Erythromycin Ethylsuccinate Granules

This product belongs to the macrolide antibiotics, which is the ethyl succinate of erythromycin. It is more stable than erythromycin in gastric acid. It has antibacterial activity against Staphylococcus (except methicillin-resistant strains), various groups of streptococci and Gram-positive bacilli. Neisseria, Haemophilus influenzae, Bordetella pertussis, etc. are also sensitive to this product. This product also has antibacterial effects on various anaerobic bacteria except Bacteroides fragilis and Fusobacterium. It also has inhibitory effects on Legionella, Campylobacter fetus, some spirochetes, Mycoplasma pneumoniae, Rickettsia and Chlamydia. This product is an antibacterial agent, but it also has a bactericidal effect on some bacteria at high concentrations. This product can penetrate the bacterial cell membrane and form a reversible bond with the 50S subunit of the bacterial ribosome near the donor site (P site), blocking the transfer RNA (t-RNA) from binding to the P site, and also blocking the displacement of the polypeptide chain from the acceptor site (A site) to the P site, thereby inhibiting bacterial protein synthesis.

Erythromycin ethylsuccinate.

This product is a suspension granule; it tastes sweet and aromatic.

1. This product is used as an alternative medicine for the treatment of the following infections in patients allergic to penicillin: acute tonsillitis, acute pharyngitis, sinusitis caused by hemolytic streptococci, pneumococcus, etc.; scarlet fever and cellulitis caused by hemolytic streptococci; diphtheria and diphtheria carriers; gas gangrene, anthrax, tetanus; actinomycosis; syphilis; listeriosis, etc. 2. Legionnaires' disease. 3. Mycoplasma pneumonia. 4. Chlamydia pneumoniae pneumonia. 5. Urinary and reproductive system infections caused by Chlamydia and Mycoplasma. 6. Chlamydia trachomatis conjunctivitis. 7. Oral infections caused by anaerobic bacteria. 8. Campylobacter jejuni enteritis. 9. Whooping cough. 10. For the prevention of recurrent rheumatic fever, infective endocarditis (after rheumatic heart disease, congenital heart disease, heart valve replacement surgery) and oral and upper respiratory tract medical operations.

Oral administration: 1.6g per day for adults, divided into 2 to 4 times. For patients with Legionnaires' disease, 0.4 to 1.0g per time, 4 times a day. The daily dose for adults should generally not exceed 4g. To prevent streptococcal infection, 400mg per time, twice a day. For chlamydia or ureaplasma urealyticum infection, 800mg per time, once every 8 hours, for 7 days; or 400mg per time, once every 6 hours, for 14 days. For children, 7.5 to 12.5mg/kg per time, 4 times a day; or 15 to 25mg/kg per time, 2 times a day; for severe infection, the daily dose can be doubled and taken in 4 times. For children with pertussis, 10 to 12.5mg/kg per time, 4 times a day, for a course of 14 days.

1. Patients with hepatotoxic reactions after taking this product are more common than those taking other erythromycin preparations. After taking the drug for several days or 1 to 2 weeks, patients may experience fatigue, nausea, vomiting, abdominal pain, rash, fever, etc. Jaundice may sometimes occur, and liver function tests show cholestasis, which can often be recovered after stopping the drug. 2. Gastrointestinal reactions include diarrhea, nausea, vomiting, upper abdominal pain, pain in the mouth and tongue, and decreased appetite, and their incidence is related to the size of the dose. 3. When a large dose of 4g/day is used, especially in patients with liver and kidney diseases or elderly patients, hearing loss may occur, which is mainly related to the high blood drug concentration (12mg/L), and most of them can be recovered after stopping the drug. 4. Allergic reactions are manifested as drug fever, rash, eosinophilia, etc., with an incidence of about 0.5% to 1%. 5. Occasionally, there are arrhythmias and oral or vaginal candidal infections.

It is contraindicated for patients who are allergic to this product or other erythromycin preparations, patients with chronic liver disease, patients with liver damage and pregnant women.

Precautions for children: Precautions for pregnancy and lactation: Prevented for pregnant women Precautions for the elderly:

1. This product can inhibit the metabolism of anti-epileptic drugs such as carbamazepine and valproic acid, resulting in increased blood concentrations and toxic reactions. Combination with alfentanil can inhibit the metabolism of the latter and prolong its duration of action. Combination with antihistamines such as astemizole or terfenadine can increase cardiac toxicity, and combination with cyclosporine can increase the latter's blood concentration and produce nephrotoxicity. 2. This product has an antagonistic effect with chloramphenicol and lincosamides, and it is not recommended to use them at the same time. 3. This product is an antibacterial agent and can interfere with the bactericidal efficacy of penicillin. Therefore, when rapid bactericidal effects are required, such as the treatment of meningitis, the two should not be used at the same time. 4. Patients who take warfarin for a long time may prolong the prothrombin time when using this product, thereby increasing the risk of bleeding. Elderly patients should pay special attention. When the two must be used at the same time, the dose of warfarin should be appropriately adjusted and the prothrombin time should be closely observed. 5. Except for dihydroxypropylphylline, the simultaneous use of this product with xanthine drugs can reduce the hepatic clearance of aminophylline, leading to increased serum aminophylline concentrations and (or) increased toxic reactions. This phenomenon is more likely to occur after 6 days of combined use, and the reduction in aminophylline clearance is proportional to the serum peak value of this product. Therefore, the dose of xanthine drugs should be adjusted during and after the combination of the two. 6. Combination with other hepatotoxic drugs may enhance hepatotoxicity. 7. The combination of large doses of this product with ototoxic drugs, especially in patients with renal impairment, may increase ototoxicity. 8. When used in combination with lovastatin, its metabolism can be inhibited and the blood concentration can be increased, which may cause rhabdomyolysis; when used in combination with midazolam or triazolam, the clearance of both can be reduced and their effects can be enhanced.

Keep away from light, sealed and stored in a dry place.

0.1 g

24 months.

Anhui ANKE HENGYI Pharmaceutical Co., Ltd.

• Founded in:

  1991-02-11

• Address:

  New Town, Economic Development Zone, Tongling City, Anhui Province

• Tax NO.:

  9134070015110558XD

• Registered Funds:

  38 million yuan

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