 Home > Encyclopedia > 3,5,6,7,8,3′,4′-Heptamethoxyflavone

3,5,6,7,8,3′,4′-Heptamethoxyflavone

3,5,6,7,8,3′,4′-Heptamethoxyflavone structure

CAS No:
1178-24-1
Formula:
C22H24O9
Chemical Name:
3,5,6,7,8,3′,4′-Heptamethoxyflavone
Synonyms:
4H-1-Benzopyran-4-one,2-(3,4-dimethoxyphenyl)-3,5,6,7,8-pentamethoxy-;Flavone,3,3′,4′,5,6,7,8-heptamethoxy-;2-(3,4-Dimethoxyphenyl)-3,5,6,7,8-pentamethoxy-4H-1-benzopyran-4-one;3,5,6,7,8,3′,4′-Heptamethoxyflavone;3,3′,4′,5,6,7,8-Heptamethoxyflavone;3′,4′,3,5,6,7,8-Heptamethoxyflavone;NSC 618928;3-Methoxynobiletin;3,5,6,7,8,3′,4′-Heptamethphoxyflavone;2-(3,4-Dimethoxyphenyl)-3,5,6,7,8-pentamethoxychromen-4-one
Categories:
Biochemical Engineering > Plant Extracts

Description

3,5,6,7,8,3',4'-heptamethoxyflavone, a flavonoid in C. unshiu peels, exhibits anti-tumor-initiating effect and Anti-neuroinflammatory activity[1][2][3]. 3,5,6,7,8,3',4'-heptamethoxyflavone inhibits collagenase activity and increased type I procollagen content in HDFn cells[1]. 3,5,6,7,8,3',4'-heptamethoxyflavone induces brain-derived neurotrophic factor (BDNF) expression via cAMP/ERK/CREB signaling and reduces phosphodiesterase activity in C6 cells[4].

Solid

3-Methoxynobiletin is a member of flavonoids and an ether.

3,5,6,7,8,3′,4′-Heptamethoxyflavone Basic Attributes

Molecular Weight：

432.43

Exact Mass：

432.42

UNII：

288R4CAV1V

NSC Number：

618928

DSSTox ID：

DTXSID70151912

HScode：

2914509090

Characteristics

PSA：

90.9

XLogP3：

3.2

Appearance：

Solid

Density：

1.31±0.1 g/cm3(Predicted)

Melting Point：

129-131 °C

Boiling Point：

618.7±55.0 °C(Predicted)

Flash Point：

268.0±31.5 °C

Refractive Index：

1.576

Water Solubility：

35.1 mg/L @ 25 °C (est)

Drug Information

MeSH Entry Terms：

3,3',4',5,6,7,8-heptamethoxyflavone

3,5,6,7,8,3′,4′-Heptamethoxyflavone Use and Manufacturing

Methods of Manufacturing

Said compounds are, further more preferably, the following compounds: Compound 504:...5, 7, 3', 4'-tetra methoxyl-flavone;5, 7, 3', 4', 5'-penta methoxyl-flavanone;3, 5, 7, 8, 3', 4', 5', 6'-octa methoxyl-flavone;3, 5, 6, 7, 8, 3', 4', 5'-octa methoxyl-flavone;3, 5, 6, 7, 8, 3', 4'-hepta methoxyl-flavone;3, 5, 6, 7, 3', 4', 5'-hepta methoxyl-flavone;3, 5, 7, 8, 3', 4', 5'-hepta methoxyl-flavone;5, 6, 7, 8, 3', 4'-hexa methoxyl-flavone;...General procedure: 3, 5, 6, 7, 8, 4?-Hexamethoxyflavone (5): Me2SO4 (0.2 mL, 1 equiv.)was added dropwise to a stirred solution of 6, 8-dimethoxydiosmetin(100 mg) in acetone (20 mL) and K2CO3 (144 mg) at room temperaturefor 2 h. The mixture was filtered, and the filtrate was evaporated toafford a crude solid which was crystallised from petroleum ether/ethylacetate (3 : 1) to afford yellow crystals: 84 mg; 81%;General procedure: A flask was charged with a flavone (5 mmol) and Lawesson's reagent (2.5 mmol) under nitrogen atmosphere, after 5 min, 35 mL of dry methylbenzene was added by syringe and the mixture was stirred while being brought to reflux. The mixture was heated to 110' for 6h and then cooled to room temperature. The methylbenzene is removed and concentrated in vacuo. The residue was purified by column chromatography methods to obtain target products.

Use Classification：

Polyketides [PK] -> Flavonoids [PK12] -> Flavones and Flavonols [PK1211]

Computed Properties

Molecular Weight:432.4
XLogP3:3.2
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:8
Exact Mass:432.14203234
Monoisotopic Mass:432.14203234
Topological Polar Surface Area:90.9
Heavy Atom Count:31
Complexity:651
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 3,5,6,7,8,3′,4′-Heptamethoxyflavone

Cuicheng Biomedical Technology Contact Supplier

CN
1 YR

Business licensed Certified factory

Manufactory Supplier of Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5,Ginsenoside Rg5,Ginsenoside Rh2,Protopanaxatriol,Epmedin C,Icariin,Icaritin,Baohuoside I,Total Ginsenosides,Total Ginsenosides from Ginseng Stems And Leaves,Oridonin,Oleuropein,Curcumin,(20)-Ginsenoside Rg3,(20)-Protopanaxadiol

3,5,6,7,8,3',4'-Heptamethoxyflavone

Unit Price: $26038-27000 /G EXW

CAS No.: 1178-24-1

Grade: Industrial Grade

Content: 98%

Inquiry
Hubei CuiRan Biotechnology Co., Ltd Contact Supplier

CN
3 YRS

Business licensed Certified factory

Manufactory Supplier of Standard of traditional Chinese medicine reference,natural compounds,nature active compounds,pharmaceutical screening active compounds

3,3',4',5,6,7,8-heptamethoxyflavone

CAS No.: 1178-24-1

Content: 98%

Inquiry

Learn More Other Chemicals

25-Deoxyecdysone

22005-50-1
compoundk

160729-91-9
7-[4-[4-(2-bromophenyl)piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one

203395-84-0
Moscatilin Formula

108853-14-1
beta-sitosterol sulfate Formula

24815-93-8
Cocoa butter Formula

8002-31-1
(2β,3β,5β,22S)-22,25-Epoxy-2,3,14,20-tetrahydroxycholest-7-en-6-one Structure

26361-67-1
escin IIa Structure

158732-55-9
What is Carvacryl acetate

6380-28-5
What is 13,28-Epoxy-16β-hydroxyolean-11-en-3β-yl 6-deoxy-3-O-(β-D-glucopyranosyl)-β-D-galactopyranoside

64340-44-9

Hot Searches: iodate; flunarizine; red88.ag; phosphate aluminum; furfuryl alcohol; methanol molecular weight

Guide of 3,5,6,7,8,3′,4′-Heptamethoxyflavone

Description
Basic Attributes
Characteristics
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Learn More Other Chemicals

3,5,6,7,8,3′,4′-Heptamethoxyflavone

SDS

Request for Quotation



Feedback & Suggestions

Send Message

Thank you for your feedback. If you require further assistance, please contact us by email at info@echemi.com or call us at +86-532-55729510.