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1. Anti-tumor effect: It shows high anti-tumor activity against mouse leukemia L-1210 and has a wide anti-tumor spectrum against mouse transplanted tumors. It shows excellent effects on lymphocytic leukemia L1210, granulocytic leukemia C-1498, plasmacytoma X-5563 (ascites type), Ehrlich's ascites carcinoma, dural sarcoma MS-147, etc. It has a life-extending effect on mice with lymphocytic leukemia L1210 and methylcholanthrene-induced malignant glioma cells transplanted into the brain. 2. Mechanism of action: It mainly inhibits DNA synthesis by alkylating intracellular DNA and reducing its molecular weight.

This product has anti-tumor effects. Since it is a precursor of purine biosynthesis, it can interfere with purine biosynthesis. After entering the body, it demethylates to form monomethyl compounds in liver microsomes, which have direct cytotoxic effects. It mainly acts on the G2 phase. It inhibits the synthesis of purine, RNA and protein, and also affects the synthesis of DNA. Therefore, it is also considered to be an alkylating anti-tumor drug.

This product has anti-tumor effects. Since it is a precursor of purine biosynthesis, it can interfere with purine biosynthesis. After entering the body, it demethylates to form monomethyl compounds in liver microsomes, which have direct cytotoxic effects. It mainly acts on the G2 phase. It inhibits the synthesis of purine, RNA and protein, and also affects the synthesis of DNA. Therefore, it is also considered to be an alkylating anti-tumor drug.

Vincristine is an active ingredient extracted from the Apocynaceae plant Catharanthus roseus. The anti-tumor target is microtubules, mainly inhibiting the polymerization of tubulin and affecting the formation of spindle microtubules. It stops mitosis at metaphase. It can also interfere with protein metabolism and inhibit the activity of RNA polymerase, and inhibit the synthesis of cell membrane lipids and the transport of amino acids on the cell membrane. Vincristine has a greater inhibitory effect on transplanted tumors than vinblastine and has a wider anti-tumor spectrum. In addition to being effective against tumor strains sensitive to vinblastine, it also has effects on mouse Ridgeway osteosarcoma, Mecca lymphosarcoma, X-5563 myeloma, etc. There is no cross-resistance between vincristine, vinblastine and vindesine, and vincristine has the strongest neurotoxicity among the three.