Amoxicillin is a broad-spectrum penicillin antibiotic, which can protect it from hydrolysis by β-lactamase when used in combination with potassium clavulanate. It has good effects on enzyme-producing Staphylococcus aureus, Staphylococcus epidermidis, coagulase-negative Staphylococci and enterococci, and also has good antibacterial activity against certain β-lactamase-producing Enterobacteriaceae, Haemophilus influenzae, Moraxella catarrhalis, Bacteroides fragilis, etc.

Potassium clavulanate itself has only weak antibacterial activity, but it has a strong broad-spectrum β-lactamase inhibitory effect and can protect amoxicillin from β-lactamase hydrolysis.

Ticarcillin is a broad-spectrum penicillin-type bactericidal agent, and clavulanic acid restores the sensitivity of ticarcillin to bacteria by blocking β-lactamase.

Clavulanic acid is an irreversible and highly effective β-lactamase inhibitor. It has little antibacterial effect alone, but when used in combination with ticarcillin, it becomes an antibiotic with broad-spectrum bactericidal effect.

No specific pharmacological effects mentioned

Extract from the above information

The antibacterial spectrum is broader than that of ampicillin and carbenicillin, and it has high activity against both Gram-positive bacteria (including anaerobic cocci and bacilli) and Gram-negative bacteria. Its antibacterial effect is 7 to 10 times stronger than that of carbenicillin against mouse infection caused by Pseudomonas aeruginosa, 2 to 15 times stronger against Escherichia coli, 8 times stronger against Klebsiella pneumoniae, and 2 times stronger against hemolytic Streptococcus.