Shandong Lukang Pharmaceutical Co., Ltd.

It is a penicillin antibiotic. When combined with sulbactam sodium, it is not only protected from enzymatic hydrolysis, but also has a broader antibacterial spectrum. It has antibacterial activity against enzyme-producing strains of Staphylococcus aureus, Streptococcus, Pneumococcus, Enterococcus, Haemophilus influenzae, Moraxella catarrhalis, Escherichia coli, Klebsiella, Proteus mirabilis, Proteus vulgaris, Neisseria gonorrhoeae, Fusobacterium, Peptococcus, Peptostreptococcus and Bacteroides including Bacteroides fragilis.

It is a semi-synthetic β-lactamase inhibitor with strong antibacterial activity against Neisseria gonorrhoeae, Neisseria meningitidis and Acinetobacter calcoaceticus, but has very poor effects on other bacteria. However, it has a strong and irreversible competitive inhibitory effect on β-lactamase produced by Staphylococcus aureus and most Gram-negative bacteria. When combined with ampicillin sodium, it expands the antibacterial spectrum and also has good antibacterial activity against enzyme-producing strains of Staphylococci, Acinetobacter and Bacteroides fragilis.

Penicillin antibiotics, when combined with sulbactam sodium, not only protect them from enzymatic hydrolysis, but also expand the antibacterial spectrum, and have antibacterial activity against enzyme-producing strains of Staphylococcus aureus, Streptococcus, Pneumococcus, Enterococcus, Haemophilus influenzae, Moraxella catarrhalis, Escherichia coli, Klebsiella, Proteus mirabilis, Proteus vulgaris, Neisseria gonorrhoeae, Fusobacterium, Peptococcus, Peptostreptococcus and Bacteroides including Bacteroides fragilis.

Semi-synthetic β-lactamase inhibitor, with strong antibacterial activity against Neisseria gonorrhoeae, Neisseria meningitidis and Acinetobacter calcoaceticus, and strong irreversible competitive inhibition of β-lactamase produced by Staphylococcus aureus and most Gram-negative bacteria. It can expand the antibacterial spectrum when combined with ampicillin sodium.

Broad-spectrum semi-synthetic penicillin has antibacterial effects on gram-positive and gram-negative bacteria. It has strong antibacterial effects on hemolytic streptococci, pneumococci and non-penicillinase-producing staphylococci, which is similar to or slightly inferior to penicillin. It also has good antibacterial effects on viridans streptococci, and is better than penicillin on enterococci and listeria. It is effective against Corynebacterium diphtheriae, Bacillus anthracis, Actinomyces, Haemophilus influenzae, Bordetella pertussis, Neisseria, etc.

Acid-resistant and enzyme-resistant semi-synthetic penicillin, effective against penicillin-resistant Staphylococcus aureus. When used in combination with ampicillin, they can enhance each other's effects and make up for the shortcomings of each used alone.

Amoxicillin is a broad-spectrum penicillin antibiotic, which can be used in combination with potassium clavulanate to protect it from hydrolysis by β-lactamase. It has a good effect on enzyme-producing Staphylococcus aureus, Staphylococcus epidermidis, coagulase-negative Staphylococci and enterococci, and also has good antibacterial activity against certain β-lactamase-producing Enterobacteriaceae, Haemophilus influenzae, Moraxella catarrhalis, Bacteroides fragilis, etc.

Potassium clavulanate itself has only weak antibacterial activity, but it has a strong broad-spectrum β-lactamase inhibitory effect and can protect amoxicillin from β-lactamase hydrolysis.

Amoxicillin is a broad-spectrum penicillin antibiotic, which can protect it from hydrolysis by β-lactamase when used in combination with potassium clavulanate. It has good effects on enzyme-producing Staphylococcus aureus, Staphylococcus epidermidis, coagulase-negative Staphylococci and enterococci, and also has good antibacterial activity against certain β-lactamase-producing Enterobacteriaceae, Haemophilus influenzae, Moraxella catarrhalis, Bacteroides fragilis, etc.

Potassium clavulanate itself has only weak antibacterial activity, but it has a strong broad-spectrum β-lactamase inhibitory effect and can protect amoxicillin from β-lactamase hydrolysis.