What Is Aldehyde Dehydrogenase

Definition of Aldehyde Dehydrogenase

Aldehyde dehydrogenases are a class of enzymes that use a variety of aldehydes as substrates. Aldehyde dehydrogenases have been classified according to their enzymatic properties, subcellular localization and tissue specificity. In recent years, many studies have found that some aldehydes Besides catalysis, dehydrogenase also has many other important physiological functions.

Chemical Knowledge of Aldehyde Dehydrogenase

Different influences from different types of aldehyde dehydrogenase to aromarice

Aroma is an important quality trait in food products, and aromatic rice is preferred by consumers because of its attractive aroma, which in turn generates higher economic value.

2-acetyl-1-pyrroline (2-AP) is an important volatile in aromatic rice, and different mutation types of rice betaine aldehyde dehydrogenase (BETAINE Different mutant types of ALDEHYDE DEHYDROGENASE 2 (BADH2) can all lead to the accumulation of 2-AP for aroma production (Okpala et al., 2019). Scientists found that this mechanism is conserved in rice, maize, sorghum, soybean, cucumber and other crops.

Formaldehyde is its metabolic product

Formaldehyde is both naturally produced as a metabolic product via the aldehyde dehydrogenase pathway, and artificially produced as a chemical precursor to other organic chemicals. Formaldehyde is also used in biological research and histology staining; it is frequently used to fix tissue and cell samples by cross-linking amino acids within proteins, preventing them from becoming distorted or denatured by environmental factors.

Adverse reactions on Acetaldehyde Dehydrogenasecaused by Drug Excipients 

Adverse reactions caused by the addition of excipients to drugs are related to the nature of the excipients themselves. Some excipients have certain toxicity, once the concentration is too high, or long-term use, it is possible to cause adverse reactions. For example, if propylene glycol is used as an excipient to dissolve preparations of insoluble drugs, propylene glycol will be converted into lactic acid by acetaldehyde dehydrogenase when administered in large doses, which may lead to lactic acidosis, hemolysis and other adverse reactions, and long-term high-dose infusion may also cause some damage to the kidneys.

Examples of Dehydrogenase

About Acetaldehyde Dehydrogenase

One common potential source of aldehydes is alcohol: our body converts the alcohol that we drink into acetaldehyde, one such chemical. Ordinarily, this is broken down by a natural enzyme known as acetaldehyde dehydrogenase, but over 500 million people mainly from countries such as Japan, China and Korea inherit a faulty gene, ALDH2, that inactivates this enzyme. This is why many Asian people develop flushes when they drink, but could mean they are also particularly sensitive to the cancer-promoting effect.

About Lactate Dehydrogenase

Fucoidan can effectively inhibit the spleen damage of irradiated mice, and inhibit the reduction of the number of bone marrow nucleated cells, hematopoietic stem cells and WBC. Astragalus polysaccharides can protect the liver damage of irradiated mice, and significantly reduce the levels of alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase and the expression level of NF-KB.

About phosphate Dehydrogenase

DNA and RNA, and can inhibit the activity of some microbial enzymes, including phosphate dehydrogenase, cholinesterase and choline oxidase, etc., hindering the normal metabolism of microorganisms. Ethylene oxide can effectively kill bacterial propagules, bacterial spores, mycobacteria, fungi and viruses; it also has the effect of killing harmful insects. Ethylene oxide used for disinfection of medical devices and disposable medical supplies that are not resistant to humidity and heat in hospitals has been reported in a large number of literatures. 

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