This product is a bone resorption inhibitor. At low doses, it inhibits osteoclast activity, prevents bone resorption, and reduces bone turnover rate to achieve bone calcium regulation.

Metformin is a type of hypoglycemic drug that improves glucose tolerance in patients with type 2 diabetes. It not only lowers basal blood sugar, but also lowers postprandial blood sugar. Its pharmacological mechanism of action is different from other types of oral hypoglycemic drugs. Metformin reduces hepatic gluconeogenesis, reduces glucose absorption in the small intestine, and improves insulin sensitivity by increasing the uptake and utilization of glucose by peripheral tissues. Unlike sulfonylureas, metformin does not cause hypoglycemia (except in special circumstances) or hyperinsulinemia in patients with type 2 diabetes or normal people. Although treatment with metformin may reduce fasting islet levels and plasma insulin response throughout the day, insulin secretion usually does not change.

Palonosetron is a selective antagonist of the 5-HT3 receptor with strong affinity, and has no affinity or low affinity for other receptors. The 5-HT3 receptor is located in the central and peripheral vagus nerve endings of the emetic chemotherapy receptor area in the medulla oblongata. Chemotherapy drugs stimulate the release of 5-HT by chromaffin cells in the small intestine, and 5-HT then activates the 5-HT3 receptors of the vagal afferent nerves, producing a vomiting reflex.

It binds to the sulfonylurea receptors on the pancreatic β-cell membrane, inhibits the ATP-sensitive K channels on the pancreatic β-cell membrane, causes cell depolarization, and increases the intracellular Ca2 concentration, thereby promoting insulin secretion and lowering blood sugar.

Mitiglinide binds to the sulfonylurea receptors on the pancreatic β-cell membrane, inhibiting the ATP-sensitive K channels on the pancreatic β-cell membrane, causing cell depolarization and increased intracellular Ca2 concentration, thereby promoting insulin secretion and lowering blood sugar.