This product is a congener of chloramphenicol. Its antibacterial spectrum and antibacterial effect are similar to those of chloramphenicol. It has a broad-spectrum antimicrobial effect, including aerobic Gram-negative and Gram-positive bacteria, anaerobic bacteria, Rickettsia, spirochetes and Chlamydia. It has bactericidal effects on Haemophilus influenzae, Streptococcus pneumoniae and Neisseria meningitidis; it only has antibacterial effects on anaerobic bacteria such as Staphylococcus aureus, Streptococcus pyogenes, Streptococcus viridans, Group B hemolytic Streptococcus, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Salmonella typhi, Salmonella paratyphi, Shigella, Bacteroides fragilis, etc. Pseudomonas aeruginosa, Acinetobacter, Enterobacter, Serratia marcescens, indole-positive Proteus, methicillin-resistant Staphylococcus and Enterococcus are usually resistant to chloramphenicol. This product is an antibacterial agent, which reversibly binds to the 50S subunit of bacterial ribosomes, inhibits peptide chain formation, prevents protein synthesis, and is completely cross-resistant to chloramphenicol. Since thiamphenicol does not bind to glucuronic acid in the liver, it has high antibacterial activity in vivo. It also has a strong immunosuppressive effect, which is about 6 times stronger than chloramphenicol.

In acute toxicity experiments, the LD50 in mice and rats was greater than 4000 mg/Kg. In subacute toxicity experiments, Wistar male and female rats were given 40 mg, 200 mg and 1000 mg/Kg per day for 5 weeks, and male and female rabbits were given 6 mg, 60 mg and 600 mg/Kg per day for 23 consecutive days. There were no special changes in the blood, urine and morphological observations of the test animals. In chronic toxicity experiments, Wistar male and female rats were given 6 mg, 60 mg and 600 mg/Kg per day for 26 consecutive weeks. There were no special changes in the general state, blood and urine examinations, and morphological observations of the test animals.

In acute toxicity experiments, the LD50 in mice and rats was greater than 4000 mg/Kg. In subacute toxicity experiments, Wistar male and female rats were given 40 mg, 200 mg and 1000 mg/Kg per day for 5 weeks, and male and female rabbits were given 6 mg, 60 mg and 600 mg/Kg per day for 23 consecutive days. There were no special changes in the blood, urine and morphological observations of the test animals. In chronic toxicity experiments, Wistar male and female rats were given 6 mg, 60 mg and 600 mg/Kg per day for 26 consecutive weeks. There were no special changes in the general state, blood and urine examinations, and morphological observations of the test animals.

In acute toxicity experiments, the LD50 in mice and rats was greater than 4000 mg/Kg. In subacute toxicity experiments, Wistar male and female rats were given 40 mg, 200 mg and 1000 mg/Kg per day for 5 weeks, and male and female rabbits were given 6 mg, 60 mg and 600 mg/Kg per day for 23 consecutive days. There were no special changes in the blood, urine and morphological observations of the test animals. In chronic toxicity experiments, Wistar male and female rats were given 6 mg, 60 mg and 600 mg/Kg per day for 26 consecutive weeks. There were no special changes in the general state, blood and urine examinations, and morphological observations of the test animals.

It can combine with cholesterol to form esters, and may promote its degradation into bile acid for excretion, which has the effect of lowering blood cholesterol, reducing the content of triglycerides, low-density lipoproteins and very low-density lipoproteins, and increasing the content of high-density lipoproteins. It changes the distribution of cholesterol in the body, reduces the deposition of lipids in the blood vessel wall, and can change the composition and structure of lipoproteins, increase the fluidity of cell membranes and lipoproteins, and improve or protect the function of blood vessel walls.

It is converted into pyridoxal phosphate in red blood cells and acts as a coenzyme in various metabolic functions of proteins, carbohydrates, and lipids. It is also involved in the conversion of tryptophan into niacin or 5-hydroxytryptamine.

It is necessary for the formation of antibodies and collagen, tissue repair (including certain redox reactions), metabolism of phenylalanine, tyrosine, folic acid, utilization of iron, carbohydrates, synthesis of fat and protein, maintenance of immune function, hydroxylation of 5-hydroxytryptamine, maintaining vascular integrity, and promoting absorption of non-heme iron.

Its exact function is still unknown, but it is an antioxidant.

It has the effect of lowering blood lipids, can combine with fatty acids, phosphoric acid, etc. to form inositol phospholipids, and has an effect similar to choline, which can promote fat metabolism in the liver and other tissues and prevent fat accumulation in the liver.