Haikou Pharmaceutical Factory Co., Ltd.

This product is a broad-spectrum semi-synthetic penicillin with extremely low toxicity. The antibacterial spectrum is similar to that of penicillin, and it has a strong antibacterial effect on grass-green streptococci, hemolytic streptococci, and enterococci. Diphtheria bacillus, anthrax bacillus, Gram-positive anaerobic cocci and bacilli are sensitive to this product; meningococci, pertussis bacilli, and Brucella are also very sensitive. Escherichia coli, Salmonella, Shigella dysenteriae, Proteus, influenza bacilli, pneumococci, gonococci, etc., all have varying degrees of drug resistance because some strains produce beta-lactamase. Among them, the resistance rate of Escherichia coli is as high as 50-60%. Enterobacter bacteria, Pseudomonas aeruginosa, and anaerobic Gram-negative bacilli are resistant to this product. This product is mainly used to treat infectious diseases caused by sensitive Staphylococcus aureus, hemolytic streptococci, gonococci, meningococci and diphtheria Bordetella, pertussis Bordetella, influenza Bordetella, Salmonella, Shigella, etc.; such as respiratory tract infections (pneumonia, acute and chronic bronchitis, whooping cough, etc.), gastroenteritis and digestive tract infections (liver and gallbladder infections, acute and chronic gastroenteritis, bacillary dysentery, typhoid and paratyphoid, etc.), urinary tract infections (gonorrhea, urethritis, cystitis, etc.), soft tissue infections and sepsis, meningitis, endocarditis, etc.

It has a direct relaxant effect on the smooth muscles of the respiratory tract; partly by inhibiting phosphodiesterase, thereby increasing the intracellular cAMP content; partly as a result of the release of endogenous adrenaline and norepinephrine; it can counteract the contractile effect of adenine and other substances on the respiratory tract; it enhances the contractility of the diaphragm and improves respiratory function.

It has an antipyretic effect on rabbits with fever caused by bacterial endotoxins; it can counteract the increased permeability of capillary walls caused by xylene or histamine; it has a significant sedative effect; it promotes the function of the adrenal cortex of rats and enhances the body's emergency response to pathogen infection; it has a certain inactivation effect on influenza virus type A1, type A3, pneumonia adenovirus (Adv) type III, type IV, enterosyncytial virus and respiratory syncytial virus (RSV) in vitro.

It achieves bactericidal effect by inhibiting biosynthesis of sensitive bacterial cell walls. It has obvious synergistic effect when used in combination with sulbactam, enhancing the effect on drug-resistant strains.

It has an irreversible inhibitory effect on most important β-lactamases produced by β-lactam antibiotic-resistant strains, protecting β-lactam antibiotics from hydrolysis. It can also combine with certain penicillin-binding proteins to enhance its effect on sensitive strains.