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When used in combination with sulbactam sodium, the MIC of Staphylococcus aureus, Haemophilus influenzae, Escherichia coli, Bacteroides fragilis, etc., which are resistant to penicillins and cephalosporins due to enzyme production, can be reduced to within the sensitive range.

This product is a semi-synthetic β-lactamase inhibitor. It has strong antibacterial activity against Neisseria gonorrhoeae, Neisseria meningitidis and Acinetobacter calcoaceticus. It has poor effects on other bacteria, but has strong and irreversible competitive inhibition of β-lactamase produced by Staphylococcus aureus and most Gram-negative bacteria. The concentration of 2mg/L has a strong inhibitory effect on Richmond classification type Ⅱ, Ⅲ, Ⅳ and Ⅴ β-lactamase, but has a poor effect on type Ⅰ β-lactamase. It has a strong affinity for PBP1 of Bacillus paradoxus and PBP2 of Acinetobacter calcoaceticus.

When used in combination with sulbactam sodium, it can reduce the MIC of Staphylococcus aureus, Haemophilus influenzae, Escherichia coli, Bacteroides fragilis, etc., which are resistant to penicillins and cephalosporins due to enzyme production, to within the sensitive range. It has a strong affinity for PBP1 of Bacillus paradoxalis.

It is a semi-synthetic β-lactamase inhibitor with strong antibacterial activity against Neisseria gonorrhoeae, Neisseria meningitidis and Acinetobacter calcoaceticus, but poorly against other bacteria. It has a strong and irreversible competitive inhibitory effect on β-lactamases produced by Staphylococcus aureus and most Gram-negative bacteria. A concentration of 2 mg/L has a strong inhibitory effect on Richmond classification type II, III, IV and V β-lactamases, but has a poor effect on type I β-lactamases. It has a strong affinity for PBP2 of Acinetobacter calcoaceticus.

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