Calcium folinate for injection
Ingredients
The main ingredient and its chemical name are: Calcium folinate. The chemical name is: 5-methyl-5,6,7,8-tetrahydropteroyl-L-monoglutamic acid calcium salt. Its structural formula is: Molecular formula: C20H21CaN7O7bull;5H2O Molecular weight: 601.61.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| Calcium folinatcIngredients |
5-Methyl-5,6,7,8-tetrahydropteroyl-L-monoglutamic acid calcium salt More |
6035-45-6 | 6 |
Indication
It is mainly used as an antidote for folic acid antagonists (such as methotrexate, pyrimethamine or trimethoprim). This product is often used clinically to prevent severe toxic effects caused by overdose or high-dose treatment of methotrexate. When oral folic acid is ineffective, it is also used for megaloblastic anemia caused by stomatitis, diarrhea, malnutrition, pregnancy or infancy, but it is not suitable for vitamin B12 deficiency anemia. In recent years, calcium folinate has been used as an adjuvant treatment for colon and rectal cancer, and combined with fluorouracil, it can prolong survival.
Usage and Dosage
The prescribed dosage and administration time should be strictly followed and should not be changed at will. Additional dosage or discontinuation of medication must be agreed upon by the responsible physician. For intramuscular injection as a "rescue" therapy for methotrexate, the dosage of this product is best determined based on blood drug concentration. The general dosage is 9-15 mg/m2 based on body surface area, once every 6-8 hours for 2 days until the serum concentration of methotrexate is below 5×10-8 mol/L. As an antidote for pyrimethamine or trimethoprim, each dose is 9-15 mg intramuscularly, depending on the poisoning situation. For anemia, 1 mg is injected intramuscularly daily. Intravenous injection as an adjuvant treatment for colorectal cancer, combined with fluorouracil
Adverse Reactions
Rarely, skin rash may occur. Look for allergic reactions such as hives or asthma.
Precautions
It is contraindicated in pernicious anemia and megaloblastic anemia caused by vitamin B12 deficiency.
Drug Interactions
The use of this product in large doses together with barbiturates, primidone or phenytoin sodium may affect the anti-epileptic effect.
Storage
Store in a sealed container away from light.
Packaging Specification
100mg