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Rifamycin sodium

Rifamycin sodium structure

CAS No:
14897-39-3
Formula:
C37H47NO12.Na
Chemical Name:
Rifamycin sodium
Synonyms:
Rifamycin,sodium salt (1:1);2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,11(2H)-dione,5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-,21-acetate,sodium salt;Rifamycin,monosodium salt;2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan,rifamycin deriv.;Rifamycin SV sodium salt;Rifamycin SV sodium;Rifamycin sodium;Monosodium rifamycin SV;Rifamycin sodium salt;Tuborin;NSC 146718;CB 01-11;137360-32-8;15105-92-7;412909-18-3
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Rifamycin sodium (Rifamycin SV monosodium) belongs to the family of ansamycin antibiotics and has been isolated from the fermentation of A. mediterranei or its mutants. Rifamycin sodium displays a broad spectrum of antibiotic activity against Gram-positive and, to a lesser extent, Gram-negative bacteria[1].

Rifamycin Sodium is a sodium salt of rifamycin, an antibiotic produced by Streptomyces mediterranei which is used to treat mycobacterium infections.

Rifamycin sodium Basic Attributes

Molecular Weight：

719.75

Exact Mass：

719.291748

EC Number：

238-965-7

UNII：

32086GS35Z

DSSTox ID：

DTXSID0040208

NCI Thesaurus Code：

C95605

HScode：

2941903000

Characteristics

PSA：

204

XLogP3：

5.18780

Appearance：

COA

Density：

1.35g/cm3

Melting Point：

>215°C (dec.)

Boiling Point：

862.1ºC at 760mmHg

Flash Point：

475.2ºC

Water Solubility：

soluble in water, alcohol and dimethyl sulfoxide.ethanol: soluble 50mg/mL

Storage Conditions：

-20°C Freezer

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

safety instructions：

22-24/25

RTECS Number：

KD1922500

Marks：

GHS Classification：

|Warning|H315 (50%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Rifamycin sodium Use and Manufacturing

Methods of Manufacturing

The rifamycin S sodium obtained by fermentation is reduced with vitamin C, and the product is obtained by separation operation.

Uses

Semi-synthetic antibiotic derived from Rifamycin S. Antibacterial. Potency >900 units (dry basis).

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:719.7
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:3
Exact Mass:719.29177018
Monoisotopic Mass:719.29177018
Topological Polar Surface Area:204
Heavy Atom Count:51
Complexity:1340
Defined Atom Stereocenter Count:9
Defined Bond Stereocenter Count:3
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

This product is a broad-spectrum antibacterial drug in the semi-synthetic rifamycin class. Its mechanism of action is to inhibit the activity of ribonucleic acid polymerase in bacteria, thereby affecting the synthesis of ribonucleic acid and protein metabolism, resulting in the cessation of bacterial growth and reproduction to achieve a bactericidal effect. The sensitive bacteria of this product include: Staphylococcus aureus (including penicillin-resistant and neomycin-resistant strains), Mycobacterium tuberculosis, Streptococcus pyogenes, Pneumococcus, Gonorrhea, Escherichia coli, Meningococcus, Haemophilus influenzae, Legionella, etc.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Rifamycin Sodium Injection
Ingredients	Rifamycin sodium.
Indication	Not yet clear.
Specifications	2ml:0.125g (125,000 units)
Manufacturer	Chengdu First Pharmaceutical Co., Ltd.

Rifamycin Sodium Injection
Ingredients	Rifamycin sodium.
Indication	Not yet clear.
Specifications	5ml:0.25g

Rifamycin Sodium
Manufacturer	Kaifeng Pharmaceutical (GROUP) Co., Ltd.

See More Related Drugs

Registered Holders

Shanxi Zhongbao Pharmaceutical Co., Ltd.

China
Active
Kaifeng Pharmaceutical (GROUP) Co., Ltd.

China
Active
Fujian Mindong Rejuenation Pharmaceutical Co.,Ltd.

China
Active

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