Zinc acetate

183.48

181.955750

209-170-2

H2ZEY72PME

3077

DTXSID8038770

Exists in two crystalline forms, alpha (wurtzite) and beta (sphalerite)|White to grayish-white or yellowish powder colorless cubic crystals

A - Alimentary tract and metabolism

2915299090

80.3

0.08840

Yellow to brown to gray-green Powder

1.735 g/cm³

237 °C (decomp)

242-4ºC

12 °C

soluble in water, alcohol, dilute mineral acids and alkalies.

Finely divided zinc compounds, can be fire and explosion hazard if stored in damp places, sources of spontaneous combustion. /Zinc cmpd/

Changes to alpha form at 1020 °C; sublimes at 1180 °C /beta/|White powder; mp: 237 °C (decomposes); density: 1.735 g/cu cm; solubility: 30.0 g/100 g water at 20 °C; soluble in ethanol /Zinc acetate dihydrate/|Heat of solution: -0.5 Btu/lb= -0.3 cal/g= -0.01X10+5 J/kg|White, monoclinic, crystalline plates; pearly luster; loses 2H2O at 100 °C /Zinc acetate dihydrate/|Crystallizes from dilute acetic acid; faint, acetous odor; astringent taste; slightly efflorescent; the aqueous solution is neutral to slightly acid to litmus; pH about 5-6 /Zinc acetate dihydrate/

Water soluble.

Salts, Basic

Salts, basic, such as ZINC ACETATE, are generally soluble in water. The resulting solutions contain moderate concentrations of hydroxide ions and have pH's greater than 7.0. They react as bases to neutralize acids. These neutralizations generate heat, but less or far less than is generated by neutralization of the bases in reactivity group 10 (Bases) and the neutralization of amines. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible.

9

UN 3077 9/PG 3

3

36-50/53-22-11

26-60-61-39-16-7

AK1500000

Xn,N,Xi,F

Stable. Incompatible with alkalies, strong oxidizing agents.

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.|Chemical Treatability of Zinc; Concentration Process: Ultrafiltration; Chemical Classification: Metals; Scale of Study: Continuous flow, pilot scale; Type of Wastewater Used: Industrial wastewater; Results of Study: 0.38 ppm effluent concentration. /Zinc/|Chemical Treatability of Zinc; Concentration Process: Miscellaneous sorbents; Chemical Classification: Metals; Scale of Study: Literature review; Type of Wastewater Used: Unknown; Results of Study: Final concentration reduced to 0.1 ppb; SiO2 + CaO slags used. /Zinc/|The proprietary Sulfex process (Permutit Co) has been applied to zinc wastes. The process involves addition of ferrous sulfide, which gradually releases sulfide to precipitate the zinc ... . /Zinc/|For more Disposal Methods (Complete) data for ZINC ACETATE (11 total), please visit the HSDB record page.

Incompatible with zinc salts, alkalies and their carbonates, oxalates, phosphates, and sulfides.

Zinc acetate is an indirect food additive for use only as a component of adhesives.|Trace minerals added to animal feeds as nutritional dietary supplements are generally recognized as safe when added at levels consistent with good feeding practice. Zinc acetate is included on this list.|The Approved Drug Products with Therapeutic Equivalence Evaluations List identifies currently marketed prescription drug products, incl zinc acetate, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act.|Drug products containing certain active ingredients offered over-the-counter (OTC) for certain uses. A number of active ingredients have been present in OTC drug products for various uses, as described below. However, based on evidence currently available, there are inadequate data to establish general recognition of the safety and effectiveness of these ingredients for the specified uses: zinc acetate is included in skin protectant drug products (wound healing claims only).|Drug products containing certain active ingredients offered over-the-counter (OTC) for certain uses. A number of active ingredients have been present in OTC drug products for various uses, as described below. However, based on evidence currently available, there are inadequate data to establish general recognition of the safety and effectiveness of these ingredients for the specified uses: zinc acetate is included in diaper rash products.

|Danger|H302 (69.14%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P273, P280, P301+P312, P305+P351+P338, P310, P330, P337+P313, P391, and P501|Aggregated GHS information provided by 591 companies from 23 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P280, P301+P312, P305+P351+P338, P310, P330, and P501

Bu. Mines approved respirator; rubber gloves; chemical goggles (USCG, 1999)|... Recommended appropriate protective equipment including protective eyewear, long-sleeved shirts and long-legged pants, rubber gloves, and boots. /zinc salts/|/NISOH certified respirator/; Rubber gloves; Chemical goggles.

Not flammable

If material on fire or involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material does not burn or burns with difficulty.)

Environmental considerations: Land spill: Dig a pit, pond, lagoon, or holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be contained with a flexible impermeable membrane liner./ Cover solids with a plastic sheet to prevent dissolving in rain or fire fighting water.|Environmental considerations: Water spill: Neutralize with agricultural lime (CaO), crushed limestone, or sodium bicarbonate. Add soda ash. Adjust pH to neutral (pH 7). Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates or greater concentration.

If material not on fire and not involved in fire: Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Keep up wind. Avoid breathing vapors or dusts. Wash away any material which may have contacted the body with copious amounts of water or soap and water.|SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.|Prevention ... /of metal fume fever/ is a matter of keeping exposure of workers below level of concn currently accepted as satisfactory for working with the metal in industry, preferably by employment of proper local exhaust ventilation to collect fumes at their source. Acceptable respirators are avail commercially but should be used only under suitable conditions. /Zinc/|In all cases where zinc is heated to the point where fume is produced, it is most important to ensure that adequate ventilation is provided. Individual protection is best ensured by education of the worker concerning metal-fume fever & the provision of local exhaust ventilation, or, in some situations by wearing of supplied-air hood or mask.

Zinc salts of strong mineral acids are astringent, corrosive to skin ... /Zinc salts/|The dust is irritating to eyes, nose and throat. The solid is irritating to skin and eyes.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 1,000 lb or 454 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

According to the Toxnet database of the U.S. National Library of Medicine, the oral LD50 for zinc is close to 3 g/kg body weight, more than 10-fold higher than cadmium and 50-fold higher than mercury. The LD50 values of several zinc compounds (ranging from 186 to 623 mg zinc/kg/day) have been measured in rats and mice.

Organic zinc salts such as zinc aspartate, zinc orotate, zinc histidine and zinc acetate protected mice against the lethality of an acute intraperitoneal challenge with ethanol. A similar activity was also provided by salts of cobalt, zirconium, lithium, and magnesium. Organic zinc salts acted synergistically with sulfhydryl compounds in protecting the mice and potentiation between the two categories of agents was seen.|The effect of zinc on mercuric chloride induced lipid peroxidation in the rat kidney was investigated. The rats received zinc acetate (2.0 nmol/kg, po) for 2 days before being given mercuric chloride (15 umol/kg, sc) and were killed 6, 12, and 24 hr after the last injection. Lipid peroxidation occurred in the rat kidney 12 hr after mercury administration, and this mercury induced lipid peroxidation was significantly reduced by zinc pretreatment. A decrease in vitamin C and E contents in the kidney was observed 12 hr after the administration of mercury, and this decrease was prevented by zinc pretreatment. In the kidney of rats pretreated with zinc, the activities of the protective enzymes, glutathione peroxidase and glucose-6-phosphate dehydrogenase, were increased after mercury injection. Non-protein sulfhydryl content (mostly glutathione) also rose markedly.|In comparison with similar experiments in which no zinc acetate was used, the addition of small amounts of zinc acetate to sodium N-methyl-N-dithiocarboxyglucamine produces a significant increase in the amount of cadmium mobilized from the liver and kidneys of mice loaded ip with 10 mg cadmium chloride/kg 2 wk prior to the initiation of treatment. Neither treatment results in the transport of significant amounts of cadmium to the brain. The injection of zinc acetate alone did not produce this effect. Experiments in which zinc acetate in drinking water was administered to cadmium loaded animals showed that the liver and kidney cadmium levels were significantly increased, presumably via zinc mediated processes.|Wistar rats were injected (ip) either with 5 mg cis-diamminedichloro-platinum-II (cis-DDP)/kg, or pretreated with zinc acetate and then injected with cis-DDP. The zinc pretreatment significantly increased the binding of zinc (Zn) and copper (Cu) to both the renal and hepatic metallothioneins, but the proportion of cytosolic platinum associated with metallothioneins in the kidney tissue slightly reduced, and that in the liver showed no difference in comparison to rats treated with cis-diamminedichloro-platinum-II only. The results indicate that an increased cis-diamminedichloro-platinum-II biosynthesis the zinc pretreatment may not correspondingly increase the binding of intracellular Pt to cis-diamminedichloro-platinum-II. In the zinc acetate pretreated rats, the renal tissue and subellular Pt levels were significantly lower (p less than 0.01) than those in untreated rats, although the liver levels showed practically no difference.|For more Interactions (Complete) data for ZINC ACETATE (9 total), please visit the HSDB record page.

LD50 Rat oral 237 mg Zn/kg /From table/|LD50 Rat oral 2510 mg Zn acetate/kg|LD50 Mouse oral 86 mg Zn/kg /From table/|LD50 Mouse ip 57 mg/kg

Approximately 60-70% of the zinc in circulation is bound to albumin. Any condition that alters serum albumin concentration may have a secondary effect on serum zinc levels,.

Zinc can be used for the treatment and prevention of zinc deficiency/its consequences, including stunted growth and acute diarrhea in children, and slowed wound healing. It is also utilized for boosting the immune system, treating the common cold and recurrent ear infections, as well as preventing lower respiratory tract infections.

/Zinc acetate USP is used as/ an astringent in low concentrations and an irritant at high concentrations. It also has mild antibacterial actions similar to those of zinc sulfate. When applied to cuts, it exerts styptic action. After oral ingestion ... .|THERAP CAT: Styptic, astringent|THERAP CAT (VET): Antiseptic, astringent, protective (topical)|Orally administered zinc inhibits copper absorption through the intestine. Oral zinc /acetate/ therapy /for Wilson's disease/ is probably a safe and effective maintenance treatment for patients who were initially treated with chelating agents, and seems to be an appropriate first-line therapy for presymptomatic and pregnant patients. Combination drug therapy of a chelating agent and zinc has no advantages when compared with zinc only, during maintenance therapy.|For more Therapeutic Uses (Complete) data for ZINC ACETATE (9 total), please visit the HSDB record page.

Zinc does appear in breast milk and zinc-induced copper deficiency in the nursing baby may occur. Therefore, it is recommended that women on zinc therapy not nurse their babies.|Transient elevations in serum amylase, lipase, and alkaline phosphatase have been observed in patients with Wilson's disease receiving zinc acetate therapy (25 or 50 mg elemental zinc 3 times daily) ... Whether the increase in these enzyme levels in serum is indicative of pancreatic injury remains questionable.|FDA Pregnancy Risk Category: A /CONTROLLED STUDIES SHOW NO RISK. Adequate, well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester of pregnancy./|If this drug is used during pregnancy, the possibility of fetal harm appears remote. Because studies cannot rule out the possibility of harm, however, zinc acetate should be used during pregnancy only if clearly needed. While zinc acetate should be used during pregnancy only if clearly needed, copper toxicosis can develop during pregnancy if anti-copper therapy is stopped.|For more Drug Warnings (Complete) data for ZINC ACETATE (7 total), please visit the HSDB record page.

Zinc is involved in various aspects of cellular metabolism. It has been estimated that approximately 10% of human proteins may bind zinc, in addition to hundreds of proteins that transport and traffic zinc. It is required for the catalytic activity of more than 200 enzymes, and it plays a role in immune function wound healing, protein synthesis, DNA synthesis, and cell division. Zinc is an essential element for a proper sense of taste and smell and supports normal growth and development during pregnancy, childhood, and adolescence. It is thought to have antioxidant properties, which may be protective against accelerated aging and helps to speed up the healing process after an injury; however, studies differ as to its effectiveness. Zinc ions are effective antimicrobial agents even if administered in low concentrations. Studies on oral zinc for specific conditions shows the following evidence in various conditions: **Colds:** Evidence suggests that if zinc lozenges or syrup are taken within 24 hours after cold symptoms start, the supplement may shorten the length of colds. The use intranasal zinc has been associated with the loss of the sense of smell, in some cases long-term or permanently. **Wound healing:** Patients with skin ulcers and decreased levels of zinc may benefit from oral zinc supplements. **Diahrrea**: Oral zinc supplements can reduce the symptoms of diarrhea in children with low levels of zinc, especially in cases of malnutrition.

Zinc is absorbed in the small intestine by a carrier-mediated mechanism. Under regular physiologic conditions, transport processes of uptake do not saturate. The exact amount of zinc absorbed is difficult to determine because zinc is secreted into the gut. Zinc administered in aqueous solutions to fasting subjects is absorbed quite efficiently (at a rate of 60-70%), however, absorption from solid diets is less efficient and varies greatly, dependent on zinc content and diet composition. Generally, 33% is considered to be the average zinc absorption in humans. More recent studies have determined different absorption rates for various populations based on their type of diet and phytate to zinc molar ratio. Zinc absorption is concentration dependent and increases linearly with dietary zinc up to a maximum rate. Additionally zinc status may influence zinc absorption. Zinc-deprived humans absorb this element with increased efficiency, whereas humans on a high-zinc diet show a reduced efficiency of absorption.|The excretion of zinc through gastrointestinal tract accounts for approximately one-half of all zinc eliminated from the body. Considerable amounts of zinc are secreted through both biliary and intestinal secretions, however most is reabsorbed. This is an important process in the regulation of zinc balance. Other routes of zinc excretion include both urine and surface losses (sloughed skin, hair, sweat). Zinc has been shown to induce intestinal metallothionein, which combines zinc and copper in the intestine and prevents their serosal surface transfer. Intestinal cells are sloughed with approximately a 6-day turnover, and the metallothionein-bound copper and zinc are lost in the stool and are thus not absorbed. Measurements in humans of endogenous intestinal zinc have primarily been made as fecal excretion; this suggests that the amounts excreted are responsive to zinc intake, absorbed zinc and physiologic need. In one study, elimination kinetics in rats showed that a small amount of ZnO nanoparticles was excreted via the urine, however, most of the nanoparticles were excreted via the feces.|A pharmacokinetic study was done in rats to determine the distribution and other metabolic indexes of zinc in two particle sizes. It was found that zinc particles were mainly distributed to organs including the liver, lung, and kidney within 72 hours without any significant difference being found according to particle size or rat gender.|In one study of healthy patients, the clearance of zinc was found to be 0.63 ± 0.39 μg/min.|Zinc salts are not equal in solubility, which is important in zinc absorption. The solubility of zinc salts is affected by gastric pH. Healthy subjects were given a single oral dose of 50 mg elemental zinc as the acetate ... under either high (pH > 5) or low (pH < 3) intragastric pH conditions. The mean plasma zinc area under the curve for zinc acetate at low pH (AL) /and/ ... at high pH (AH) ... were 524 /and/ 378 ... ug/hr/dL ...|Absorption /of zinc acetate/ by the GI tract is variable in animals and poor in humans. Accumulation occurred in the liver and pancreas. Some regulation of intake and output of zinc probably takes place in the intestines. In rats and mice, metallothionein, a low-molecular-mass cytoplasmic metalloprotein, takes considerable part in this process. Excreted predominantly with feces. Urinary excretion is negligible.|In a study with human volunteers, most of the zinc in a zinc acetate solution (0.1 mmol/L) administered by intestinal perfusion was absorbed from the jejunum, followed by the duodenum and the ileum (357, 230 or 84 nmol/ liter per min per 40 cm respectively). The absorption showed a linear increase at concentrations of 0.1- 1.8 mmol/ L.|The absorption of zinc from soluble zinc acetate, zinc sulfate ... and insoluble zinc oxide was compared in ten human volunteers who were dosed orally with 50 mg Zn in various forms separated by two weeks intervals. Bioavailability of zinc from the various forms was compared on the basis of plasma zinc levels and area under the plasma curve (AUC) analysis. Plasma peak levels were observed after about 2.5 hours for all forms, but maximal plasma Zn concentration amounted to 221 and 225 ug/dL for the acetate and the sulphate form while the peak plasma level for Zn from the oxide was only 159 ug/dL. When AUC values for the different zinc forms were compared, it appeared that the bioavailability of zinc oxide was about 60% of the bioavailability of the soluble forms. /Zinc salts/

Zinc is released from food as free ions during its digestion. These freed ions may then combine with endogenously secreted ligands before their transport into the enterocytes in the duodenum and jejunum.. Selected transport proteins may facilitate the passage of zinc across the cell membrane into the hepatic circulation. With high intake, zinc may also be absorbed through a passive paracellular route. The portal system carries absorbed zinc directly into the hepatic circulation, and then it is released into systemic circulation for delivery to various tissues. Although, serum zinc represents only 0.1% of the whole body zinc, the circulating zinc turns over rapidly to meet tissue needs.

The half-life of zinc in humans is approximately 280 days.

**Zinc has three primary biological roles**: _catalytic_, _structural_, and _regulatory_. The catalytic and structural role of zinc is well established, and there are various noteworthy reviews on these functions. For example, zinc is a structural constituent in numerous proteins, inclusive of growth factors, cytokines, receptors, enzymes, and transcription factors for different cellular signaling pathways. It is implicated in numerous cellular processes as a cofactor for approximately 3000 human proteins including enzymes, nuclear factors, and hormones. Zinc promotes resistance to epithelial apoptosis through cell protection (cytoprotection) against reactive oxygen species and bacterial toxins, likely through the antioxidant activity of the cysteine-rich metallothioneins. In HL-60 cells (promyelocytic leukemia cell line), zinc enhances the up-regulation of A20 mRNA, which, via TRAF pathway, decreases NF-kappaB activation, leading to decreased gene expression and generation of tumor necrosis factor-alpha (TNF-alpha), IL-1beta, and IL-8. There are several mechanisms of action of zinc on acute diarrhea. Various mechanisms are specific to the gastrointestinal system: zinc restores mucosal barrier integrity and enterocyte brush-border enzyme activity, it promotes the production of antibodies and circulating lymphocytes against intestinal pathogens, and has a direct effect on ion channels, acting as a potassium channel blocker of adenosine 3-5-cyclic monophosphate-mediated chlorine secretion. Cochrane researchers examined the evidence available up to 30 September 2016. Zinc deficiency in humans decreases the activity of serum _thymulin_ (a hormone of the thymus), which is necessary for the maturation of T-helper cells. T-helper 1 (Th(1)) cytokines are decreased but T-helper 2 (Th(2)) cytokines are not affected by zinc deficiency in humans. The change of _Th(1)_ to _Th(2)_ function leads to cell-mediated immune dysfunction. Because IL-2 production (Th(1) cytokine) is decreased, this causes decreased activity of natural-killer-cell (NK cell) and T cytolytic cells, normally involved in killing viruses, bacteria, and malignant cells. In humans, zinc deficiency may lead to the generation of new CD4+ T cells, produced in the thymus. In cell culture studies (HUT-78, a Th(0) human malignant lymphoblastoid cell line), as a result of zinc deficiency, nuclear factor-kappaB (NF-kappaB) activation, phosphorylation of IkappaB, and binding of NF-kappaB to DNA are decreased and this results in decreased Th(1) cytokine production. In another study, zinc supplementation in human subjects suppressed the gene expression and production of pro-inflammatory cytokines and decreased oxidative stress markers. In HL-60 cells (a human pro-myelocytic leukemia cell line), zinc deficiency increased the levels of TNF-alpha, IL-1beta, and IL-8 cytokines and mRNA. In such cells, zinc was found to induce A20, a zinc finger protein that inhibited NF-kappaB activation by the tumor necrosis factor receptor-associated factor pathway. This process decreased gene expression of pro-inflammatory cytokines and oxidative stress markers. The exact mechanism of zinc in acne treatment is poorly understood. However, zinc is considered to act directly on microbial inflammatory equilibrium and facilitate antibiotic absorption when used in combination with other agents. Topical zinc alone as well as in combination with other agents may be efficacious because of its anti-inflammatory activity and ability to reduce P. acnes bacteria by the inhibition of P. acnes lipases and free fatty acid levels.|The active moiety in zinc acetate is zinc cation. Regardless of the ligand, zinc blocks the intestinal absorption of copper from the diet and the reabsorption of endogenously secreted copper such as that from the saliva, gastric juice and bile. Zinc induces the production of metallothionein in the enterocyte, a protein that binds copper thereby preventing its serosal transfer into the blood. The bound copper is then lost in the stool following desquamation of the intestinal cells.|The mechanism of zinc's anticopper action is unique. It induces intestinal cell metallothionein, which binds copper and prevents its transfer into blood. As intestinal cells die and slough, the contained copper is eliminated in the stool. Thus, zinc prevents the intestinal absorption of copper.

Inhalation causes mild irritation of nose and throat, coughing, and sneezing. Ingestion can cause irritation or corrosion of the alimentary tract, resulting in vomiting. Contact with dust causes irritation of eyes and mild irritation of skin. (USCG, 1999)

INHALATION: move to fresh air; if exposure is severe, get medical attention. INGESTION: induce vomiting, followed by prompt and complete gastric lavage, cathartics, and demulcents. EYES: flush with water for at least 10 min.; consult physician if irritation persists. SKIN: wash with soap and water. (USCG, 1999)

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Anticipate seizures and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Zinc and related compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or has severe pulmonary edema. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluids cautiously. Consider vasopressors for hypotension with a normal fluid volume. Watch for signs of fluid overload ... . Treat seizures with diazepam ... . Use proparacaine, hydrochloride to assist eye irrigation ... . /Zinc and related compounds/|... In the majority of cases, intoxication by ingested zinc salts or inhaled zinc fumes is a self-limiting disease. Symptomatic relief from pain and supportive therapy is all that is medically indicated in the common case. Chelating agents, such as calcium disodium ethylenediaminetetraacetic acid (EDTA), which are used in chelating zinc from the bloodstream, rarely are indicated. /Zinc salts/|Treatment for acute zinc toxicity is supportive. After oral ingestion of zinc or zinc salts, treatment should be directed toward control of nausea, vomiting, and diarrhea. Induced emesis, gastric lavage, or activated charcoal usually are unnecessary but may be useful in cases of substantial ingestion of zinc tablets of capsules. ...Treatment of zinc-induced copper deficiency requires discontinuation of supplemental zinc and therapy with oral or iv copper if necessary. /Zinc or zinc salts/|For more Antidote and Emergency Treatment (Complete) data for ZINC ACETATE (6 total), please visit the HSDB record page.

/HUMAN EXPOSURE STUDIES/ Researchers/ exposed groups of eight healthy women to 0, 15, 50, or 100 mg supplemental zinc as zinc acetate daily for 60 days (approximately 0, 0.25, 0.83, or 1.7 mg supplemental Zn/kg-day, assuming a reference female body weight of 60 kg) and evaluated effects on serum zinc and cholesterol levels. Zinc exposure resulted in significant, dose-related increases in serum zinc. In the highest exposure group only, plasma HDL-cholesterol was significantly reduced at 4 weeks of exposure, but not at any other timepoint examined. A direct correlation between dietary zinc and whole-blood copper was observed in treated subjects. The study authors noted that in the 50 and 100 mg groups, some bloating, nausea, and abdominal cramps were noted unless the supplement was taken with a large glass of water at mealtime.|/SIGNS AND SYMPTOMS/ ... Metal fume fever results from inhalation of fumes of zinc oxide produced when zinc is heated to high temperatures, such as during welding, metal cutting, or smelting zinc alloys. Victims complain of nausea and vomiting, chills and fever, muscular aches and pains, and weakness.

Anhydrous Zinc Acetate

(2001) 1410 thousand metric tons zinc. /Apparent, all forms/|(2002) 1420 thousand metric tons zinc. /Apparent, all forms/|(2003) 1340 thousand metric tons zinc. /Apparent, all forms/|(2004) 1400 thousand metric tons zinc. /Apparent, all forms/|(2005) 1370 thousand metric tons zinc. /Apparent, all forms/

REAGENT, 99%; COMMERCIAL, 98.4%|USP, reagent, & technical grades /Dihydrate/|ACS, USP, technical, crystal grades; liquid grade, high purity, ready to use; crystal & anhydrous crystal form, technical grade|GALZIN, Zinc Acetate Capsules (25 mg zinc content) are #1 capsules with aqua blue opaque cap and body, imprinted "93-215." Packaged in bottles of 250 (NDC 57844-215-52). GALZIN, Zinc Acetate Capsules (50 mg zinc content) are #1 capsules with orange opaque cap and body, imprinted "93-208." Packaged in bottles of 250 (NDC 57844-208-52).

Petrochemical manufacturing|Acetic acid, zinc salt (2:1): ACTIVE

Analyte: zinc acetate; matrix: chemical identification; procedure: reaction with sodium acetate or ammonium sulfide yields a white precipitate, with hydrogen sulfide, that is insoluble in acetic acid but soluble in hydrochloric acid; reaction with potassium ferricyanide yields a white precipitate that is insoluble in hydrochloric acid (zinc test)|Analyte: zinc acetate; matrix: chemical identification; procedure: reaction with sulfuric acid and alcohol yields ethyl acetate with its characteristic odor; reaction with ferric chloride produces a deep red color that is destroyed by the addition of mineral acids (acetate test)|Analyte: zinc acetate; matrix: chemical purity; procedure: dissolution in water; addition of ammonia-ammonium chloride buffer solution and eriochrome black indicator; titration with edetate disodium to a deep blue color

Food additives|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Cosmetics -> Antimicrobial