CSPC Zhongnuo PHARMACEUTICAL(Shijiazhuang) Co., Ltd.

It is a semi-synthetic broad-spectrum penicillin antibiotic that mainly acts on the bacterial reproduction stage by inhibiting the biosynthesis of cell wall mucopolypeptides. It is effective against many Gram-positive and Gram-negative bacteria.

It has a β-lactam structure similar to penicillin and has only weak antibacterial activity itself, but it can inactivate enzymes produced by many bacteria by blocking the active site of β-lactamase, especially for clinically important plasmid-mediated β-lactamases (these enzymes are usually related to changes in penicillin and cephalosporin resistance). It can protect amoxicillin from hydrolysis and destruction by β-lactamase, so it is still effective against resistant bacteria that produce β-lactamase.

Ampicillin sodium is a broad-spectrum semi-synthetic penicillin. This product has a strong antibacterial effect on hemolytic streptococci, Streptococcus pneumoniae and non-penicillinase-producing Staphylococci, which is similar to or slightly inferior to penicillin. Ampicillin also has a good antibacterial effect on viridans streptococci, and is better than penicillin on enterococci and Listeria. This product has antibacterial activity against Corynebacterium diphtheriae, Bacillus anthracis, Actinomyces, Haemophilus influenzae, Bordetella pertussis, Neisseria and anaerobic bacteria except Bacteroides fragilis. Some Proteus mirabilis, Escherichia coli, Salmonella and Shigella are sensitive to this product. Ampicillin exerts its bactericidal effect by inhibiting bacterial cell wall synthesis.

This product is a semi-synthetic penicillin antibiotic. It has antibacterial effects on Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Proteus, Enterobacter, Citrobacter, Serratia, Acinetobacter, and Gram-positive cocci sensitive to penicillin. It has a bactericidal effect in large doses. Its antibacterial activity against Escherichia coli, Enterobacter, Klebsiella pneumoniae, Citrobacter, Serratia, and Acinetobacter is stronger than carbenicillin and ampicillin; its antibacterial activity against indole-positive Proteus and Pseudomonas aeruginosa is stronger than carbenicillin and sulbenicillin; its antibacterial activity against Gram-positive bacteria such as Staphylococcus aureus is similar to that of carbenicillin, and its antibacterial activity against Streptococcus faecalis is superior to that of carbenicillin and sulbenicillin. It has good antibacterial effect against most anaerobic bacteria such as Bacteroides fragilis.

This product is a semi-synthetic penicillin antibiotic. It has antibacterial effects on Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Proteus, Enterobacter, Citrobacter, Serratia, Acinetobacter, and Gram-positive cocci sensitive to penicillin. It has a bactericidal effect in large doses. Its antibacterial activity against Escherichia coli, Enterobacter, Klebsiella pneumoniae, Citrobacter, Serratia, and Acinetobacter is stronger than carbenicillin and ampicillin; its antibacterial activity against indole-positive Proteus and Pseudomonas aeruginosa is stronger than carbenicillin and sulbenicillin; its antibacterial activity against Gram-positive bacteria such as Staphylococcus aureus is similar to that of carbenicillin, and its antibacterial activity against Streptococcus faecalis is superior to that of carbenicillin and sulbenicillin. It has good antibacterial effect against most anaerobic bacteria such as Bacteroides fragilis.

Extract from the above information