North China Pharmaceutical Company.Ltd

It participates in methyl conversion and folic acid metabolism in the body, promotes the conversion of methylmalonic acid into succinic acid, and thus participates in the tricarboxylic acid cycle. It plays an important role in the synthesis of nerve myelin lipids and maintaining the functional integrity of sheathed nerve fibers.

It has good antibacterial effect on hemolytic streptococci and other streptococci, Streptococcus pneumoniae and non-penicillinase-producing Staphylococci. It has moderate antibacterial effect on enterococci. Neisseria gonorrhoeae, Neisseria meningitidis, Corynebacterium diphtheriae, Bacillus anthracis, Actinomyces bovis, Streptobacillus moniliformis, Listeria monocytogenes, Leptospira and Treponema pallidum are sensitive to this product. It also has certain antibacterial activity against Haemophilus influenzae and Bordetella pertussis. It has good antibacterial effect on anaerobic bacteria such as Clostridium, Streptococcus and melanin-producing Bacteroides, but poor antibacterial effect on Bacteroides fragilis. It exerts bactericidal effect by inhibiting bacterial cell wall synthesis.

It binds to FK binding protein-12 (FKBP-12) to form an immunosuppressive complex, inhibiting mTOR activity, thereby blocking cytokine-driven T cell proliferation (development from G1 phase to S phase). It can prolong the survival of allogeneic transplants in various animal models and inhibit immune-mediated reactions associated with autoimmune diseases. It is non-genotoxic, but may increase the incidence of malignant lymphoma and testicular adenoma at high doses. It is toxic to embryos but not teratogenic.

It has antipyretic and analgesic effects, has fewer adverse reactions than aspirin, is easy to tolerate, is not hydrolyzed in the gastrointestinal tract after oral administration, is absorbed in the intestine and quickly reaches an effective concentration in the blood, and is characterized by rarely causing gastrointestinal bleeding

Participate in the formation of coenzymes in the body and prevent vitamin B1 deficiency

It binds to the 50s ribosome subunit of the sensitive vitamin, thereby interfering with its protein synthesis (but not affecting nucleic acid synthesis). It is effective against the following pathogens: Gram-positive aerobic microorganisms, Gram-negative aerobic microorganisms, other microorganisms, avian intracellular mycobacterium complex, etc. The beta-lactamase produced by bacteria does not affect the activity of azithromycin.