Berberine Trimethoprim Tablets

Berberine hydrochloride and trimethoprim have synergistic antibacterial effects. Berberine hydrochloride has inhibitory effects on a variety of Gram-positive and Gram-negative bacteria in vitro, among which hemolytic streptococci, Staphylococcus aureus, Vibrio cholerae, Neisseria meningitidis, Shigella, Salmonella typhi, Corynebacterium diphtheriae, etc. have stronger inhibitory effects. It also has a certain inhibitory effect on amoeba. Trimethoprim mainly interferes with bacterial folate metabolism, selectively inhibits dihydrofolate reductase, and prevents nucleic acid synthesis. Therefore, the antibacterial effect of the two combined is stronger than that of a single drug, and the number of drug-resistant strains is reduced.

This product is a compound preparation, and its components are: each tablet contains 100 mg of berberine hydrochloride and 50 mg of trimethoprim.

Used for intestinal infections such as gastroenteritis and bacillary dysentery caused by sensitive bacteria.

Oral administration: 1 to 3 capsules at a time, 3 times a day.

Nausea, vomiting, drug rash, and diarrhea will disappear after stopping the drug; itching and rash may occur, and occasionally severe exudative erythema multiforme may occur; aseptic meningitis may occasionally occur, with headaches, stiff neck, etc.

1. It is contraindicated for those who are allergic to berberine hydrochloride, trimethoprim and sulfonamide drugs. 2. It is contraindicated for children with glucose-6-phosphate dehydrogenase deficiency. 3. It is contraindicated for newborns and infants under 2 months old.

Precautions for children: 1. Berberine can cause hemolytic anemia, so it is contraindicated for children with glucose-6-phosphate dehydrogenase deficiency. 2. The trimethoprim in this product may interfere with the folic acid metabolism of breastfeeding infants. Newborns and infants under 2 years old should not use this drug; children are in the growth and development period, and their liver and kidney functions are not yet perfect, so the dosage should be reduced as appropriate. Precautions for pregnancy and lactation: 1. Since trimethoprim can cross the placental barrier, the blood concentration in the fetal circulation and amniotic fluid is close to the maternal blood concentration. Therefore, the pros and cons of this product should be weighed during pregnancy to decide whether to use it. 2. Since trimethoprim can be secreted into breast milk, its blood concentration is high, which may interfere with the folic acid metabolism of breastfeeding infants, although the problem has not been confirmed in humans. However, the use of this product for breastfeeding mothers must be decided after weighing the pros and cons. Precautions for the elderly: Elderly patients have reduced resistance and weakened metabolic capacity. When taking this product, they should pay attention to blood tests. If serious adverse reactions occur, they should stop taking the drug.

1. The interaction between berberine hydrochloride and other drugs is still unclear. 2. Trimethoprim: (1) When used simultaneously with bone marrow suppressants, the chance of leukopenia and thrombocytopenia increases. (2) When used simultaneously with dapsone, the blood concentrations of both drugs increase. The increase in blood concentration of dapsone increases and aggravates adverse reactions, especially the occurrence of methemoglobinemia. (3) When anti-tumor drugs and 2,4-diaminopyrimidine drugs are used simultaneously, it is also not advisable to use this product between courses of treatment with other folic acid antagonists, because it may cause bone marrow aplasia or megaloblastic anemia. (4) When used simultaneously with reserpine, trimethoprim elimination may be increased and plasma half-life shortened. (5) When used simultaneously with cyclosporine, nephrotoxicity may be increased. (6) It interferes with the hepatic metabolism of phenytoin, increases the half-life of phenytoin, and reduces its clearance rate. (7) When used simultaneously with procainamide, renal clearance may be reduced and the blood concentration of procainamide metabolites may be increased. (8) It inhibits the metabolism of warfarin. And enhance its anticoagulant effect.

Keep in a light-proof and airtight place.

Compound

24 months

Shanxi Weinan Huaren Pharmaceutical Co., Ltd.

• Founded in:

  1998-06-30

• Address:

  No. 13, Weihua Road, Linwei District, Weinan City, Shaanxi Province

• Tax NO.:

  91610502295258593K

• Registered Funds:

  80 million yuan

• Email:

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