Androgen Insensitivity Syndrome in Children
Androgen insensitivity syndrome (AIS) is a common single gene sexual development disorder in children. Due to the complete or partial loss of the normal effect of androgens, it leads to a variety of clinical manifestations, ranging from a complete female phenotype to a male phenotype with only insufficient masculinization or infertility. It is the most common male pseudohermaphroditism. The disease occurs in people with a chromosome karyotype of 46, XY. In AIS, this disease is X-linked recessive inheritance and occurs in the same family.
-
Site of disease:
Male reproduction Female reproduction
-
Infectious :
Not contagious
-
Frequent population:
Newborns (less than one month old)
-
Related symptoms:
Labia fusion
Secondary amenorrhea
Gonadal dysplasia
Breast dysplasia
No axillary hair