Propargite

350.47200

350.47

219-006-1

30M429ANKL

3082|2765

DTXSID4024276

Brownish-yellow, oily viscous liquid (tech.)|Light to dark brown viscous liquid

2920909014

63.97000

4.78490

Propargite is a dark colored liquid. It is a wettable powder or water emulsifiable liquid. It can cause illness by inhalation, skin absorption and/or ingestion. The primary hazard is the threat to the environment. Immediate steps should be taken to limit its spread to the environment. Since it is a liquid it can easily penetrate the soil and contaminate groundwater and nearby streams. It is used as a pesticide. Practically insoluble in water (10.5 mg/L). Used as an acaricide.

1.17 g/cm3

<25 °C

450.7ºC at 760 mmHg

226.4ºC

1.56

In water, 0.215 mg/L at 25 deg C

2-8ºC

6.9E-08mmHg at 25°C

LD50 in male, female rats (mg/kg): 1480, 1480 orally; 250, 680 dermally (Gaines); LC50 in rainbow trout, bluegill sunfish (ppb): >100, 31 (Stone)

Henry's Law constant = 6.4X10-7 atm cu m/mol at 25 °C (est)

Hydroxyl radical reaction rate constant = 6.0X10-11 cu cm/molec-sec at 25 °C (est)|DARK AMBER, VISCOUS OIL; DENSITY: 1.085-1.115 @ 25 °C; PRACTICALLY INSOL IN WATER; SOL IN MOST ORG SOLVENTS. /TECHNICAL PRODUCT/

Practically insoluble in water (10.5 mg/L). Slowly reacts with water to form sulfur dioxide and alcohols; reaction is more rapid under basic or acidic conditions.

Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters

PROPARGITE is a sulfite ester. As an ester, it will hydrolyze to form sulfur dioxide and alcohols; reaction is more rapid under basic conditions. It may react exothermically with acids to generate alcohols. Heat will be generated by interaction with basic or caustic solutions. Flammable hydrogen is generated by mixing with alkali metals and hydrides.

III

9

UN 2810

3

R23; R38; R40; R41; R50/53

S26-S36/37/39-S45-S60-S61

WT2900000

T

Containers may rupture under fire conditions.

P261-P273-P280-P305 + P351 + P338-P311-P501

H315-H318-H331-H351-H410

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.|This pesticide is toxic to fish. Do not discharge effluent into lakes, streams, ponds, estuaries, oceans, or public waters unless in accordance with the requirements of a National Pollutant Discharge Elimination System (NPDES) permit and the permitting authority has been notified in writing prior to discharge.|Runoff from treated areas may be hazardous to aquatic organisms in neighboring areas. Do not apply by ground application equipment within 50 feet of surface waters or by aerial application equipment within 75 feet of surface water. ... Do not contaminate water when disposing of equipment wash water.

USEPA/Office of Pesticide Programs; Reregistration Eligibility Decision Document - Propargite (September 2001). The RED summarizes the risk assessment conclusions and outlines any risk reduction measures necessary for the pesticide to continue to be registered in the U.S.[Available from, as of June 13, 2007: http://www.epa.gov/pesticides/reregistration/status.htm]|USEPA/Office of Pesticide Programs; Reregistration Eligibility Decision Document - Propargite. 147 p. Case No. 0243 Effective: September 28, 2001 Amended: December 15, 2005. This document contains a generic and/or a product-specific Data Call-In(s) (DCI) that outline(s) further data requirements for this chemical. ... This RED also contains labeling requirements for propargite products.[Available from, as of June 5, 2007: http://www.epa.gov/pesticides/reregistration/status.htm]

Special Hazards of Combustion Products: Irritating fumes of sulfur oxides are produced. Behavior in Fire: Containers may rupture in fire conditions and may decompose to corrosive SO 2 . (USCG, 1999)|Teratogens, Flammable - 3rd degree

|Danger|H315: Causes skin irritation [Warning Skin corrosion/irritation]|P201, P202, P261, P264, P271, P273, P280, P281, P302+P352, P304+P340, P305+P351+P338, P308+P313, P310, P311, P321, P332+P313, P362, P391, P403+P233, P405, and P501|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|Aggregated GHS information provided by 171 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H227: Combustible liquid [Warning Flammable liquids]|P210, P260, P261, P264, P270, P272, P280, P301+P312, P302+P352, P305+P351+P338, P310, P312, P314, P321, P322, P330, P332+P313, P333+P313, P362, P363, P370+P378, P403+P235, and P501|P201, P202, P210, P260, P261, P264, P270, P271, P273, P280, P281, P301+P312, P302+P352, P304+P340, P305+P351+P338, P308+P313, P311, P312, P314, P321, P322, P330, P332+P313, P337+P313, P362, P363, P370+P378, P391, P403+P233, P403+P235, P405, and P501

Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]: SMALL FIRE: Dry chemical, CO2, water spray or regular foam. LARGE FIRE: Water spray, fog or regular foam. Do not scatter spilled material with high-pressure water streams. Move containers from fire area if you can do it without risk. Dike fire-control water for later disposal. FIRE INVOLVING TANKS: Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. (ERG, 2016)

Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]: Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent dust cloud. Avoid inhalation of asbestos dust. SMALL DRY SPILL: With clean shovel, place material into clean, dry container and cover loosely; move containers from spill area. SMALL SPILL: Pick up with sand or other non-combustible absorbent material and place into containers for later disposal. LARGE SPILL: Dike far ahead of liquid spill for later disposal. Cover powder spill with plastic sheet or tarp to minimize spreading. Prevent entry into waterways, sewers, basements or confined areas. (ERG, 2016)

Rubber gloves and boots, safety goggles or face mask, hooded suit and either a respirator with approved canister or a self-contained breathing apparatus. (USCG, 1999)|Engineering Controls ... for liquid products. Mixers and loaders supporting aerial applications to corn and cotton must use a closed system that meets the requirements listed in the Worker Protection Standard (WPS) for agricultural pesticides [40 CFR 170.240(d)(4)], and must: -- wear the personal protective equipment required above for mixers/loaders, -- wear protective eyewear if the system operates under pressure, and -- be provided and have immediately available for use in an emergency, such as a broken package, spill, or equipment breakdown: coveralls, and chemical-resistant footwear . Pilots must use an enclosed cockpit in a manner that meets the requirements listed in the Worker Protection Standard (WPS) for agricultural pesticides [40 CFR 170.240(d)(6)]; Applicators using airblast spray equipment must use an enclosed cab that meets the definition in the Worker Protection Standard for Agricultural Pesticides [40 CFR 170.240(d)(5)] for dermal protection. In addition, such applicators must: -- wear the personal protective equipment required above for applicators, -- be provided and must have immediately available for use in an emergency when they must exit the cab in the treated area: coveralls, chemical resistant gloves, chemical-resistant footwear, and chemical-resistant headgear, if overhead exposure, -- take off any PPE that was worn in the treated area before reentering the cab, and -- store all such PPE in a chemical-resistant container, such as a plastic bag, to prevent contamination of the inside of the cab. When other applicators use enclosed cabs in a manner that meets the requirements listed in the Worker Protection Standard (WPS) for agricultural pesticides (40 CFR 170.240(d)(4-6), the handler PPE requirements may be reduced or modified as specified in the WPS.|Engineering Controls ... for Wettable Powders in Water Soluble Packaging. All WP product must be packaged in Water Soluble Packaging (WSP) to be eligible for reregistration. Water-soluble packets when used correctly qualify as a closed mixing/loading system under the Worker Protection Standard for Agricultural Pesticides [40 CFR 170.240(d)(4)]. Mixers and loaders using water-soluble packets must : -- wear the personal protective equipment required above for mixers/ loaders, and -- be provided and must have it immediately available for use in an emergency, such as a broken package, spill, or equipment breakdown: coveralls, chemical-resistant footwear, and a NIOSH approved respirator with an organic vapor removing cartridge with a prefilter approved for pesticides (MSHA/NIOSH approval number prefix TC-23C), or a canister approved for pesticides (MSHA/NIOSH approval number prefix TC-14G), or an organic vapor cartridge or canister with any N, R, P or HE prefilter, and -Chemical-resistant headgear, if overhead exposure. Pilots must use an enclosed cockpit in a manner that meets the requirements listed in the Worker Protection Standard (WPS) for agricultural pesticides [40 CFR 170.240(d)(6)]; Applicators using airblast spray equipment must use an enclosed cab that meets the definition in the Worker Protection Standard for Agricultural Pesticides [40 CFR 170.240(d)(5)] for dermal protection. In addition, such applicators must: -- wear the personal protective equipment required above for applicators, -- be provided and must have immediately available for use in an emergency when they must exit the cab in the treated area: coveralls, chemical resistant gloves, chemical-resistant footwear, and chemical-resistant headgear, if overhead exposure, -- take off any PPE that was worn in the treated area before reentering the cab, and -- store all such PPE in a chemical-resistant container, such as a plastic bag, to prevent contamination of the inside of the cab." When other applicators use enclosed cabs in a manner that meets the requirements listed in the Worker Protection Standard (WPS) for agricultural pesticides (40 CFR 170.240(d)(4-6), the handler PPE requirements may be reduced or modified as specified in the WPS.|PPE Requirements Established ...for Wettable Powder product formulations (must be packaged in Water Soluble Packaging (WSP) to be eligible for reregistration). Mixers, loaders, applicators and other handlers must wear: Long-sleeved shirt and long pants, Shoes plus socks, Chemical-resistant gloves (except for flaggers and applicators using closed cabs), Chemical-resistant apron for mixers and loaders.|PPE Requirements ... for liquid products. Mixers, loaders, applicators and other handlers must wear: Long-sleeved shirt and long pants, Shoes plus socks, Chemical-resistant gloves (except for flaggers and applicators using closed cabs), Chemical-resistant apron for mixers and loaders and persons exposed to the concentrate.|PPE required for early entry to treated areas that is permitted under the Worker Protection Standard and that involves contact with anything that has been treated, such as plants, soil, or water, is: -- coveralls over long-sleeved shirt and long pants, -- chemical-resistant gloves made of any waterproof material, -- chemical-resistant footwear plus socks, and -- protective eyewear.

Follow manufacturer's instructions for cleaning/maintaining PPE. If no such instructions for washables exist, use detergent and hot water. Keep and wash PPE separately from other laundry.|Users should wash hands before eating, drinking, chewing gum, using tobacco, or using the toilet. Users should remove clothing/PPE immediately if pesticide gets inside. Then wash thoroughly and put on clean clothing. Users should remove PPE immediately after handling this product. Wash the outside of gloves before removing. As soon as possible, wash thoroughly and change into clean clothing.|Notify workers of the application /of this pesticide/ by warning them orally and by posting warning signs at entrances to treated area.|Do not apply this product in a way that will contact workers or other persons, either directly or through drift. Only protected handlers may be in the area during application.|For more Preventive Measures (Complete) data for PROPARGITE (6 total), please visit the HSDB record page.

In California, a number of complaints of dermatitis and eye irritation caused by propargite led to an investigation.|... The incident data contain cases showing propargite poses skin illness and eye irritation concerns for handlers and post-application workers.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 10 lb or 4.54 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

The concn of propargite measured in water which was used to rinse out the tanks of airplanes which sprayed the pesticide were 1,195, 89.0, and 4.13 mg/L for water from the first, second, and third washes, respectively(1). The initial tank concn was 15,385 mg/L(1). The concn of propargite in water used to wash off the exterior of the airplane was 0.70 mg/L(1). It was recommended that the rinse waters themselves should be sprayed onto the treated fields as a means of disposal(1). Propargite was found in seed cotton and cotton gin wastes collected in 1977 from the San Joaquin Valley at average concn of 3.20 and 3.94 ppm in the whole waste and in the separated fines, respectively(2). Propargite was detected at concn ranging from 120 to 320 ng/cu m (227 ng/cu m avg) in the air adjacent to the cotton gin waste screening operations(2). Propargite was not detected (detection limit 10 ng/cu m) in the air adjacent to the cotton gin waste composting operations(2).

URBAN/SUBURBAN: Propargite was detected in 3 out of 22 samples of urban air (mean concn 0.014 ug/cu m) in California(1).|RURAL/REMOTE: Propargite was detected in 67 out of 152 samples of rural air (mean concn 0.046 ug/cu m) in California(1).

LD50 Rabbit acute dermal >2000 mg/kg|LD50 Rat (female) acute oral 2947 mg/kg|LD50 Rat (male) acute oral 2639 mg/kg|LD50 Rat (male and female) acute oral 2800 mg/kg|For more Non-Human Toxicity Values (Complete) data for PROPARGITE (8 total), please visit the HSDB record page.

/OTHER TERRESTRIAL SPECIES/ The action on the honeybees of the ... acaricides hexythiazox and propargite was investigated by ingestion and indirect contact in laboratory tests. The results of the trials revealed that ... the heterocyclic carcoxamide hexyhiazox and the organic sulfite propargite were not toxic. ...

Propargite's production may result in its release to the environment through various waste streams; it's use as a miticide and acaricide(1) will result in its direct release to the environment(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), Koc values of 2,963-57,966 measured in soil(2), indicate that propargite is expected to have slight to no mobility in soil(SRC). Volatilization of propargite from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 6.4X10-7 atm-cu m/mole(SRC), derived from its vapor pressure of 3X10-7 mm Hg(3) and water solubility of 0.215 mg/L(3). Volatilization from dry soil surfaces is not expected(SRC) based on the vapor pressure of this compound(3). The time for 50% dissipation (DT50) of propargite in soil samples (pH 6-6.9, 1.0-2.55% organic carbon) under aerobic conditions was reported as 50-67 days(3). Hydrolysis in moist soils may also be an important fate process since propagite hydrolyzes quickly under alkaline conditions(2).|AQUATIC FATE: Based on a classification scheme(1), Koc values of 2,963-57,966 measured in soil(2), indicate that propargite is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected to be an important environmental fate process(3) based upon an estimated Henry's Law constant of 6.4X10-7 atm-cu m/mole(SRC), derived from its vapor pressure of 3X10-7 mm Hg(4) and water solubility of 0.215 mg/L(4). According to a classification scheme(5), an estimated BCF value of 4890 from a log Kow of 5.7(4) and regression derived equation(6), suggests the potential for bioconcentration in aquatic organisms is very high(SRC). The hydrolysis half-life of propargite at pH 5, 7, and 9 is 120 days, 75 days, and 2.2 days, respectively(2). The time for 50% dissipation(DT50) of propargite in an aqueous photolysis experiment was 6 days and the biodegradation DT50 was 18.3-22.5 days in a sediment/water system(4).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), propargite, which has a vapor pressure of 3X10-7 mm Hg at 25 °C(1) is expected to exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase propargite is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals and ozone molecules(SRC). The half-life for this reaction in air is estimated to be 6 hours for hydroxyl radicals and 382 days for ozone(SRC), calculated from their respective rate constants of 6.0X10-11 cu cm/molecule-sec and 3X10-20 cu cm/molecule-sec at and 25 °C(SRC) that were derived using a structure estimation method(3). Particulate-phase propargite may be removed from the air by wet or dry deposition(SRC). Propargite may undergo direct photolysis in the environment based upon an aqueous photolysis 50% dissipation time (DT50) of 6 days following exposure to sunlight(2).

The rate constant for the vapor-phase reaction of propargite with photochemically-produced hydroxyl radicals has been estimated as 6.0X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 6 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). The rate constant for the vapor-phase reaction of propargite with ozone has been estimated as 3X10-20 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(1). This corresponds to an atmospheric half-life of about 382 days at an atmospheric concentration of 7X10+11 ozone molecules per cu cm(2). Direct photolysis in air is possible based upon an aqueous photolysis 50% dissipation time (DT50) of 6 days following exposure to sunlight(3). The hydrolysis half-life of propargite is 120 days, 75 days, and 2.2 days at pH 5, 7, and 9, respectively(4).

An estimated BCF of 4890 was calculated in fish for propargite(SRC), using a log Kow of 5.7(1) and a regression-derived equation(2) . According to a classification scheme(3), this BCF value suggests the potential for bioconcentration in aquatic organisms is very high(SRC).

3.98e+03 L/kg|The Koc of propargite was reported to range from 2,963-57,966 in an unspecified number of soils(1). According to a classification scheme(2), this range of Koc values indicates that propargite is expected to have slight to no mobility in soil(SRC).

The Henry's Law constant for propargite is estimated as 6.4X10-7 atm-cu m/mole(SRC) derived from its vapor pressure, 3X10-7 mm Hg(1), and water solubility, 0.215 mg/L(1). This Henry's Law constant indicates that propargite is expected to be essentially nonvolatile from water and moist soil surfaces(2). Propargite is not expected to volatilize from dry soil surfaces based on its vapor pressure(1).

GROUNDWATER/DRINKING WATER: Propargite was detected, but not quantified, in 2 out of an unspecified number of samples of groundwater in California (detection limit not specified)(1). Propargite was detected in 0.1% of 1,012 wells and 22 springs tested across the US at a max concn 0.009 ug/L(2).|SURFACE WATER: Propargite was detected in 22 out of 142 water samples (max concn 20 ug/L) taken from 4 sites in the San Joaquin River Basin(1). Propargite was detected in 3 out of 98 water samples (max concn 0.04 ug/L) collected from the Yakima River Basin, Washington during May 1999-January 2000 sampling(2). Propargite was detected in 0.5% of samples tested in 8 US urban streams at a max concn of 0.015 ug/L(3).

Propargite residues on Valencia oranges initially decreased rapidly due to weathering processes but approximately one-third (between 2 and 3 ppm) of the original residues remained after approximately 130 days(1). The remaining residues apparently had migrated into the fruit rind(1). Propargite was identified, not quantified, in the 2000, 2001, 2002, and 2003 FDA Market Basket Survey of domestic and imported food items(2). Propargite was detected in 6 out of 86 apples tested during the 1995-2000 food monitoring study of domestic and imported foods in Japan(3). Propargite was detected in 81 out of 769 domestic apples (max concn 1.6 ppm), and 94 out of 1,062 imported apples (max concn 2.6 ppm)in a US FDA pesticide monitoring study(4).

Occupational exposure to propargite may occur through inhalation of dust and dermal contact with this compound at workplaces where propargite is produced or used. Exposure to the general public may occur through inhalation, ingestion of drinking water derived from contaminated groundwater, or from consumption of food containing propargite. (SRC)

When 50-mg samples of bulb mites, Rhizoglyphus echinopus (Fumouze and Robin), were placed for 1 hr in glass vials coated with 0.53 mug of radiocarbon-labeled propargite, about 12% (1.27 ug/g) of the acaricide was transferred to the mites. Mites treated with propargite were kept in holding vials and the extent of metabolism was evaluated after 6, 12, 24, and 48 hr. Internal levels of radiocarbon ranged from 14.8 to 17.4% of the dose and were divided about equally between the mite extrat and mite residue fractions. Levels of propargite in the internal extract decreased from 5.9 at 6 hr to 2.5 at 48 hr when expressed as percentage of total recovered radiocarbon and from 61.5 at 6 hr to 29.8 at 48 hr when expressed as relative percentage of radiocarbon in the internal extract. Thus, propargite was degraded slowly by the mites. The metabolites 4-tert-butylphenol and 2-(4-tert-butylphenoxy) cyclohexanol (glycol ether) were present at low levels (< 0.5%). Propargite was degraded in vitro by bulb mite homogenates with the 12,000 pernatant being about four times more active than the corresponding pellet. Exogenous NADPH and glutathione greatly enhanced propargite degradation by the supernatant fraction. However, not all of the degradation in the presence of glutathione was enzymatic; about 15% of the propargite was converted to 4-tert-butylphenol when the acaricide was incubated with cofactor in buffer in the absence of the mite supernatant. In vitro propargite degradation products consisted mainly of unindentified polar metabolites, but low levels of 4-tert-butylphenol and glyol ether also were present.

INHALATION: Irritation of mucous membranes. EYES: Irritation, may be severe. SKIN: Irritation. (USCG, 1999)

Call a physician. INHALATION: Move to fresh air. EYES: Flush with water. SKIN: Wash. (USCG, 1999)

Gastrointestinal decontamination. If large amounts of propargite have been ingested and the patient is seen within an hour, consider gastrointestinal decontamination. For small ingestions, consider oral administration of activated charcoal and sorbitol. /Other Insecticides: Propargite; Haloaromatic Substituted Ureas/|Skin decontamination. Wash skin with soap and water... . Eye contamination should be removed by prolonged flushing of the eye with copious amounts of clean water or saline. If irritation persists, obtain specialized medical treatment. Sensitization reactions may require steroid therapy. /Other Insecticides: Propargite; Haloaromatic Substituted Ureas/|Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/|Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poisons A and B/

/EPIDEMIOLOGY STUDIES/ ... Population-based childhood cancer incidence rates throughout California /were analyzed/ in relation to agricultural pesticide use. During 1988-1994, a total of 7,143 cases of invasive cancer were diagnosed among children under 15 years of age in California. Building on the availability of high-quality population-based cancer incidence information from the California Cancer Registry, population data from the U.S. Census, and uniquely comprehensive agricultural pesticide use information from California's Department of Pesticide Regulation, /the authors/ used a geographic information system to assign summary population, exposure, and outcome attributes at the block group level. /They/ used Poisson regression to estimate rate ratios (RRs) by pesticide use density adjusted for race/ethnicity, age, and sex for all types of childhood cancer combined and separately for the leukemias and central nervous system cancers. ...Generally ... no association /was found/ between pesticide use density and childhood cancer incidence rates. The RR for all cancers was 0.95 [95% confidence interval (CI), 0.80-1.13] for block groups in the 90th percentile and above for use of pesticides classified as probable carcinogens, compared to the block groups with use of < 1 lb/sq mi. The RRs were similar for leukemia and central nervous system cancers. Childhood leukemia rates were significantly elevated (RR = 1.48; 95% CI, 1.03-2.13) in block groups with the highest use of propargite, although ... no dose-response trend with increasing exposure categories /was seen/. Results were unchanged by further adjustment for socioeconomic status and urbanization.|/EPIDEMIOLOGY STUDIES/ Previous studies have indicated that farm workers may be at increased risk of gastric cancer. Meta-analyses, ecological, case-control, and cohort studies suggest that some aspects of the agricultural environment may be implicated in the elevated risk. Hispanic farm workers in California are exposed to a multitude of potentially toxic substances in the work site, including excessive sunlight, fertilizers, diesel fumes, and pesticides. A previous analysis of a cohort of California farm workers who had been members of a farm labor union, the United Farm Workers of America (UFW) found a proportionate cancer incidence ratio for stomach cancer of 1.69 when using the California Hispanic population as the standard. The aim of the current study was to further evaluate associations between gastric cancer and the types of crops and commodities UFW members cultivate and the associated pesticide use as recorded by the California Department of Pesticide Regulation (DPR). /The authors/ conducted a nested case-control study of gastric cancer embedded in the UFW cohort and identified 100 cases of newly diagnosed gastric cancer between 1988 and 2003. /They/ identified 210 control participants matched on age, gender, ethnicity, and who were known to be alive and resident in California up to the date of the cases' diagnosis. Both stratified analyses and unconditional logistic regression were used to calculate adjusted odds ratios (OR) and 95% confidence intervals (95% CI). Work in the citrus industry was associated with increased gastric cancer (OR=2.88; 95% CI=1.02-8.12) although no other specific crops or commodities were associated with this disease. Working in areas with high use of the phenoxyacetic acid herbicide 2,4-D was associated with gastric cancer (OR=1.85; 95% CI=1.05-3.25); use of the organochlorine insecticide chlordane was also associated with the disease (OR=2.96; 95% CI=1.48-5.94). Gastric cancer was associated with use of the acaricide propargite and the herbicide triflurin (OR=2.86; 95% CI=1.56-5.23 and 1.69, 95% CI=0.99-2.89, respectively). Gastric cancer in California Hispanic farm workers is associated with work in the citrus fruit industry and among those who work in fields treated with 2,4-D, chlordane, propargite, and trifluin...|/SURVEILLANCE/ ... The four sources of information are OPP's Incident Data System (IDS), American Association of Poison Control Centers (PCC), California Department of Pesticide Regulation (CDPR), and the National Pesticides Telecommunication Network CDPR and OPP data tend to provide the most insight into propargite's association with human health incidents. ... The incident data contain cases showing propargite poses skin illness and eye irritation concerns for handlers and post-application workers. From CDPR data, field residue exposure was associated with the majority (66%) of the exposure cases in California. A large proportion of cases resulted from field reentry and worker activities involving extensive contact with treated foliage such as turning cane for grapes and harvesting citrus. Applicators and other handlers accounted for the bulk of the balance (28%). These data illustrate that human incidents have historically occurred mostly among workers and handlers. Propargite usually effects the skin in human exposure cases. Of the confirmed propargite cases reported to the CDPR between 1982 and 1996, 79% of the individuals developed skin illnesses as a result of exposure (528 of 671 persons). Data covering the years 1982-1989 found that propargite was the leading cause of skin-related injuries among all pesticides in California. For the years 1990-1994, propargite dropped to seventh place among pesticides. The drop in the frequency of illnesses in the early 1990's is apparently attributable to increasing restricted entry intervals (REI), which were put into place in 1989. Depending on the crop, REIs were extended from 2-7 days to 14-42 days....|/SURVEILLANCE/ In California, a number of complaints of dermatitis & eye irritation caused by propargite led to an investigation. In 1974 there were 36 recorded complaints assoc with the application of 358,477 kg of the cmpd on 179,160 ha. During the investigation in 1975, many complaints that had not been officially reported were found by questioning workers. Most complaints were assoc with single water wettable powder, which was very dusty, & most of the difficulty was assoc with mixing & loading. ... the offending formulation was withdrawn from sale in california & a newly developed wettable powder with negligible dustiness was substituted.|/SURVEILLANCE/ An outbreak of dermatitis cases among 198 orange pickers employed by a Tulare County, California, packinghouse was investigated. Dermatitis was contracted by 114 (58%) of the 198 workers exposed when Omite-CR-treated fields were harvested. The dermatitis occurred predominantly in the exposed areas of the neck and chest. A dose-response association with dermatitis was suggested for Omite-CR (Propargite) exposure, but not for Carzol, Omite-CR + Carzol, or other pesticides. Because no violations of pesticide preharvest intervals or application rates were found, it appears that residue degradation was not given adequate consideration in the registration of Omite-CR, thus compromising the safety of the worker.

2-(4-tert-butylphenoxy)cyclohexyl-2-propynyl sulfite

Consumption Patterns:|/On/ Alfalfa, 8.9%; Almonds, 14.8%; Beans, 4.9%; Corn, 22.9%; Cotton, 40.6% (1984) /California use, calculated from table/

OMITE - 30W Active Ingredient 32.00% Propargite|OMITE-57E Active Ingredient 57.00% Propargite|OMITE-6E Active Ingredient 69.20% Propargite|OMITE TECHNICAL Active Ingredient 90.60% Propargite|For more Formulations/Preparations (Complete) data for PROPARGITE (11 total), please visit the HSDB record page.

INTRODUCED IN 1964 BY UNIROYAL INC AS EXPTL ACARICIDE. US PATENT 3,272,854 & 3,311,534.|Restricted Use Pesticide Due to acute skin and eye effect. For retail sale to and use only by Certified Applicators, or persons under their supervision, and only for those uses covered by the Certified Applicator's certification.|Formulation Types Registered: Propargite is formulated as an emulsifiable concentrate liquid and as a wettable powder. Application Methods and Equipment Aerial (spray) Equipment: Foliar applications to fruit/nut trees, field crops (e.g., alfalfa, sorghum, corn), cotton, vegetable crops, specialty crops (e.g., Christmas trees, mint, peanuts), roots and tuber vegetable (e.g., carrot, sugar beet). Chemigation Equipment: Roots and vegetable (e.g., potatoes) and field crops. Groundboom Equipment: Fruit/nut orchard floors, field crops, cotton, and vegetable crops. Airblast Equipment: Fruit/nut/ornamental tree foliage. High Pressure Handwand Equipment: Non-bearing nursery stock. Application Rates and Frequency: 0.5 to 4.8 lbs active ingredient/acre; 2 to 3 times per year.

PRODUCT ANALYSIS IS BY INFRARED SPECTROSCOPY IN CARBON DISULFIDE SOLN @ 3.03 MICRONS.|GAS LIQUID CHROMATOGRAPHY METHOD. DETECTION LIMIT 0.1 PPM.|Method: USGS-NWQL O-1126-95; Procedure: gas chromatography/mass spectrometry; Analyte: propargite; Matrix: natural-water; Detection Limit: 0.006 ug/L.

Agrochemicals -> Acaricides|Fire Hazards -> Teratogens, Flammable - 3rd degree