Incompatible with strong oxidizing agents.

P261, P271, P273, P304+P340, P312, P391, P403+P233, P405, P501

H335

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.|Observe all federal, state, and local environmental regulations. Contact a licensed professional waste disposal service to dispose of this material. Dispose contaminated packaging as unused product.

Oxidizers, dilute acids [Note: Hydrophobic (i.e., repels water)].

The substances listed in paragraph (b) of this section may be safely used as antioxidants and/or stabilizers in polymers used in the manufacture of articles or components of articles intended for use in producing, manufacturing, packing, processing, preparing, treating, packaging, transporting, or holding food, subject to the provisions of this section: (a) The quantity used shall not exceed the amount reasonably required to accomplish the intended technical effect. Zinc stearate is included on this list.|Zinc stearate prepared from stearic acid free from chick edema factor used as a nutrient in food for human consumption is generally recognized as safe when used in accordance with good manufacturing practice.|Drug products containing certain active ingredients offered over-the-counter (OTC) for certain uses. A number of active ingredients have been present in OTC drug products for various uses, as described below. However, based on evidence currently available, there are inadequate data to establish general recognition of the safety and effectiveness of these ingredients for the specified uses: zinc stearate is included in topical acne drug products.|Drug products containing certain active ingredients offered over-the-counter (OTC) for certain uses. A number of active ingredients have been present in OTC drug products for various uses, as described below. However, based on evidence currently available, there are inadequate data to establish general recognition of the safety and effectiveness of these ingredients for the specified uses: zinc stearate is included in topical astringent drug products.|Zinc stearate prepared from stearic acid free from chick edema factor is generally recognized as safe when used as a nutrient and/or dietary supplement in accordance with good manufacturing or feeding practice.

European Chemicals Bureau; Risk Assessment Report on Zinc Distearate, CAS-No.: 557-05-1, 91051-01-3. EINECS-No.: 209-151-9, 293-049-4. Part I-Environment (May 2008) and PartII-Human Health (2004). Risk assessment reports provide scientific support to the development and implementation of EU polices related to health and consumer protection.[Available from, as of March 24, 2011: http://ecb.jrc.ec.europa.eu/DOCUMENTS/Existing-Chemicals/RISK_ASSESSMENT/REPORT/zincdistearatereport074.pdf]|European Commission, ESIS; IUCLID Dataset, Zinc distearate (557-05-1) p.17 (2000 CD-ROM edition) contains information on use, toxicology, and environmental effects of this chemical as supplied to the European Union by industry.[Available from, as of February 7, 2011: http://esis.jrc.ec.europa.eu/]|Zinc and Health. Current Bibliographies in Medicine 98-3. Public Services Division/National Library of Medicine. 3619 citations January, 1990-June, 1998.[Available from, as of November 2, 1998: http://www.nlm.nih.gov/archive/20040831/pubs/cbm/zinc.html]

Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Finely dispersed particles form explosive mixtures in air.|Flammable - 2nd degree

|Warning|H335 (73.79%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]|P261, P271, P273, P304+P340, P312, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 2012 companies from 24 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|Not Classified|H316: Causes mild skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P304+P340, P305+P351+P338, P312, P332+P313, P337+P313, P403+P233, P405, and P501

Skin: No recommendation is made specifying the need for personal protective equipment for the body. Eyes: No recommendation is made specifying the need for eye protection. Wash skin: No recommendation is made specifying the need for washing the substance from the skin (either immediately or at the end of the work shift). Remove: No recommendation is made specifying the need for removing clothing that becomes wet or contaminated. Change: No recommendation is made specifying the need for the worker to change clothing after the work shift. (NIOSH, 2016)|Where risk assessment shows air-purifying respirators are appropriate use a dust mask type N95 (US) or type P1 (EN 143) respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).|Hand protection: Handle with gloves. Eye protection: Safety glasses with side-shields conforming to EN166 Skin and body protection: Choose body protection according to the amount and concentration of the dangerous substance at the work place.|(See protection codes)

Combustible when exposed to heat or flame.

The finely powdered soap is a significant dust explosion hazard.|Explosive limits , vol% in air: 20-?

Suitable extinguishing media. Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.|Special protective equipment for fire-fighters. Wear self contained breathing apparatus for fire fighting if necessary.|Water, foam, carbon dioxide, dry chemical.

ACCIDENTAL RELEASE MEASURES. Personal precautions: Use personal protective equipment. Avoid dust formation. Avoid breathing dust. Ensure adequate ventilation. Environmental precautions: Do not let product enter drains. Methods and materials for containment and cleaning up: Pick up and arrange disposal without creating dust. Keep in suitable, closed containers for disposal.

SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants. Ensure that the local ventilation moves the contaminant away from the worker.|Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.|Precautions for safe handling. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. Normal measures for preventive fire protection.|If breathed in, move person into fresh air. If not breathing give artificial respiration Consult a physician. In case of skin contact, wash off with soap and plenty of water. Consult a physician. In case of eye contact, rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed, never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

Permissible Exposure Limit: Table Z-1 8-Hr Time Weighted Avg: 15 mg/cu m. /Total dust/|Permissible Exposure Limit: Table Z-1 8-Hr Time Weighted Avg: 5 mg/cu m. /Respirable fraction/

Recommended Exposure Limit: 10 Hour Time-Weighted Average: 10 mg/cu m (total particulate)|Recommended Exposure Limit: 10 Hour Time-Weighted Average: 5 mg/cu m (respirable fraction)

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Evaporation at 20 °C is negligible; a nuisance-causing concentration of airborne particles can, however, be reached quickly.

NO open flames. Closed system, dust explosion-proof electrical equipment and lighting. Prevent deposition of dust. Prevent build-up of electrostatic charges (e.g., by grounding).

PREVENT DISPERSION OF DUST!

Avoid inhalation of dust and mist.

Wear safety goggles.

| 1 - Materials that, under emergency conditions, can cause significant irritation.| 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air.| 0 - Materials that in themselves are normally stable, even under fire conditions.

LD50 Rat ip 0.25 g/kg /SRP: 250mg/kg/|LD50 Rat oral >5000 mg/kg|LC50 Rat Inhalation >200 mg/L (1 hr)|LD50 Rabbit dermal >2000 mg/kg

/AQUATIC SPECIES/ The acute toxicity of zinc distearate to the waterflea Daphnia magna was determined according to OECD 202 in M7 medium at pH 6 and 8. Up to a loading rate of 100 mg zinc distearate/L the EC50 was not reached. The zinc concentration (detected using ICP-MS) at the beginning of the test was 1.2 mg Zn/L at pH 8 and 0.8 mg Zn/L at pH 6, at a loading rate of 100 mg zinc distearate/L. In the three available acute toxicity tests with fish, no effects were observed at nominal zinc distearate concentrations up to the water solubility limit or at nominal concentrations that were 3 to 4 orders of magnitude higher than the water solubility limit. From these data, although very limited, it is concluded that the ... acute toxicity of zinc distearate to Daphnia magna and fish is (far) above the water solubility limit of around 1 mg/L.

The use of zinc stearate in therapeutic applications will result in exposure in humans. (SRC)|According to the 2006 TSCA Inventory Update Report, the number of workers reasonably likely to be exposed in the industrial manufacturing, processing, and use of zinc stearate is greater than 1000 persons; the data may be greatly underestimated(1).|NIOSH (NOES Survey 1981-1983) has statistically estimated that 382,620 workers (136,358 of these were female) were potentially exposed to zinc stearate in the US(1).

Zinc stearate is a mild antiseptic and astringent, and it has been used as a local soothing application for inflammatory and irritating skin diseases.|Zinc stearate is primarily used in pharmacuetical formulations as a lubricant in tablet and capsule manufacture at concentrations up to 1.5% w/w.|In dental cement

... Its use as dusting powder for infants is not recommended.

In humans with no excessive intake of zinc, the body burden half-time of absorbed radio-labelled zinc has been observed to range from 162 to 500 days. After parenteral administration of 65Zn2+, half-times ranged from 100 to 500 days. /Zinc ions/|Within certain limits, mammals can maintain the total body zinc and the physiologically required levels of zinc in the various tissues constant, both at low and high dietary zinc intakes. The sites of regulation of zinc metabolism are: absorption of Zn2+ from the gastrointestinal tract, excretion of zinc in urine, exchange of zinc with erythrocytes, release of zinc from tissue, and secretion of zinc into the gastrointestinal tract. Regulation of gastrointestinal absorption and gastrointestinal secretion probably contributes the most to zinc homeostasis. /Zinc ions/

Zinc is mostly bound to organic ligands rather than free in solution as a cation. Zinc is found in diffusible and non-diffusible forms in the blood and about 66% of the diffusible form of zinc in the plasma is freely exchangeable and loosely bound to albumin. A small amount of the non-diffusible form of zinc is tightly bound to 2-macroglobulin in the plasma and is not freely exchangeable with other zinc ligands. Zinc is incorporated into and dissociated from alpha2-macroglobulin only in the liver. /Zinc ions/

In humans with no excessive intake of zinc, the body burden half-time of absorbed radio-labelled zinc has been observed to range from 162 to 500 days. After parenteral administration of 65Zn2+, half-times ranged from 100 to 500 days. /Zinc ions/

Exposure Routes: inhalation, ingestion, skin and/or eye contact Symptoms: Irritation eyes, skin, upper respiratory system; cough Target Organs: Eyes, skin, respiratory system (NIOSH, 2016)

Eye: If this chemical contacts the eyes, immediately wash the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately. Contact lenses should not be worn when working with this chemical. Skin: If this chemical contacts the skin, wash the contaminated skin with soap and water. Breathing: If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. Other measures are usually unnecessary. Swallow: If this chemical has been swallowed, get medical attention immediately. (NIOSH, 2016)|(See procedures)

Fresh air, rest. Refer for medical attention.

Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

/SRP:/ Immediate first aid: Remove patient from contact with the material. Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Zinc and related compounds/|/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Anticipate seizures and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Zinc and related compounds/|/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine, hydrochloride to assist eye irrigation ... . /Zinc and related compounds/

/HUMAN EXPOSURE STUDIES/ Two eyeshadow formulations, each containing 10% zinc stearate, were tested by means of the Schwartz-Peck Prophetic Patch Test and the Draize-Shelanski Repeated Insult Patch Test. The former test resulted in "virtually 0 reactions in 202 subjects," whereas the latter one brought about "virtually 0 reactions in 99 subjects." One of the formulations was applied twice a day for 28 days to 52 female panelists. Each subject was then examined at baseline and one, two, three, and four weeks after application. No irritation or sensitization potential was exhibited by the panelists using this product under conditions of this test.|/CASE REPORTS/ A clinical study of 12 cases of aspiration of zinc-stearate dust in infants was reported. Three infants developed bronchopneumonia with symptoms of acute toxemia which lasted for 2 to 3 weeks. Rapid breathing, rapid pulse rate, and marked cyanosis were observed. Abdominal distension was marked in two cases. In eight cases, there was initial partial asphyxia followed by lung involvement. Necropsy of an 8 month old infant did not reveal significant gross morphology, but microscopically areas of interstitial round cell infiltration were observed. The bronchioles showed round and polymorphonuclear leukocytic infiltration of walls.|/CASE REPORTS/ ... Pneumoconiosis with probable heart failure /was observed/ in a rubber factory worker who had been occupationally exposed to zinc stearate dust for 29 years. Histological examination of lungs revealed bleeding, a significant increase in connective tissue, and chronic inflammation; likewise, numerous "granules and needles" in the fibrotic tissue that contained zinc were also observed.|/CASE REPORTS/ ... A case of pulmonary fibrosis in a chemical worker who had been occupationally exposed to zinc stearate dust for seven years /is described/. The amount of zinc retained in the lungs of the deceased worker (6.2 mg/100 g of dry lung tissue) was not significantly different than that retained in the lungs of persons who had not been occupationally exposed. It was the authors' opinion that zinc stearate was not the cause of lung fibrosis.|For more Human Toxicity Excerpts (Complete) data for ZINC STEARATE (8 total), please visit the HSDB record page.

aluminum monostearate

The substance can be absorbed into the body by inhalation of its aerosol.|inhalation, ingestion, skin and/or eye contact

irritation eyes, skin, upper respiratory system; cough

Cough.

Eyes, skin, respiratory system

Table: Distribution and EU tonnage for the different use categories of zinc distearate in the EU for 1997 [Table#827]

Zinc stearate USP; 60 g and 125 g shaker containers.|Grades: USP, technical, available from chick edema factor.|HyTech, HyDense, HyQual, RSN 131-HS, Wettable powder; DZS-36, SI-50, IPS, granular; XM powder; XM ultrafine dispersion SP grades; USP|Usually occurs as mixture of zinc salts of stearic and palmitic acids, and usually with some excess of zinc oxide. Contains 13.5-15% zinc oxide.

Adhesive manufacturing|Octadecanoic acid, zinc salt (2:1): ACTIVE|Polymer industry. Zinc distearate is typically added during the melt compounding process (all types of plastics and polymer masterbatches) or during the preparation of dry blends with polymer powders (e.g. PVC), pellets or beads (expandable polystyrene). Zinc distearate is added at low levels of smaller than 0.1 % of the final product in polystyrene, expandable polystyrene, some engineering plastics and some polyolefins (mould release / lubrication). Zinc distearate is used at higher concentrations (up to a few percent) as a component of (calcium/zinc) stabilisers in some PVC applications. All these processes are dry and are conducted in closed vessels or pipe work (industrial information).|Paints, lacquers and varnishes industry. Zinc distearate is used in furniture coatings as clear lacquers for industrial application on wood, seales and multicoatings, 2-pack polyurethane fillers, nitrocellulose fillers and lacquers and polyester primers. The content of zinc distearate in these products is 0.5-8 %. The split between solvent borne coatings and waterborne coatings is about 90:10.|Building industry. In the building or construction industry zinc distearate is used as a hydrophobic agent for the production of plaster. In this process zinc distearate is mixed together with cement, lime sand and other ingredients in powder form. The dry mortar will be mixed with water at the building site. In pre-mixtures the zinc distearate content is about 20%, the average dose of zinc distearate is about 0.3% (0.03% zinc metal).|Paper industry. Zinc stearate is used in the manufacture of thermal sensitive papers. These papers are used in fax machines, point of sale receipts and labels. The chemical mixture (incl. zinc stearate) acts as a slip agent preventing the paper from sticking to the print head of the imaging equipment. The mixture is purchased by the paper industry in powder form which are further mixed and ground to form an aqueous emulsion and blended with other chemicals to form a mix suitable for application to the paper.|For more General Manufacturing Information (Complete) data for ZINC STEARATE (6 total), please visit the HSDB record page.

Fire Hazards -> Flammable - 2nd degree|Cosmetics -> Anticaking; Cosmetic colorant