Recombinant human granulocyte-stimulating factor injection

Pharmacology: This product is human granulocyte colony-stimulating factor (rhGCSF) produced by genetic recombination technology. Compared with natural products, the biological activity is basically the same in vivo and in vitro. rhGCSF is one of the main cytokines that regulate granulocyte hematopoiesis in the bone marrow. It selectively acts on granulocyte hematopoietic progenitor cells, promotes their proliferation and differentiation, and can increase the function of terminally differentiated granulocyte cells. Toxicology: Acute toxicity: A single injection of 5040 mu;g/kg of this product into the tail vein of mice is equivalent to 1000 times the general clinical injection dose. No poisoning reactions were observed after 10 consecutive days of observation. Subacute toxicity: The mice were given the drug for 4 weeks (intravenous and subcutaneous injections) and the no-effect dose for 13 weeks (intravenous injections) was 1mu;g/kg/day. Giving 1

Main ingredients: recombinant human granulocyte colony stimulating factor

This product is a colorless transparent liquid.

1. Neutropenia caused by cancer chemotherapy and other reasons; cancer patients use bone marrow suppressive chemotherapy drugs, especially after strong bone marrow deprivation chemotherapy drugs, injection of this product can help prevent the occurrence of neutropenia, reduce the degree of neutropenia, shorten the duration of agranulocytosis, accelerate the recovery of granulocyte count, and thus reduce the risk of concurrent infection and fever. 2. Promote the increase of neutrophil count after bone marrow transplantation. 3. Neutropenia caused by myelodysplastic syndrome, neutropenia caused by aplastic anemia, congenital and idiopathic neutropenia, myelodysplastic syndrome with neutropenia, and cyclical neutropenia.

1. For tumors, it is used for neutropenia caused by chemotherapy, etc. For adult patients whose neutrophil count drops below 1000/mm3 (white blood cell count 2000/mm3) after chemotherapy, 2-5g/kg should be administered subcutaneously or intravenously once a day after starting chemotherapy. For children whose neutrophil count drops below 500/mm3 (white blood cell count 1000/mm3) after chemotherapy, 2-5g/kg should be administered subcutaneously or intravenously once a day after starting chemotherapy. When the neutrophil count rises back to above 5000/mm3 (white blood cell count 10000/mm3), stop administering the drug. 2. Neutropenia caused by chemotherapy for acute leukemia Leukemia patients after chemotherapy

1 Musculoskeletal system: sometimes there will be muscle soreness, bone pain, back pain, chest pain. 2 Digestive system: sometimes there will be loss of appetite, or liver alanine aminotransferase and aspartate aminotransferase will increase. 3 Others: some people will have fever, headache, fatigue and rash, ALP and LDH will increase. 4 Very few people will experience shock, interstitial pneumonia, adult respiratory distress syndrome, and increase in immature cells.

1. Patients who are allergic to granulocyte colony stimulating factor and other preparations expressed by Escherichia coli are contraindicated. 2. Patients with severe liver, kidney, heart, and lung dysfunction are contraindicated. 3. Myeloid leukemia patients whose immature granulocytes in the bone marrow have not been significantly reduced or myeloid leukemia patients with immature granulocytes detected in peripheral blood.

Precautions for children: Use with caution in children and give appropriate monitoring; since the safety of the drug for newborns and infants has not been determined, it is recommended not to use the drug. No long-term toxic effects were found in patients aged 4 months to 17 years who took the drug daily, and their growth, development, sexual characteristics and endocrine system were not changed. Precautions for pregnancy and lactation: Safety during pregnancy has not been established. When it is proven that the potential benefits of the drug for pregnant women outweigh the potential risks to the fetus, it should be used. Lactating women should stop breastfeeding before taking the drug. Precautions for the elderly: The physiological function of elderly patients is relatively low, so it is necessary to observe the patient's condition, pay attention to the dosage and interval, and administer the drug with caution. Its safety and effectiveness have not yet been established.

It is not completely clear. Drugs that promote the release of white blood cells (such as lithium) should be used with caution.

Store at 2～8℃ away from light +2 years

250μg/vial

24 months

CSPC Baike (Shandong) Bio-Pharmaceutical Co., Ltd.

• Founded in:

  1994-01-21

• Address:

  No. 212, Jinbu Street, Qinshui Korean Industrial Park, Muping District, Yantai City, Shandong Province

• Tax NO.:

  91370612613203660U

• Registered Funds:

  734.7 million yuan

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