 Home > News > Food Industry News > The EU evaluates the safety of phospholipase A10 produced by the transgenic Streptomyces viasura strain AS-2

The EU evaluates the safety of phospholipase A10 produced by the transgenic Streptomyces viasura strain AS-2

 foodmate 2023-02-13

On February 2023, 2, the European Food Safety Authority issued an opinion on the safety evaluation of a food enzyme phospholipase A1.

This food enzyme is produced from the genetically modified Streptomyces viasura strain AS-10 and is intended for use in egg processing, baking processes, degumming of fats and oils, and milk processing to produce cheese.

After evaluation, the Panel concluded that the risk of allergic reactions and induced reactions through dietary exposure could not be ruled out under the intended conditions of use, but that the likelihood of such occurrence was low. Based on the data provided, the Panel concludes that the food enzyme does not pose a safety problem under the intended conditions of use. Some of the original articles are reported below:

The food enzyme phospholipase A2 (phosphatidylcholine 2-acylhydrolase EC 3.1.1.4) is produced with the genetically modified Streptomyces violaceoruber strain AS-10 by Nagase (Europa) GmbH. The genetic modifications do not give rise to safety concerns. The food enzyme is free from viable cells of the production organism and its DNA. It is intended to be used in four food manufacturing processes, i.e. egg processing, baking processes, degumming of fats and oils and milk processing for cheese production. Since residual amounts of total organic solids (TOS) are removed in degumming of fats and oils, dietary exposure was calculated o nly for the remaining three food manufacturing processes. Dietary exposure to the food enzyme–TOS was estimated to be up to 0.41 mg TOS/kg body weight (bw) per day in European populations. Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by means of a repeated dose 90-day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 191.2 mg TOS/kg bw per day, the mid-dose tested, which, when compared with the estimated dietary exposure, results in a margin of exposure above 460. A search for similarity of the amino acid sequence of the food enzyme to known allergens was made and no matches were found. The Panel considered that, under the intended co nditions of use, the risk of allergic sensitisation and elicitation reactions by dietary exposure cannot be excluded, but the likelihood for this to occur is considered to be low. based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use.

food&nutrition trend

 Disclaimer: ECHEMI reserves the right of final explanation and revision for all the information.

Looking for chemical products? Let suppliers reach out to you!

The world's first | BASF will launch its latest compound, azinazolamide, in Australia

The EU modifies Clostridium butyrate FERM BP-2789 as a condition for the authorization of feed additives for fattening chickens, laying hens and small poultry

Comment

Comment

You May Interested In

buy Scyllo-Inositol 99% CAS No 488-59-5 Manufacturer





Daily Morning Brief

2026-07-12

Michelin, Axens in Talks to Commercialize Bio-Based 5-HMF

Aditya Birla Proposes $1.26 Billion Expansion of Odisha Alumina Refinery

Eni CEO says oil market risks breaking out of current range by early 2027

Eniâs Descalzi Says Energy Crisis May Worsen in Short Term

3M, DuPont Face PFAS Lawsuit in New York

View All

Functional Ingredients Industry Overview

Collection of Markets for Functional Ingredients in Food & Nutrition and Cosmetics.

Published in: Mar. 2026

Read Now Download

Trade Alert

Delivering the latest product trends and industry news straight to your inbox.
(We'll never share your email address with a third-party.)

Recommend Reading

Hot Searches: methyl benzoate; caprylic capric acid triglyceride; pseudomembranous colitis; cro3; teriparatide brand name; thiophene; 2-hexanone; formula for cupric oxide; baoh2; ribose 5 phosphate; structure of ipa; ferrous oxide



Feedback & Suggestions

Send Message

Thank you for your feedback. If you require further assistance, please contact us by email at info@echemi.com or call us at +86-532-55729510.

The EU evaluates the safety of phospholipase A10 produced by the transgenic Streptomyces viasura strain AS-2

The world's first | BASF will launch its latest compound, azinazolamide, in Australia

The EU modifies Clostridium butyrate FERM BP-2789 as a condition for the authorization of feed additives for fattening chickens, laying hens and small poultry

You May Interested In

Scyllo-Inositol 99% CAS No 488-59-5 Manufacturer

High Quality Potassium persulfate 99% Solid 7727-21-1-Shaanxi Dideu Medichem Co.Ltd

oxaloacetate CAS NO 328-42-7

Erythritol Pharmaceutical Ingredients 99% white powder SNC | Good Fortune

Industrial grade / Food grade Sodium Bicarbonate High-purity baking soda For food additives

High Quality Acetylcysteine Powder CAS 616-91-1 N-Acetyl-L-Cysteine / N Acetyl L Cysteine

Functional Ingredients Industry Overview

Related News

Recommend Reading