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Home > Biochemical Engineering > Amino Acids and Derivatives (Find 84 items)

Amino Acids and Derivatives

Phospho-L-serine

(407-41-0)
O-Phospho-L-Serine is an agonist of the group III metabotropic glutamate receptors mGluR4a and mGluR6 (EC50s = 2-5 μM). It mimics the phosphatidylserine head group and has been shown to inhibit the proliferation of microglia and to enhance neuronal differentiation of progenitor cells.

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p-Aminohippuric acid

(61-78-9)
4-Aminohippuric Acid is used in the measurement of renal plasma flow as a diagnostic tool which may be applied towards kidney disorders.

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Pralatrexate

(146464-95-1)
An antifolate with high affinity for the reduced folate carrier-type 1, produces marked complete and durable remissions in a diversity of chemotherapy refractory cases of T-cell lymphoma.

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Phenylalanine, 4-chloro-, methyl ester, hydrochloride (1:1)

(14173-40-1)
Tryptophan hydroxylase inhibitor. Crossing the blood-brain barrier is superior to P-chlorophenylalanine.

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Potassium p-aminobenzoate

(138-84-1)
Catalyst in the manufacture of condensation polymers of polyglycol ethers.

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p-Hydroxyphenylglycine

(122-87-2)
Photographic developer.In determination of iron; detection and determination of phosphorus and silicon.Acid indicator in bacteriology.

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Pemetrexed disodium hemipenta hydrate

(357166-30-4)
Pemetrexed Disodium Hydrate is an chemotherapy drug for the treatment of pleural mesothelioma and non-small cell lung cancer. Pemetrexed Disodium Hydrate exhibit inhibitory activities towards thymidylate synthase as well as other folate dependent enzymes.

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Phospho-L-tyrosine

(21820-51-9)
O-Phospho-L-tyrosine is used in the study of tyrosine-phosphorylation, which has been linked to the malignant transformation of cells by various RNA tumor viruses. Plays a role in signal transduction.

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Amino acids are organic compounds containing basic amino groups and acidic carboxyl groups. The hydrogen atoms on the carbon atoms of carboxylic acids are replaced by amino groups. Amino acid derivatives are substances composed of amino acids through a series of reactions. Various substances in the body, such as epinephrine and thyroid hormone, are amino acid derivatives.

Frequently Asked Questions

What are Amino Acids and Derivatives used for in the pharmaceutical industry?

Amino Acids and Derivatives serve as essential building blocks in the synthesis of peptides, proteins, and active pharmaceutical ingredients (APIs). They are widely used in drug formulation, nutritional supplements, and as chiral intermediates in asymmetric synthesis. Certain derivatives also function as prodrugs or enhance drug bioavailability, making them critical in modern therapeutic development.

How do I ensure the quality of Amino Acids and Derivatives from a supplier?

To ensure high quality, verify that the supplier complies with international standards such as ISO, GMP, and REACH. Request Certificates of Analysis (CoA), review their quality control protocols, and confirm they perform rigorous testing for purity, enantiomeric excess (for chiral amino acids), and residual solvents. Reputable suppliers also provide traceability documentation and stability data.

What are common applications of Amino Acid Derivatives in biotechnology?

Amino Acid Derivatives are extensively used in biotechnology for peptide synthesis, enzyme inhibitors, cell culture media, and as components in diagnostic reagents. They also play roles in developing biosimilars, vaccine adjuvants, and targeted drug delivery systems due to their biocompatibility and structural versatility.

Are natural and synthetic Amino Acids interchangeable in pharmaceutical formulations?

Not always. While both can be chemically identical, regulatory pathways, impurity profiles, and sourcing documentation differ significantly. Natural amino acids derived from fermentation may carry biological contaminants, whereas synthetic versions offer higher batch-to-batch consistency. Regulatory agencies often require justification for interchangeability based on safety and efficacy data.

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