Transsexuality is a series of morphological changes in cells or intercellular matrix accompanied by changes in structure and function (functional decline), which is manifested by the appearance of non-physiological substances or excessive accumulation of physiological substances in cells or intercellular matrix. However, the transsexuality we usually come into contact with in life is mostly the third meaning: transsexuality, which is to change the reproductive organs of a person through surgical means, such as removing male reproductive organs and transplanting female reproductive organs or removing female reproductive organs and transplanting male reproductive organs. People who usually want to change their sex (transsexuality) often suffer from transsexualism. Transsexuality (transexuals) is a serious reversal of sexual identity. Patients usually germinate at the age of 3, and their psychology reverses during adolescence. They continue to feel the contradiction or incoordination between their biological sex and psychological sex. They are convinced that they are people of another sex and strongly demand to change their sexual anatomy. For this reason, they require transsexual surgery to achieve their beliefs. When the transsexuality requirements are not met, they often suffer from extreme pain due to inner conflicts, and even lead to self-mutilation and self-destruction.