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L(+)-Arginine

L(+)-Arginine structure

CAS No:
74-79-3
Formula:
C6H14N4O2
Chemical Name:
L(+)-Arginine
Synonyms:
ABL2 (38-end), active, His tagged human;FLJ41441;ANTI-ABL2 antibody produced in mouse;FLJ22224;FLJ31718;Abelson murine leukemia viral oncogene homolog 2;Abelson tyrosine-protein kinase 2;ABL2
Categories:
Cosmetic Ingredient > Antistatic

Description

L-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.Target: OthersL-Arginine is an α-amino acid. It was first isolated in 1886. The L-form is one of the 20 most common natural amino acids. At the level of molecular genetics, in the structure of the messenger ribonucleic acid mRNA, CGU, CGC, CGA, CGG, AGA, and AGG, are the triplets of nucleotide bases or codons that code for arginine during protein synth

Solid

Arginine is a diaminomonocarboxylic acid. The nonessential amino acid, arginine, is a urea cycle amino acid and a precursor for the neurotransmitter nitric oxide, which plays a role in the regulation of the brain’s system of dilation and constriction of small blood vessels. It is strongly alkaline and its water solutions absorb carbon dioxide from the air (FCC, 1996). Functionality in foods includes, but is not limited to, nutrient and dietary supplement

White crystalline powder

ChEBI: An L-alpha-amino acid that is the L-isomer of arginine.

L(+)-Arginine Basic Attributes

Molecular Weight：

174.2

Exact Mass：

174.20

BRN：

1725413

EC Number：

200-811-1

TSCA：

TSCA listed

Color/Form：

white

HScode：

29252000

Characteristics

λmax：

λ: 260 nm Amax: ≤0.2λ: 280 nm Amax: ≤0.1

PSA：

128

Physical Properties：

Solubility 14.87 (20 ℃) g/100 g H2O, pI 10.76, dissociation constants: pK1 2.01, pK2 9.04 (a-NH2), pK3 12.48 (guanidyl).

XLogP3：

-4.2

Appearance：

white powder

Density：

1.2297 (rough estimate)

Melting Point：

222 °C (dec.) (lit.)

Boiling Point：

305.18°C (rough estimate)

Flash Point：

176.1±30.7 °C

Refractive Index：

27 ° (C=8, 6mol/L HCl)

Water Solubility：

148.7 g/L (20 ºC)

Storage Conditions：

Storeat0-5

Toxicity：

cyt-grh-par 100 mmol/L IJEBA6 24,460,86

Flammability characteristics：

Flammable; burning produces toxic nitrogen oxide fumes

Specific rotation：

27.1 º (c=8, 6N HCl)

Odor：

Faint

PH：

10.5-12.0 (25℃, 0.5M in H2O)

PKA：

1.82, 8.99, 12.5(at 25℃)

Henrys Law Constant：

9.9×1014mol/(m3Pa) at 25℃, Saxena and Hildemann (1996)

Critical Temperature & Pressure：

2-8°C

Safety Information

Hazard category：

IRRITANT

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

Xn,T

safety instructions：

24/25-36-26-45-53-39

RTECS Number：

CF1934200

Marks：

Xn,T

Storage features：

Warehouse ventilated, low temperature and dry

Stability/Shelf Life：

Stable. Incompatible with strong oxidizing agents.

Precautionary statement(s)：

P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, P362

Hazard Statements：

36-36/37/38-20/21/22-61

Toxicity

Toxicity class：

moderately toxic

L(+)-Arginine Use and Manufacturing

Methods of Manufacturing

Gelatin is used as raw material, hydrochloric acid hydrolyzed and then condensed with benzaldehyde to obtain benzylidene arginine, and the finished product is obtained by hydrochloric acid hydrolysis, activated carbon treatment, and column chromatography.

Uses

Nitric oxide synthase substrate can be converted to citrulline and NO. Induces insulin secretion by a mechanism that depends on NO.Used as pharmaceutical raw materials and food additives. Nutritional supplements; flavoring agents. For biochemical research, various types of hepatic coma and viral hepatic alanine aminotransferase abnormalities

L-Arginine is used for heart and blood vessel conditions which includes congestive heart failure (CHF), chest pain, high blood pressure and coronary artery disease. It plays a vital role in the treatment of cardiovascular disease due to it being antiatherogenic, anti-ischemic, antiplatelet and antithrombotic. It acts as a growth stimulant and is involved in the treatment of erectile dysfunction in men. It is an important ingredient of tooth paste which provides effective relief for sensitive teeth.

Amino acid; nutrient.

L-Arginine has been used:as a Roswell park memorial institute medium (RPMI) media component in the isolation and culture of peripheral blood mononuclear cells (PBMCs)as a RPMI media component for tissue culturein DMEM medium for the identification and quantification of phosphorylation sites by stable isotope labeling by amino acids in cell culture (SILAC) and LCMS/MS

Computed Properties

Molecular Weight:174.20
XLogP3:-3.5
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:174.11167570
Monoisotopic Mass:174.11167570
Topological Polar Surface Area:132
Heavy Atom Count:12
Complexity:171
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Barium hydroxide

Drug Function and Efficacy

Amino acids are the basic units that make up human proteins and enzymes. They are the raw materials for synthesizing hormones, participate in human metabolism and various physiological functions, and play a special role in life.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Compound Amino Acid Injection (15AA)
Ingredients	This product is a compound preparation, and its components are as follows: Each 1000ml contains L-isoleucine 7.66g L-valine 8.86g L-leucine 13.78g L-alanine 4g L-lysine 4.1g L-arginine 5.8g (lysine acetate 5.8g) L-histidine 1.6g methionine 2.50g L-serine 3.3g L-phenylalanine 3.20g L-proline 6.3g L-threonine 2g glycine 3.3g<br/
Indication	Not yet clear.
Specifications	100 ml: 8 g (total amino acids)
Manufacturer	Chengdu Brilliant Pharmaceutical Co., Ltd.

Compound Amino Acid Injection (18AA)
Ingredients	The main ingredients of this product are: 18 kinds of amino acids. The amino acid content is 10%. Amino acid concentration (mg/1000ml) L-isoleucine 560 L-arginine 790 L-leucine 1,250 L-aspartic acid 380 acetate L-lysine 1,240 L-cysteine 100 (equivalent to lysine 880) L-glutamic acid 650 L-methionine 350 L-histidine 600 L-phenylalanine 935 L-proline 330 L-threonine 650 L-serine 220 L-tryptophan
Indication	Not yet clear.
Specifications	500ml:25g(total amino acids)
Manufacturer	Zhejiang Guojing Pharmaceutical Co., Ltd.

Compound Amino Acid Injection (18AA)
Ingredients	The main ingredients of this product are: 18 kinds of amino acids. The amino acid content is 10%. Amino acid concentration (mg/1000ml) L-isoleucine 560 L-arginine 790 L-leucine 1,250 L-aspartic acid 380 acetate L-lysine 1,240 L-cysteine 100 (equivalent to lysine 880) L-glutamic acid 650 L-methionine 350 L-histidine 600 L-phenylalanine 935 L-proline 330 L-threonine 650 L-serine 220 L-tryptophan
Indication	Not yet clear.
Specifications	250m1:30g (total amino acids)
Manufacturer	Hubei Changlian Dule Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

AJINOMOTO CO., INC

Pakistan
Active
Shanghai Primano Amino Acid Co., Ltd.

China
Active
Jinyao Pharmaceutical Co., Ltd.

China
Active

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Guide of L(+)-Arginine

Description
Basic Attributes
Characteristics
Safety Information
Toxicity
Use and Manufacturing
Computed Properties
Material
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Learn More Other Chemicals

L(+)-Arginine

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