This product belongs to the third generation of cephalosporin, with a broad-spectrum antibacterial effect, and is stable against broad-spectrum β-lactamases (including penicillinase and cephalosporinase) produced by various Gram-positive and Gram-negative bacteria. It has a strong antibacterial effect on Enterobacteriaceae such as Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis. Pseudomonas and Acinetobacter species such as Pseudomonas aeruginosa are less sensitive to this product. Ceftizoxime has a good antibacterial effect on Haemophilus influenzae and Neisseria gonorrhoeae. Its effect on Staphylococcus aureus and Staphylococcus epidermidis is worse than that of the first and second generation cephalosporins. Methicillin-resistant Staphylococcus aureus and Enterococcus are resistant to this product, and various streptococci are highly sensitive to this product. Anaerobic bacteria such as Peptococcus, Peptostreptococcus and some Bacteroides are mostly sensitive to this product, and Clostridium difficile is resistant to this product. The mechanism of action of this product is to achieve bactericidal effect by inhibiting the biosynthesis of bacterial cell wall mucopeptides.

The antibacterial effect on Gram-positive cocci and bacilli (including anaerobic bacteria) is basically the same as that of penicillin, and the effect on Enterococcus faecalis is stronger than that of penicillin. Among Gram-negative bacteria, Neisseria meningitidis, Neisseria gonorrhoeae, Haemophilus influenzae, Bordetella pertussis, Brucella, Proteus mirabilis, Salmonella, etc. are sensitive to this product. Some Escherichia coli and some Shigella are also sensitive to this product, but most Shigella are resistant to this product. Other Enterobacteriaceae, Pseudomonas aeruginosa, Bacteroides fragilis, etc. are resistant to this product. This product has a certain antibacterial effect on Legionella and Campylobacter fetus. The mechanism of action of this product is to inhibit the synthesis of bacterial cell walls, causing the bacteria to rupture and dissolve rapidly.

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It has high antibacterial activity against common aerobic Gram-positive bacteria, such as Staphylococcus aureus (including those resistant to penicillin G), Staphylococcus epidermidis, β-hemolytic Streptococcus, viridans Streptococcus and Streptococcus pneumoniae. It has good antibacterial effect on anaerobic bacteria, including Clostridium tetani, Corynebacterium diphtheriae and Clostridium perfringens. It has no activity against Gram-negative bacteria such as Enterococcus, meningococci, Neisseria gonorrhoeae and Haemophilus influenzae, as well as fungi. There is no cross-resistance with penicillin, chloramphenicol, cephalosporins and tetracyclines, and there is partial cross-resistance with macrolides. Its mechanism of action is that the 50S subunit of the ribosome of sensitive bacteria prevents the extension of the peptide chain, thereby inhibiting the protein synthesis of bacterial cells. It is generally bacteriostatic, but at high concentrations, it also has a bactericidal effect on some bacteria.