This product is an endogenous coenzyme B12, which participates in the one-carbon unit cycle and plays an important role in the transmethylation reaction of methionine synthesis from homocysteine. Animal experiments have found that this product is easier to enter neuronal organelles than cyanocobalamin, participates in the synthesis of thymidine nucleoside in brain cells and spinal cord neurons, promotes the utilization of folic acid and nucleic acid metabolism, and has a stronger effect on promoting nucleic acid and protein synthesis than cyanocobalamin. This product can promote axonal transport function and axonal regeneration, normalize the transport of axonal skeleton proteins in the sciatic nerve of diabetic rats induced by streptozotocin, and has an inhibitory effect on drug-induced neurodegeneration, such as neurodegeneration caused by doxorubicin, acrylamide, and vincristine, and neurological diseases in spontaneously hypertensive rats. In rat tissue culture, it was found that this product can promote lecithin.

This product is a long-acting tricyclic antihistamine that can relieve seasonal allergic rhinitis or non-nasal symptoms by selectively antagonizing peripheral H1 receptors.

This product is a long-acting tricyclic antihistamine that can relieve seasonal allergic rhinitis or non-nasal symptoms by selectively antagonizing peripheral H1 receptors.

A non-nucleoside reverse transcriptase inhibitor (NNRTI) of human immunodeficiency virus (HIV-1), it directly binds to the reverse transcriptase of HIV-1 and blocks the activity of RNA-dependent and DNA-dependent DNA polymerases, and has no inhibitory effect on the reverse transcriptase of HIV-2 virus and eukaryotic cell DNA polymerases. The in vitro antiviral activity was determined by peripheral blood mononuclear cells, macrophages, and lymphocytes, with an IC50 range of 10-100nM. It has a synergistic effect on HIV-1 in combination with zidovudine, didanosine, stavudine, lamivudine, saquinavir, and indinavir.

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) of human immunodeficiency virus (HIV-1) bind directly to the reverse transcriptase (RT) of HIV-1 and block both RNA-dependent and DNA-dependent DNA polymerase activity by cleaving the catalytic end of the enzyme without competing with substrates or nucleoside triphosphates.