Unspecified

Artemisia selengensis is a sesquiterpene lactone drug with peroxide groups extracted from the traditional Chinese medicine Artemisia selengensis. Its effect on the ultrastructure of the erythrocytic stage of Plasmodium malariae is mainly the change of the membrane structure of the parasite. The drug first acts on the food vacuole membrane, the surface membrane, mitochondria, and the endoplasmic reticulum. In addition, it also has a certain effect on the chromatin in the nucleus. It is suggested that the mode of action of artemisia selengensis is mainly to interfere with the function of the surface membrane-mitochondria. It is possible that artemisia selengensis acts on the food vacuole membrane, thereby blocking the earliest stage of nutrient intake, causing the parasite to starve for amino acids more quickly, quickly forming autophagic vacuoles, and continuously excreting them from the parasite, causing the parasite to lose a large amount of cytoplasm and die. The uptake of tritium-labeled isoleucine by Plasmodium falciparum cultured in vitro also shows that its initial mode of action may be to inhibit the synthesis of protozoan proteins.

Adjust the pH value of urine, suitable for the dissolution and excretion of calcium oxalate, uric acid, urate, and cystine stones

Adjust the pH value of urine, suitable for the dissolution and excretion of calcium oxalate, uric acid, urate, and cystine stones

Adjust the pH value of urine, suitable for the dissolution and excretion of calcium oxalate, uric acid, urate, and cystine stones

Adjust the pH value of urine, suitable for the dissolution and excretion of calcium oxalate, uric acid, urate, and cystine stones

Adjust the pH value of urine, suitable for the dissolution and excretion of calcium oxalate, uric acid, urate, and cystine stones

Adjust the pH value of urine, suitable for the dissolution and excretion of calcium oxalate, uric acid, urate, and cystine stones

Adjust the pH value of urine, suitable for the dissolution and excretion of calcium oxalate, uric acid, urate, and cystine stones

Adjust the pH value of urine, suitable for the dissolution and excretion of calcium oxalate, uric acid, urate, and cystine stones

Adjust the pH value of urine, suitable for the dissolution and excretion of calcium oxalate, uric acid, urate, and cystine stones

Vinblastine is an alkaloid with anti-cancer activity extracted from the Apocynaceae plant Catharanthus roseus. It mainly inhibits the polymerization of tubulin, hinders the formation of spindle microtubules, and stops mitosis at metaphase. It can also act on the cell membrane, interfere with the transport of amino acids by the cell membrane, inhibit protein synthesis, and inhibit RNA synthesis. Vinblastine has a wide anti-tumor spectrum. At a dose of 0.05-0.1 mg/kg, it has obvious anti-tumor activity against mouse L1210 leukemia, Ehrlich ascites carcinoma, S180, C3H mouse spontaneous and metastatic breast cancer, etc. It also has an inhibitory effect on the growth of choriocarcinoma cells transplanted in hamster cheek pouches.

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