Extract from the above information

1. Clonidine is an alpha receptor agonist. 2. It stimulates the alpha 2 receptors of the central postsynaptic membrane of the hypothalamus and medulla oblongata, reduces the outflow of central sympathetic nerve impulses, and inhibits peripheral sympathetic nerve activity; it stimulates the alpha 2 receptors of the presynaptic membrane of peripheral sympathetic nerves, reduces the release of norepinephrine, reduces peripheral vascular and renal vascular resistance, slows heart rate, and lowers blood pressure. 3. It moderately reduces cardiac output when lying without changing peripheral vascular resistance, and slightly reduces cardiac output and peripheral vascular resistance when tilted. 4. After long-term treatment, cardiac output tends to normal, but peripheral vascular resistance continues to decrease. 5. It reduces plasma renin activity and aldosterone and catecholamine secretion. 6. Acute use stimulates the release of growth hormone, but long-term use does not cause a continuous increase in growth hormone levels. 7. It can be used to treat migraine, dysmenorrhea, and menopausal hot flashes, which may work by stabilizing peripheral blood vessels, or by inhibiting the activity of alpha receptors in the brain to quit opioid addiction.

Analgesic, keratolytic and antifungal effects

Antibacterial effect

Antibacterial effect

Anti-inflammatory, antipruritic, anti-swelling and analgesic effects

It has both histamine H1 receptor antagonism and the effect of inhibiting the release of allergic reaction mediators. It not only has a strong anti-allergic effect, but also has a longer duration of efficacy. Therefore, it is more effective in preventing various bronchial asthma attacks and exogenous asthma than endogenous asthma.