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Tulathromycin A

Tulathromycin A structure

CAS No:
217500-96-4
Formula:
C41H79N3O12
Chemical Name:
Tulathromycin A
Synonyms:
TULATHROMYCIN A;(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[[2,6-Dideoxy-3-C-methyl-3-O-methyl-4-C-[(propylamino)methyl]-a-L-ribo-hexopyranosyl]oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-b-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one;Unii-897A3kn7ap;(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[[2,6-Dideoxy-3-C-Methyl-3-O-Methyl-4-C-[(propylaMino)Methyl]-α-L-ribo-hexopyranosyl]oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexaMethyl-11-[[3,4,6-trideoxy-3-(diMethylaMino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one;CP 472295;Draxxin;Tulathromycin A, >=95%;Tulathrmycin A
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Tulathromycin A is a macrolide antibiotic.IC50 Value: 1 microg/ml (MIC90 for Pasteurella multocida) [2]Target: Antibacterialin vitro: Two highly pathogenic strains of M. bovis (with minimum inhibitory concentration values for tulathromycin of 1 and >64 microg/ml) were inoculated into 145 calves. Four days after inoculation, calves with clinical BRD were treated subcutaneously with saline or tulathromycin (2.5 mg/kg). Compared with saline, BRD-related withdrawals, peak rectal temperatures

Tulathromycin A is an aminoglycoside.|Tulathromycin is a macrolide antibiotic used to treat bovine respiratory disease in cattle and swine respiratory disease in pigs. It is marketed by Pfizer Inc. under the tradename Draxxin.

Tulathromycin is a semi-synthetic macrolide antibiotic of the sub-class triamilide. It occurs as a white to off-white crystalline powder that is readily soluble in water at pH less than 8. At a pH of 7.4 (physiological pH), tulathromycin (a weak base) is 50 times more soluble in hydrophilic than hydrophobic media.

ChEBI:Tulathromycin A is an aminoglycoside.

Tulathromycin A Basic Attributes

Molecular Weight：

806.09

Exact Mass：

806.08

EC Number：

638-829-0

UNII：

897A3KN7AP

DSSTox ID：

DTXSID60274184

Color/Form：

White to Off-White

ATC Code：

QJ01FA94

Characteristics

PSA：

201

XLogP3：

3.8

Density：

1.17

Melting Point：

186-188oC

Boiling Point：

853.8±65.0 °C(Predicted)

Flash Point：

470.2±34.3 °C

Refractive Index：

1.536

PKA：

13.19±0.70(Predicted)

Collision Cross Section：

286.4 Å² [M+H]+ [CCS Type: TW]

Critical Temperature & Pressure：

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Safety Information

Precautionary statement(s)：

P261, P264, P272, P273, P280, P302+P352, P305+P351+P338, P321, P333+P313, P337+P313, P363, P501

Hazard Statements：

H317

GHS Classification：

|Danger|H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]|P201, P202, P260, P261, P264, P270, P272, P273, P280, P281, P302+P352, P305+P351+P338, P308+P313, P310, P314, P321, P333+P313, P337+P313, P363, P391, P405, and P501|Aggregated GHS information provided by 106 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

Drug Indication：

Cattle: Treatment and metaphylaxis of bovine respiratory disease (BRD) associated with Mannheimia haemolytica, Pasteurella multocida, Histophilus somni and Mycoplasma bovis sensitive to tulathromycin. The presence of the disease in the herd should be established before metaphylactic treatment.Treatment of infectious bovine keratoconjunctivitis (IBK) associated with Moraxella bovis sensitive to tulathromycin.Pigs: Treatment and metaphylaxis of swine respiratory disease (SRD) associated with Actinobacillus pleuropneumoniae, Pasteurella multocida, Mycoplasma hyopneumoniae, Haemophilus parasuis and Bordetella bronchiseptica sensitive to tulathromycin. The presence of the disease in the herd should be established before metaphylactic treatment. Draxxin should only be used if pigs are expected to develop the disease within 2–3 days.Sheep: Treatment of the early stages of infectious pododermatitis (foot rot) associated with virulent Dichelobacter nodosus requiring systemic treatment.|Cattle: Treatment and metaphylaxis of bovine respiratory disease (BRD) associated with Mannheimia haemolytica, Pasteurella multocida, Histophilus somni and Mycoplasma bovis susceptible to tulathromycin. The presence of the disease in the herd should be established before metaphylactic treatment.Treatment of infectious bovine keratoconjunctivitis (IBK) associated with Moraxella bovis susceptible to tulathromycin.Pigs: Treatment and metaphylaxis of swine respiratory disease (SRD) associated with Actinobacillus pleuropneumoniae, Pasteurella multocida, Mycoplasma hyopneumoniae, Haemophilus parasuis and Bordetella bronchiseptica susceptible to tulathromycin. The presence of the disease in the herd should be established before metaphylactic treatment. The product should only be used if pigs are expected to develop the disease within 2–3 days.Sheep: Treatment of the early stages of infectious pododermatitis (foot rot) associated with virulent Dichelobacter nodosus requiring systemic treatment.

MeSH：

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

MeSH Entry Terms：

tulathromycin

Tulathromycin A Use and Manufacturing

Uses

Triamilide antibiotic for treatment of bovine and porcine respiratory disease. Exists as an equilibrium mixture of two isomeric forms, Tulathromycin A (90%) and B (10%). Antibacterial.

Tulathromycin A is used for the treatment of pulmonary diseases in pigs and cattle.In cattle, tulathromycin is used for the treatment of rinderpest caused by Haemolytic rinderpest, polyvalent rinderpest and Haemophilus somnus (formerly Haemophilus somnus). It is also effective in the treatment of infections caused by Mycoplasma bovis. When used in high-risk calves, it is also used to prevent infections caused by these pathogens. It is also used for the treatment of bovine foot rot (interdigital necrotizing fungal disease) associated with Fusarium necrophorum and Fusarium oxysporum. A single dose is effective in bovine infectious keratoconjunctivitis (Mycobacterium bovis).In pigs, it is used to control and treat SRD associated with Actinobacillus pleuropneumoniae, Bacteroides multilocularis, Bordetella bronchiseptica, Mycoplasma pneumoniae, and Haemophilus parasiticus, and tulathromycin has been used to treat lung abscesses.

Use Classification：

Veterinary drugs -> Draxxin -> EMA Drug Category|Antibacterials for systemic use -> Veterinary pharmacotherapeutic group|Veterinary drugs -> Tulissin -> EMA Drug Category|Veterinary drugs -> Tulaven -> EMA Drug Category|Veterinary drugs -> Lydaxx -> EMA Drug Category|Veterinary drugs -> Increxxa -> EMA Drug Category|Veterinary drugs -> Rexxolide -> EMA Drug Category|Veterinary drugs -> Tulinovet -> EMA Drug Category|Antibacterials for systemic use, Macrolides -> Veterinary pharmacotherapeutic group|Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients|Pharmaceuticals -> Animal Drugs -> Approved in Taiwan

Computed Properties

Molecular Weight:806.1
XLogP3:3.8
Hydrogen Bond Donor Count:7
Hydrogen Bond Acceptor Count:15
Rotatable Bond Count:11
Exact Mass:805.56637496
Monoisotopic Mass:805.56637496
Topological Polar Surface Area:201
Heavy Atom Count:56
Complexity:1240
Defined Atom Stereocenter Count:18
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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