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Malathion

Malathion structure

CAS No:
121-75-5
Formula:
C10H19O6PS2
Chemical Name:
Malathion
Synonyms:
Butanedioic acid,2-[(dimethoxyphosphinothioyl)thio]-,1,4-diethyl ester;Succinic acid,mercapto-,diethyl ester,S-ester with O,O-dimethyl phosphorodithioate;Butanedioic acid,[(dimethoxyphosphinothioyl)thio]-,diethyl ester;SF 60;8059HC;ENT 17,034;American Cyanamid 4,049;S-[1,2-Bis(ethoxycarbonyl)ethyl] O,O-dimethyl phosphorodithioate;S-[1,2-Bis(ethoxycarbonyl)ethyl] O,O-dimethyl thiophosphate;Carbophos;Compound 4049;Fosfothion;Insecticide no. 4049;Karbofos;Malathion;Malathion LV Concentrate;Mercaptothion;Phosphothion;Ethiolacar;Fosfotion;Malamar 50;Oleophosphothion;Sadophos;Siptox I;Sadofos;Cythion;O,O-Dimethyl S-(1,2-dicarbethoxyethyl) dithiophosphate;Sumitox;Carbetox;Malathion E 50;S-[1,2-Bis(carbethoxy)ethyl] O,O-dimethyl dithiophosphate;[(Dimethoxyphosphinothioyl)thio]butanedioic acid diethyl ester;Diethyl mercaptosuccinate S-ester with O,O-dimethyl phosphorodithioate;Insecticide 4049;Carbofos;Malaspray;Prioderm;Zithiol;Ortho Malathion;Malatol;Fyfanon;Moscarda;TM 4049;Malafor;Etiol;Vetiol;Carbetovur;TAK (pesticide);Malasol;Extermathion;Forthion;Malathyl;Cimexan;Hilthion;IFO 13140;Malataf;TAK;Mavidan;Security;Malathyne;Malamar;Malathine;Maldison;Ovide;Organoderm;Suleo M;Derbac M;ENT 17034;NSC 6524;Malatol 500CE;Malathion ULV;Hi-Yield;Radotion P 5;Radotion;Gammaxine;Atrapa;Nassrlathion;Kunamala;Radotion E 50;Hymal;Malataf 57EC;Malapron;141263-96-9;11096-67-6;11130-60-2;12737-19-8;12767-62-3;75513-83-6
Categories:
Active Pharmaceutical Ingredients > Other Chemical Drugs

Description

Malathion is a clear amber liquid. It is sparingly soluble in water, but soluble in a majority of organic solvents. The US EPA grouped malathion under GUP. It is used as an insecticide as well as an acaricide for the control of pests. Malathion is used for the control of sucking insects and chewing insects on fruits and vegetables, and is an effective insecticide for the control of several household pests, such as housefl ies, cockroaches, mosquitos, aphids, animal ectoparasites, and human head

Malathion Basic Attributes

Molecular Weight：

330.36

Exact Mass：

330.36

EC Number：

204-497-7

HScode：

29309090

Characteristics

PSA：

128

XLogP3：

2.4

Appearance：

liquid

Density：

1.23 g/cm³ @ Temp: 25 °C

Melting Point：

2.9 °C

Boiling Point：

156-157 °C @ Press: 0.7 Torr

Flash Point：

-18 °C

Refractive Index：

nD25 1.4985

Water Solubility：

H2O: 0.0145 g/100 mL

Storage Conditions：

APPROX 4°C

Vapor Pressure：

7.95 at 25 °C (gas saturation method-GC, Kim et al., 1984)

Vapor Density：

Relative vapour density (air = 1): 11.4

Toxicity：

Oral-rat LD50: 290 mg/kg; Oral-Mouse LD50：190 mg/kg

Flammability characteristics：

Open flame is flammable; heat decomposes toxic phosphorus oxide and sulfur oxide gas

Explosive limit：

Above 100 deg C, decomposes rapidly and explosion may be induced.

Odor：

Skunk-like odor

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

UN 2783

hazard class code：

22-50/53-67-65-38-11-43

safety instructions：

2-24-60-61-62-46-37-16

RTECS Number：

WM8400000

Marks：

Xn;N,N,Xn,F

Storage features：

Treasury is ventilated at low temperature and dry; stored separately from oxidants and food additives

Stability/Shelf Life：

Stable. Incompatible with oxidizing agents, metals.

Precautionary statement(s)：

P261, P264, P270, P272, P273, P280, P301+P312, P302+P352, P321, P330, P333+P313, P363, P391, P501

Hazard Statements：

H302

Toxicity

Toxicity class：

highly toxic

Malathion Use and Manufacturing

Methods of Manufacturing

Esterification produces maleic acid diethyl ester from maleic acid (or anhydride) and ethanol under sulfuric acid catalysis. Benzene is used as a solvent, and ternary azeotropic dehydration with benzene, ethanol, and water is used to facilitate the esterification reaction. Synthesize O, O-dimethyl dithiophosphoric acid (see the preparation method of Dimethoate) and add diethyl maleate to get malathion. The ratio of O, O-dimethyl thiophosphoric acid and diethyl maleate is 1:1.15, the reaction temperature is 55 ≤70℃, and the reaction time is about 7h.

Uses

Insecticide.

Computed Properties

Molecular Weight:330.4
XLogP3:2.4
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:11
Exact Mass:330.03606767
Monoisotopic Mass:330.03606767
Topological Polar Surface Area:128
Heavy Atom Count:19
Complexity:341
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Maleic anhydride

Ethanol

Methanol

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High quality Malathion CAS NO.121-75-5

CAS No.: 121-75-5

Grade: Pharmaceutical Grade

Content: 99%

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