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Tulathromycin

Tulathromycin structure

CAS No:
217500-96-4
Formula:
C41H79N3O12
Chemical Name:
Tulathromycin
Synonyms:
1-Oxa-6-azacyclopentadecan-15-one,13-[[2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(propylamino)methyl]-α-L-ribo-hexopyranosyl]oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-,(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-;(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[[2,6-Dideoxy-3-C-methyl-3-O-methyl-4-C-[(propylamino)methyl]-α-L-ribo-hexopyranosyl]oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one;CP 472295;Tulathromycin A;Draxxin;Tulathromycin;Tulissin;Tulaven;Lydaxx;Increxxa;Tulinovet
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Tulathromycin A is a macrolide antibiotic.IC50 Value: 1 microg/ml (MIC90 for Pasteurella multocida) [2]Target: Antibacterialin vitro: Two highly pathogenic strains of M. bovis (with minimum inhibitory concentration values for tulathromycin of 1 and >64 microg/ml) were inoculated into 145 calves. Four days after inoculation, calves with clinical BRD were treated subcutaneously with saline or tulathromycin (2.5 mg/kg). Compared with saline, BRD-related withdrawals, peak rectal temperatures

Tulathromycin A is an aminoglycoside.|Tulathromycin is a macrolide antibiotic used to treat bovine respiratory disease in cattle and swine respiratory disease in pigs. It is marketed by Pfizer Inc. under the tradename Draxxin.

Tulathromycin Basic Attributes

Molecular Weight：

806.084

Exact Mass：

806.08

EC Number：

1806241-263-5

UNII：

897A3KN7AP

DSSTox ID：

DTXSID60274184

ATC Code：

QJ01FA94

Characteristics

PSA：

201

XLogP3：

3.8

Density：

1.2±0.1 g/cm3

Boiling Point：

853.8±65.0°C at 760 mmHg

Flash Point：

470.2±34.3 °C

Refractive Index：

1.536

Collision Cross Section：

286.4 Å² [M+H]+ [CCS Type: TW]

Safety Information

Precautionary statement(s)：

P261, P264, P272, P273, P280, P302+P352, P305+P351+P338, P321, P333+P313, P337+P313, P363, P501

Hazard Statements：

H317

GHS Classification：

|Danger|H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]|P201, P202, P260, P261, P264, P270, P272, P273, P280, P281, P302+P352, P305+P351+P338, P308+P313, P310, P314, P321, P333+P313, P337+P313, P363, P391, P405, and P501|Aggregated GHS information provided by 106 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

Drug Indication：

Cattle: Treatment and metaphylaxis of bovine respiratory disease (BRD) associated with Mannheimia haemolytica, Pasteurella multocida, Histophilus somni and Mycoplasma bovis sensitive to tulathromycin. The presence of the disease in the herd should be established before metaphylactic treatment.Treatment of infectious bovine keratoconjunctivitis (IBK) associated with Moraxella bovis sensitive to tulathromycin.Pigs: Treatment and metaphylaxis of swine respiratory disease (SRD) associated with Actinobacillus pleuropneumoniae, Pasteurella multocida, Mycoplasma hyopneumoniae, Haemophilus parasuis and Bordetella bronchiseptica sensitive to tulathromycin. The presence of the disease in the herd should be established before metaphylactic treatment. Draxxin should only be used if pigs are expected to develop the disease within 2–3 days.Sheep: Treatment of the early stages of infectious pododermatitis (foot rot) associated with virulent Dichelobacter nodosus requiring systemic treatment.|Cattle: Treatment and metaphylaxis of bovine respiratory disease (BRD) associated with Mannheimia haemolytica, Pasteurella multocida, Histophilus somni and Mycoplasma bovis susceptible to tulathromycin. The presence of the disease in the herd should be established before metaphylactic treatment.Treatment of infectious bovine keratoconjunctivitis (IBK) associated with Moraxella bovis susceptible to tulathromycin.Pigs: Treatment and metaphylaxis of swine respiratory disease (SRD) associated with Actinobacillus pleuropneumoniae, Pasteurella multocida, Mycoplasma hyopneumoniae, Haemophilus parasuis and Bordetella bronchiseptica susceptible to tulathromycin. The presence of the disease in the herd should be established before metaphylactic treatment. The product should only be used if pigs are expected to develop the disease within 2–3 days.Sheep: Treatment of the early stages of infectious pododermatitis (foot rot) associated with virulent Dichelobacter nodosus requiring systemic treatment.

MeSH：

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

MeSH Entry Terms：

tulathromycin

Tulathromycin Use and Manufacturing

Uses

Triamilide antibiotic for treatment of bovine and porcine respiratory disease. Exists as an equilibrium mixture of two isomeric forms, Tulathromycin A (90%) and B (10%). Antibacterial.

Use Classification：

Veterinary drugs -> Draxxin -> EMA Drug Category|Antibacterials for systemic use -> Veterinary pharmacotherapeutic group|Veterinary drugs -> Tulissin -> EMA Drug Category|Veterinary drugs -> Tulaven -> EMA Drug Category|Veterinary drugs -> Lydaxx -> EMA Drug Category|Veterinary drugs -> Increxxa -> EMA Drug Category|Veterinary drugs -> Rexxolide -> EMA Drug Category|Veterinary drugs -> Tulinovet -> EMA Drug Category|Antibacterials for systemic use, Macrolides -> Veterinary pharmacotherapeutic group|Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients|Pharmaceuticals -> Animal Drugs -> Approved in Taiwan

Computed Properties

Molecular Weight:806.1
XLogP3:3.8
Hydrogen Bond Donor Count:7
Hydrogen Bond Acceptor Count:15
Rotatable Bond Count:11
Exact Mass:805.56637496
Monoisotopic Mass:805.56637496
Topological Polar Surface Area:201
Heavy Atom Count:56
Complexity:1240
Defined Atom Stereocenter Count:18
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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