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Lidocaine

Lidocaine structure

CAS No:
137-58-6
Formula:
C14H22N2O
Chemical Name:
Lidocaine
Synonyms:
Acetamide,2-(diethylamino)-N-(2,6-dimethylphenyl)-;2′,6′-Acetoxylidide,2-(diethylamino)-;2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide;α-Diethylamino-2,6-acetoxylidide;2-(Diethylamino)-2′,6′-acetoxylidide;Isicaine;Leostesin;Lidocaine;Lignocaine;Maricaine;Rucaina;Xycaine;Xylocaine;Xylocitin;Duncaine;Xylestesin;Anestacon;Solcain;Xylocain;Isicaina;Xilina;Xyline;Remicaine;Medicaine;Jetocaine;Lidoderm;Cuivasil;Dalcaine;Solarcaine;Lida-Mantle;NSC 40030;Lidocadren;Esracaine;Penles;LMX;ELA-Max;Aritmal;Trachisan;Linisol;Xylovet;Versatis;Xybrex;LidoPosterine;Lidocain;8059-42-5;8059-66-3;91484-71-8
Categories:
Active Pharmaceutical Ingredients > Anesthetic Agents

Description

Lidocaine, an amide local anesthetic, has anti-inflammatory properties in vitro and in vivo, possibly due to an attenuation of pro-inflammatory cytokines, intracellular adhesion molecule-1 (ICAM-1), and reduction of neutrophils influx.Target: Lidocaine is a common local anesthetic and antiarrhythmic drug. Lidocaine is used topically to relieve itching, burning and pain from skin inflammations, injected as a dental anesthetic or as a local anesthetic for minor surgery. Lidocaine, the firs

Lidocaine Basic Attributes

Molecular Weight：

234.33700

Exact Mass：

234.34

EC Number：

205-302-8

HScode：

2924299090

Characteristics

PSA：

32.34000

XLogP3：

2.65670

Appearance：

Solid

Density：

1.026g/cm3

Melting Point：

68.5 °C

Boiling Point：

159-160 °C @ Press: 2 Torr

Flash Point：

166ºC

Refractive Index：

1.512

Water Solubility：

Practically insoluble in water

Storage Conditions：

Store in a cool, dry place. Keep container closed when not in use.

Vapor Pressure：

4.28E-05mmHg at 25°C

Odor：

Characteristic odor

PKA：

8.01None

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

3249

wgk germany：

hazard class code：

R22

safety instructions：

S22-S26-S36

RTECS Number：

AN7525000

Marks：

Stability/Shelf Life：

Stable. Incompatible with strong oxidizing agents.

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

Lidocaine Use and Manufacturing

Medication.This product is an amide local anesthetic. It is widely used in surface anesthesia, infiltration anesthesia, conduction anesthesia and epidural anesthesia. Lidocaine hydrochloride oral LD50 to mice is 290mg/kg. Used as a local anesthetic

Computed Properties

Molecular Weight:234.34
XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:234.173213330
Monoisotopic Mass:234.173213330
Topological Polar Surface Area:32.3
Heavy Atom Count:17
Complexity:228
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

N-Methylaniline

Downstream Products

Acetone

Drug Function and Efficacy

Lidocaine is an amide local anesthetic that stabilizes nerve cell membranes and blocks nerve excitation and conduction by inhibiting the sodium ion channels of nerve cell membranes.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Diclofenac Sodium Lidocaine for Injection
Specifications	Each vial contains 75mg of diclofenac sodium and 20mg of lidocaine hydrochloride (calculated as lidocaine)
Manufacturer	Hainan Zhongyu Pharmaceutical Co., Ltd.

Lidocaine gel patch
Ingredients	The main ingredient of this product is lidocaine, chemical name: N-(2,6-dimethylphenyl)-2-(diethylamino)acetamide Chemical structure: Molecular formula: C14H22N2O Molecular weight: 234.34
Indication	Antiarrhythmic drugs: Patients taking class I antiarrhythmic drugs (such as tocainide, mexiletine) should use this product with caution because toxic effects may be additive or synergistic. Local anesthetics: When this product is used in combination with other drugs containing local anesthetic ingredients, the total absorption of all preparations should be considered.
Specifications	Each patch (14.0 cm x 10.0 cm) contains 14 grams of ointment and 700 mg of lidocaine.

Compound lidocaine cream
Ingredients	This product is a compound preparation, its components are: prilocaine and lidocaine, each gram of this product contains 25 mg of prilocaine and 25 mg of lidocaine.
Indication	This product may increase the formation of methemoglobin in patients who are receiving other drugs that can cause methemoglobinemia, such as sulfonamides. When using large doses of this product, patients who are receiving other local anesthetics or other drugs with similar molecular structures to local anesthetics should be considered to have systemic toxic effects, such as tocaine.
Specifications	Each gram contains 25 mg of prilocaine and 25 mg of lidocaine
Manufacturer	Tongfang Pharmaceutical Group Co., Ltd.

See More Related Drugs

Registered Holders

Jining Shenzhou Pharmaceutical Co., Ltd.

China
Active
APEX HEALTHCARE LTD

United States
Active
SWATI SPENTOSE PRIVATE LTD

United States
Active

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