The covid-19 vaccine test that people around the world are concerned about! Finally, the exciting results were ushered in: the safety after vaccination was good, and there was no case of serious adverse reactions. Vaccines in the vaccine group produced high-titer antibodies after different procedures and different doses of vaccination. After two doses on the 0,28-day program, neutralization The antibody positive conversion rate reached 100%.
covid-19 Vaccine Triumph News! Subjects produce 100% antibodies!
On June 16, the blind review of phase I/II clinical trials of the new coronavirus inactivated vaccine developed by Sinopharm Wuhan Institute of Biological Products and periodic blinding sessions were held simultaneously in Beijing and Henan. Relevant experts from the State Council Joint Prevention and Control Mechanism Vaccine Class and the National Ministry of Science and Technology Biotechnology Development Center attended.
The clinical trial plan was carefully designed, and the blinding process strictly followed scientific and rigorous results. The results were inspiring, safe and effective after vaccination. The subjects in the vaccination group all produced high-titer antibodies. The 18-59 age group In the middle dose, the positive conversion rate of the neutralizing antibody reached 97.6% after the two doses were inoculated according to the 0,14 and 0,21 days. The positive conversion rate of the neutralizing antibody reached 100% according to the 0,28 days.
This is really exciting news that has been waiting for a long time. After all, just two days ago, the Beijing epidemic suddenly rebounded, causing the demand for masks and other related medical products to increase again. Beijing urgently adopts the closed-end management of the community, and the flights between the two major airports are cancelled in large areas, and some airlines are exempt from the refund processing fee.
The great progress of the vaccine has made everyone see the hope of human victory over the virus.
Relevant chemical raw material gaps open!
In the production and use of vaccines, a large number of chemicals are applied, and they are involved in inactivation, antigen extraction, and preservation procedures to ensure the function and efficacy of vaccines. Let us know about the chemicals used in vaccine development.
Formaldehyde industry chain
Compared with attenuated vaccines, the production of inactivated vaccines has a greater demand for chemicals. This is because the production of inactivated vaccines requires certain means to inactivate pathogens. In inactivation, it is necessary to use certain means to ensure that the pathogen is inactive.
Inactivation refers to a method of killing viruses, bacteria, etc. by physical (heating) or chemical means, but without damaging useful antigens in their bodies. Inactivating the virus will destroy the complex but fragile spatial structure of the virus protein, and the protein will no longer have physiological activity, so it will lose its ability to infect, cause disease and reproduce. However, conventional inactivation does not affect the primary structure of the viral protein, which means that the sequence of the viral protein has not changed, and it can still trigger a part of the immune response. Therefore, the inactivated virus is antigenic, but loses its infectivity.
Among inactivated vaccines, the more common inactivator is formaldehyde. We know that formaldehyde is not a good thing for the human body. The same is true for pathogens, especially viruses. Formaldehyde can denature proteins, and it can also interact with the amino group of nucleotides, which is not much different from the principles of formaldehyde to cause cancer and preserve cadavers. It is also used to kill unwanted viruses and bacteria during vaccine production to avoid contaminating the vaccine.
It is worth mentioning that the upstream of formaldehyde is methanol, and the downstream is MDI, resin and other chemical products. This means that with the large amount of investment in the research and development of the covid-19 vaccine, the prices of related products in the formaldehyde industry chain will be likely to skyrocket.
Excipient: Boosting the caustic soda industry chain
In a qualified vaccine, preservatives, stabilizers, and certain adjuvants are necessary. These are collectively called excipients. Due to the sensitivity of the vaccine application, the vaccine excipients can be high-purity chemical agents, and they do have an effect.
Adjuvants usually include metal salts, oils and biomolecules. Among metal salts, aluminum salts are more commonly used. This adjuvant can promote the production of antibodies.
The surge in demand for aluminum salts (* refers to alumina) will also affect the demand for caustic soda-related industrial chains.
Vaccine bottle: borosilicate industry chain
According to reports, the special packaging requirements for vaccines are selected from borosilicate glass materials, which are mainly controlled injection bottles (commonly known as vials) and pre-filled syringes. At present, China has more than 60 related packaging production enterprises, including Ningbo Zhengli, Shuangfeng Greensheim, etc., and pre-filled syringe manufacturers mainly include Shandong Weigao and Ningbo Zhengli. , Shandong Pharmaceutical Glass, BD, etc.
Borosilicate glass manufacturing, mainly boron trioxide and silicon dioxide, added water glass sand, soda water and ground lime.
Fight against the covid-19 epidemic! Normal control cannot be relaxed
Although there have been major breakthroughs in the vaccine development experiment, even if all goes well, the project will complete the second phase clinical trial as early as July this year. This also means that it takes a certain amount of time for the vaccine to be actually put on the market.
Therefore, in the case of a rebound in the domestic epidemic, we should realize that the risk of an epidemic rebound still exists, so the self-protection of the citizens cannot be relaxed.
As chemical workers, we can also pay more attention to the relevant raw materials required for vaccines when doing daily self-protection. Catch up with the rapid growth in demand for related products.
