Like vitamin B1, active thiamine combines with pyrophosphate in the body to form a cocarboxylase, which participates in the oxidative decarboxylation reaction of pyruvate and alpha-ketoglutaric acid in sugar metabolism and is necessary for sugar metabolism. When it is deficient, oxidation is blocked to form pyruvate, lactic acid accumulates, and affects the body's energy supply. Its symptoms are mainly manifested in the nervous and cardiovascular systems, with multiple peripheral neuritis affecting both sensory nerves and motor nerves, manifested as paresthesia, neuralgia, limb weakness, and muscle soreness and atrophy. In terms of cardiovascular system, due to the increase of acetone and lactic acid in the blood, the arterioles are dilated, the diastolic pressure is reduced, and the myocardial metabolism is disturbed, so it is easy to have symptoms of heart failure such as palpitations, shortness of breath, chest tightness, cardiac hypertrophy, liver and lung congestion and peripheral edema. In terms of the digestive tract, it is manifested as decreased appetite, leading to weakness and weight loss.

Like vitamin B1, active thiamine combines with pyrophosphate in the body to form a cocarboxylase, participates in the oxidative decarboxylation reaction of pyruvate and α-ketoglutaric acid in sugar metabolism, and is necessary for sugar metabolism. When it is deficient, oxidation is blocked to form pyruvate, lactic acid accumulates, and affects the body's energy supply. Its symptoms are mainly manifested in the nervous and cardiovascular systems, and multiple peripheral neuritis affecting both sensory nerves and motor nerves occurs, manifested as paresthesia, neuralgia, limb weakness, and muscle soreness and atrophy. In terms of cardiovascular, due to the increase of acetone and lactic acid in the blood, the small arteries are dilated, the diastolic pressure is reduced, and the myocardial metabolism is disturbed, so it is easy to have symptoms of heart failure such as palpitations, shortness of breath, chest tightness, cardiac hypertrophy, liver and lung congestion and peripheral edema. In terms of the digestive tract, it is manifested as decreased appetite.

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Adrenergic nerve blockers can hinder the storage of mediators in adrenergic nerve endings and deplete the mediators with pressor effects in the vesicles.

Diuretic antihypertensive drugs can increase the antihypertensive effect of reserpine and hydralazine sulfate; they can also reduce their side effects of water and sodium retention.

Reserpine is an adrenergic nerve blocker that can hinder the storage of mediators in adrenergic nerve endings and deplete mediators with pressor effects in vesicles. Hydralazine sulfate is a vasodilator that relaxes arteriolar smooth muscle and reduces peripheral resistance. Hydrothiazide is a diuretic and antihypertensive drug. The combined use of the three drugs has a significant synergistic effect and promotes a decrease in blood pressure. The combined use of the sympathetic nerve inhibitor reserpine, the vasodilator hydralazine sulfate and the diuretic and antihypertensive hydrothiazide has a synergistic effect, improves the efficacy, reduces the dosage, and thus reduces the adverse reactions of each drug. At the same time, hydrochlorothiazide can increase the antihypertensive effect of reserpine and hydralazine sulfate; it can also reduce their side effects of water and sodium retention.

Reserpine is an adrenergic nerve blocker that can hinder the storage of mediators in adrenergic nerve endings and deplete mediators with pressor effects in vesicles. Hydralazine sulfate is a vasodilator that relaxes arteriolar smooth muscle and reduces peripheral resistance. Hydrothiazide is a diuretic and antihypertensive drug. The combined use of the three drugs has a significant synergistic effect and promotes a decrease in blood pressure. The combined use of the sympathetic nerve inhibitor reserpine, the vasodilator hydralazine sulfate and the diuretic and antihypertensive hydrothiazide has a synergistic effect, improves the efficacy, reduces the dosage, and thus reduces the adverse reactions of each drug. At the same time, hydrochlorothiazide can increase the antihypertensive effect of reserpine and hydralazine sulfate; it can also reduce their side effects of water and sodium retention.

Reserpine is an adrenergic nerve blocker that can hinder the storage of mediators in adrenergic nerve endings and deplete mediators with pressor effects in vesicles. Hydralazine sulfate is a vasodilator that relaxes arteriolar smooth muscle and reduces peripheral resistance. Hydrothiazide is a diuretic and antihypertensive drug. The combined use of the three drugs has a significant synergistic effect and promotes a decrease in blood pressure. The combined use of the sympathetic nerve inhibitor reserpine, the vasodilator hydralazine sulfate and the diuretic and antihypertensive hydrothiazide has a synergistic effect, improves the efficacy, reduces the dosage, and thus reduces the adverse reactions of each drug. At the same time, hydrochlorothiazide can increase the antihypertensive effect of reserpine and hydralazine sulfate; it can also reduce their side effects of water and sodium retention.

Reserpine is an adrenergic nerve blocker that can hinder the storage of mediators in adrenergic nerve endings and deplete mediators with pressor effects in vesicles. Hydralazine sulfate is a vasodilator that relaxes arteriolar smooth muscle and reduces peripheral resistance. Hydrothiazide is a diuretic and antihypertensive drug. The combined use of the three drugs has a significant synergistic effect and promotes a decrease in blood pressure. The combined use of the sympathetic nerve inhibitor reserpine, the vasodilator hydralazine sulfate and the diuretic and antihypertensive hydrothiazide has a synergistic effect, improves the efficacy, reduces the dosage, and thus reduces the adverse reactions of each drug. At the same time, hydrochlorothiazide can increase the antihypertensive effect of reserpine and hydralazine sulfate; it can also reduce their side effects of water and sodium retention.

Reserpine is an adrenergic nerve blocker that can hinder the storage of mediators in adrenergic nerve endings and deplete mediators with pressor effects in vesicles. Hydralazine sulfate is a vasodilator that relaxes arteriolar smooth muscle and reduces peripheral resistance. Hydrothiazide is a diuretic and antihypertensive drug. The combined use of the three drugs has a significant synergistic effect and promotes a decrease in blood pressure. The combined use of the sympathetic nerve inhibitor reserpine, the vasodilator hydralazine sulfate and the diuretic and antihypertensive hydrothiazide has a synergistic effect, improves the efficacy, reduces the dosage, and thus reduces the adverse reactions of each drug. At the same time, hydrochlorothiazide can increase the antihypertensive effect of reserpine and hydralazine sulfate; it can also reduce their side effects of water and sodium retention.

Vasodilators, which relax arteriolar smooth muscle and reduce peripheral resistance

Reserpine is an adrenergic nerve blocker that can hinder the storage of mediators in adrenergic nerve endings and deplete mediators with pressor effects in vesicles. Hydralazine sulfate is a vasodilator that relaxes arteriolar smooth muscle and reduces peripheral resistance. Hydrothiazide is a diuretic and antihypertensive drug. The combined use of the three drugs has a significant synergistic effect and promotes a decrease in blood pressure. The combined use of the sympathetic nerve inhibitor reserpine, the vasodilator hydralazine sulfate and the diuretic and antihypertensive hydrothiazide has a synergistic effect, improves the efficacy, reduces the dosage, and thus reduces the adverse reactions of each drug. At the same time, hydrochlorothiazide can increase the antihypertensive effect of reserpine and hydralazine sulfate; it can also reduce their side effects of water and sodium retention.

It has a peripheral anti-M cholinergic receptor effect, can relieve smooth muscle spasms caused by acetylcholine, can also relieve microvascular spasms, improve microcirculation, relax gastrointestinal smooth muscle, and inhibit its peristalsis. Its effect is slightly weaker than atropine, and its effect of inhibiting digestive gland secretion is 1/10 of atropine. Its effect of inhibiting saliva secretion and dilating pupils is weaker, which is 1/20-1/10 of atropine. Because it is not easy to pass through the blood-cerebrospinal fluid barrier, its central effect is also weaker than atropine.