Ondansetron Hydrochloride Injection

Pharmacological action: This product is a selective 5-hydroxytryptamine 3 (5-HT3) receptor antagonist. Its mechanism of action is not yet fully understood. It may be through antagonizing the 5-HT3 receptors in the peripheral vagus nerve endings and central chemoreceptor areas, thereby blocking the vomiting reflex caused by factors such as chemotherapy and surgery that promote the release of 5-hydroxytryptamine from intestinal chromaffin cells and excite the vagus afferent nerves. This product has high selectivity and no side effects such as extrapyramidal reactions and excessive sedation. Toxicological studies Reproductive toxicity: When this product is administered orally at a dose of 15 mg/kg/day, it has no significant effect on the fertility and general reproductive behavior of male and female rats. The results of animal experiments did not show teratogenic effects. When this product was administered intravenously at a dose of 4 mg/kg/day in pregnant rats and rabbits, no effects were shown.

Ondansetron Hydrochloride

This product is a colorless clear liquid.

Antiemetic. Indicated for: 1. Nausea and vomiting caused by cytotoxic chemotherapy and radiotherapy. 2. Prevention and treatment of postoperative nausea and vomiting.

This product can be administered by intravenous drip and intramuscular injection. The dosage and route of administration depend on the severity of vomiting. The adult dose is generally 8 mg per day. 1 For vomiting caused by highly emetic chemotherapy drugs: intravenously drip 8 mg of this product 30 minutes before chemotherapy, 4 hours after chemotherapy, and 8 hours after chemotherapy, and take 8 mg tablets orally every 8-12 hours after stopping chemotherapy. 2 For vomiting caused by chemotherapy drugs that are not too emetic, intravenously drip 8 mg of this product 30 minutes before chemotherapy, and then take 8 mg tablets orally every 8-12 hours for 5 consecutive days. 3 For vomiting caused by radiotherapy, the first dose should be taken as an 8 mg tablet 1-2 hours before radiotherapy, and then 8 mg every 8 hours. 4

There may be headache, warm feeling in the head and upper abdomen, abdominal discomfort, constipation, dry mouth, rash, local reaction at the injection site, occasional bronchial asthma or allergic reaction, temporary asymptomatic transaminase elevation, the above reactions are generally mild and do not require special treatment. There are rare reports of movement disorders, epileptic seizures, chest pain, arrhythmia, hypotension and bradycardia.

It is contraindicated for those who have allergic reactions to this product or those with gastrointestinal obstruction.

1 Clinical application In the prevention and treatment of acute vomiting, the combination of ondansetron and dexamethasone is significantly more effective than ondansetron alone. 2 It is reported that the antihypertensive effect of calcium antagonists is also enhanced when used in combination with isohydroxydigitonin or cimetidine. The antihypertensive effect of this drug may also be enhanced when used in combination with other antihypertensive drugs, so care should be taken when using it. 3 This product cannot be mixed with other drugs in the same syringe or injected at the same time.

Keep in a dark and airtight place in a cool place. Valid for 24 months.

2ml:4mg (calculated as C18H19N3O)

Shandong Beida Gaoke Huatai Pharmaceutical Co., Ltd.

• Founded in:

  1992-07-23

• Address:

  No. 1 Haishi Road, Penglai City, Shandong Province

• Tax NO.:

  9137068461341859XD

• Registered Funds:

  80 million yuan

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