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Bimatoprost

Bimatoprost structure

CAS No:
155206-00-1
Formula:
C25H37NO4
Chemical Name:
Bimatoprost
Synonyms:
5-Heptenamide,7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl]-N-ethyl-,(5Z)-;5-Heptenamide,7-[3,5-dihydroxy-2-(3-hydroxy-5-phenyl-1-pentenyl)cyclopentyl]-N-ethyl-,[1R-[1α(Z),2β(1E,3S*),3α,5α]]-;5-Heptenamide,7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-pentenyl]cyclopentyl]-N-ethyl-,(5Z)-;(5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl]-N-ethyl-5-heptenamide;Bimatoprost;AGN 192024;Lumigan;Prostamide;Latisse;17-Phenyltrinor-PGF2α ethylamide;267244-98-4
Categories:
Active Pharmaceutical Ingredients > Hormones and the Endocrine System

Description

Crystalline SolidBimatoprost was first introduced in the US and Brazil as Lumigan, an ophthalmic solution (0.03%) for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension, a proven risk of glaucomatous visual field loss. Bitamoprost is a new agent belonging to the PGF2α analog class of prostamides launched in this indication after latanoprost, the most efficaceous topical medication currently available.

Bimatoprost Basic Attributes

Molecular Weight：

415.57

Exact Mass：

415.57

EC Number：

2017-001-1

Characteristics

PSA：

89.8

Appearance：

solid

Density：

1.145±0.06 g/cm3(Predicted)

Melting Point：

67-68 °C

Boiling Point：

629.8±55.0 °C(Predicted)

Flash Point：

334.7±31.5 °C

Refractive Index：

1.591

Storage Conditions：

−20°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

GHS Classification：

|Danger|H302 (11.76%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P264, P270, P280, P281, P301+P312, P302+P352, P305+P351+P338, P308+P313, P312, P322, P330, P337+P313, P363, P405, and P501|Aggregated GHS information provided by 17 companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Bimatoprost Use and Manufacturing

17-phenyl trinor Prostaglandin F2α ethyl amide (17-phenyl trinor PGF2α ethyl amide) is an F-series PG analog which has been approved for use as an ocular hypotensive drug. Investigations in our lab have shown that 17-phenyl trinor PGF2α ethyl amide is converted by an amidase enzymatic activity in the bovine and human cornea to yield the corresponding free acid, with a conversion rate of about 40 μg/g corneal tissue/24 hours. The free acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity.[Cayman Chemical]

Computed Properties

Molecular Weight:415.6
XLogP3:2.8
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:12
Exact Mass:415.27225866
Monoisotopic Mass:415.27225866
Topological Polar Surface Area:89.8
Heavy Atom Count:30
Complexity:541
Defined Atom Stereocenter Count:5
Undefined Bond Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Unspecified

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Bimatoprost eye drops
Specifications	5ml:1.5mg

Bimeisu Timolol Eye Drops
Ingredients	The main ingredients of Kefat are bimatoprost and timolol maleate.
Indication	Not yet clear.
Specifications	3ml: Bimatoprost 0.9mg and Timolol 15mg (equivalent to 20.4mg Timolol Maleate)

Bimatoprost eye drops
Ingredients	The main ingredient of this product is bimatoprost.
Indication	This product can be used with other eye drops to reduce intraocular pressure. If multiple therapeutic drugs are used at the same time, the use of each two drugs should be at least five minutes apart.
Specifications	5 ml: 1.5 mg

See More Related Drugs

Registered Holders

CAYMAN PHARMA SRO

United States
Active
EVERLIGHT CHEMICAL INDUSTRIAL CORP

United States
Active
EUROAPI Hungary Ltd

United States
Active

See More Registered Holders

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