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Pheniramine maleate

Pheniramine maleate structure

CAS No:
132-20-7
Formula:
C16H20N2.C4H4O4
Chemical Name:
Pheniramine maleate
Synonyms:
2-Pyridinepropanamine,N,N-dimethyl-γ-phenyl-,(2Z)-2-butenedioate (1:1);Pyridine,2-[α-[2-(dimethylamino)ethyl]benzyl]-,maleate (1:1);Prophenpyridamine maleate;2-Pyridinepropanamine,N,N-dimethyl-γ-phenyl-,(Z)-2-butenedioate (1:1);Daneral;2-[α-[2-(Dimethylamino)ethyl]benzyl]pyridine bimaleate;Pheniramine maleate;1-Phenyl-1-(2-pyridyl)-3-dimethylaminopropane maleate;Trimetose;1-Phenyl-1-(2-pyridyl)-3-dimethaminopropane maleinate;Inhiston;Metron;PM 241;Pheniramine hydrogen maleate;Naphcon A;Trimeton;Antolozine;155683-11-7
Categories:
Active Pharmaceutical Ingredients > Antiallergic Drugs

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Description

Pheniramine Maleate ia an antihistamine and vasoconstrictor.

Pheniramine maleate Basic Attributes

Molecular Weight：

356.42

Exact Mass：

356.173615

EC Number：

205-051-4

Characteristics

PSA：

90.7

XLogP3：

2.87700

Appearance：

Pheniramine maleate is a white powder with a faint amine-like odor. Melting point 107°C. pH (1% solution) 4.5-5.5. Used medicinally as an antihistamine.

Melting Point：

107 °C

Boiling Point：

348.3°C at 760 mmHg

Flash Point：

164.5ºC

Water Solubility：

H2O: >=1 g/100 mL at 24 ºC

Storage Conditions：

Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Vapor Pressure：

5.07E-05mmHg at 25°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

safety instructions：

RTECS Number：

UT0175000

Marks：

Stability/Shelf Life：

Stable. Incompatible with strong oxidizing agents.

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

Pheniramine maleate Use and Manufacturing

Methods of Manufacturing

The reaction vessel was added with 50 ml of ethanol, 5 g of Pheniramine was stirred and dissolved, and 2.9 g of maleic acid was added and stirred at room temperature, and the mixture was filtered, and dried under vacuum at 45 °C to obtain Pheniramine maleate 5.1 g.The reaction vessel was added with 50 ml of ethanol, 5 g of Pheniramine was stirred and dissolved, and 2.9 g of maleic acid was added and stirred at room temperature, and the mixture was filtered, and dried under vacuum at 45 °C to obtain Pheniramine maleate 5.1 g.

Uses

Used medicinally as an antihistaminic (merck).

Drug Function and Efficacy

Not yet clear

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Naphthyl eye drops
Ingredients	This product is a compound preparation. Each milliliter contains 3 mg of pheniramine maleate and 0.25 mg of naphazoline hydrochloride. The excipients are: boric acid, borax, disodium edetate, glycerol, sodium hyaluronate, and chlorobutanol.
Indication	Patients taking monoamine oxidase inhibitors should avoid using this product together as it may cause severe hypertensive crisis.
Specifications	5ml: naphazoline hydrochloride 1.25mg and pheniramine maleate 15mg; 10ml: naphazoline hydrochloride 2.5mg and pheniramine maleate 30mg; 15ml: naphazoline hydrochloride 3.75mg and pheniramine maleate 45mg
Manufacturer	Shandong Bausch & Lomb Freda Pharmaceutical Co., Ltd.

Pheniramine maleate naphazoline hydrochloride eye drops
Specifications	15ml: pheniramine maleate 45mg, naphazoline hydrochloride 3.75mg

Pheniramine Maleate
Manufacturer	Shandong Bausch & Lomb Freda Pharmaceutical Co., Ltd.

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Registered Holders

KONGO CHEMICAL CO LTD

United States
Active
KESHAVA ORGANICS PVT LTD

India
Active
Guangzhou Greensyn Pharma Co., Ltd.

China
Active

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